Talk:Phosphodiesterase

Redirect to Phosphodiester bonds ?
Iiuc, phosphodiesterase normally refers specifically to enzymes that degrade cyclic AMP, and has nothing to do with the bonds between adjacent nucleotides that are the main focus of the redirect article. If it's going to redirect somewhere, it should be to cyclic AMP. But I'm not going to start a redirect war. -- dsws 03:49, 12 July 2005 (UTC)


 * Yes, I totally agree with dsws. Phosphodiesterase (PDE) represents a large group of enzymes that degrade the cyclic nucleotides, cyclic AMP and cyclic GMP. PDE can be further grouped into 11 families and I think PDE deserves a page by itself and the re-direction is inappropriate. --Wkong 01:08, 10 December 2005 (UTC)


 * I concur. IMO, the redirect to Phosphodiester bonds was inappropriate. I've rewritten the article to a small stub. -- PFHLai 07:22, 10 December 2005 (UTC)

If you say that there are 11 families of PDEs it would be good to mention that this is only true for mammalian cells.

more generally...
Technically a phosphodiesterase is any enzyme that breaks a phosphodiester bond. This includes DNAses (including restriction enzymes)and RNAses, clycic nucleotide phosphidesterases, and phospholipases C & D. Cyclic nucleotide PDEs may be the family that comes to most peoples' minds when they think of phosphodiesterases but I think the current description is too narrow. I'm happy to expand the page a bit if there's support for this idea... Roadnottaken 16:15, 21 March 2007 (UTC)
 * I agree, and MeSH agrees. Your expansion of the article would be quite welcome. --Arcadian 17:09, 21 March 2007 (UTC)
 * I'm a little confused about how to proceed. This article is quite good, only, it refers to cyclic nucleotide phosphodiesterases, rather than phosphodiesterases in general.  I'd like to just change the title of this page (and fix pages that link to it) and make a new page that points to all the different types of phosphodiesterases... advice?  Roadnottaken 19:44, 30 March 2007 (UTC)

Insulin sensitive PDE?
I think it would be good to add a section regarding its role in endocrine controlled metabolism, namely insulin-sensitive PDE which decreases levels of cAMP. — Preceding unsigned comment added by Thetokster (talk • contribs) 09:54, 25 May 2011 (UTC)

Clinical and molecular genetics
10.1210/er.2013-1053 Endocr Rev JFW &#124; T@lk  19:47, 31 March 2014 (UTC)