Talk:Plasma cell

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I deleted the following text from the text since it is incorrect. B-cells are indeed professional Antigen-presenting cells and therefore need to have MHCII. See the article on B-cells. If the user who wrote this has a better source, please let us know.../Eribro 21:35, 13 November 2006 (UTC)
 * WARNING!The content on this page is INCORRECT! Consult a different source. B-cells DO NOT HAVE MHCIIs=--macrophages do. B-cells ARE NOT phagocytic.


 * The source which you cite is ALSO incorrect. As I stated in the discussion for the B-cells article:
 * The second paragraph regarding the 2nd paragraph in "The Ancestry of B-cells" should be deleted, or a second reference should be cited.
 * The Nature Immunology 2006 paper referenced (Li et al) DOES NOT state that mammalian B-cells are capable of/activated following antigen phagocytosis. Trout and frogs are not mammals. MALIGNANT (not normal) mammalian B-lymphocytes acquire phagocytic capability, implying a common ancestry for APCs and B lymphocytes in mammals.
 * 130.219.4.164 (talk) 23:45, 30 January 2008 (UTC)Anonymous Med Student

I was under the impression that B-Cells became plasma and memory cells at the germinal center. This article states the B-Cells become the germinal center. This article contradicts the article on germinals centers; however, I don't know if B-Cells become three different cells or if the number mentioned erroniously counted the germinal center.

-Franco Healy —Preceding unsigned comment added by Fdhealy (talk • contribs) 22:13, 7 October 2009 (UTC)

Half the story
We seem to have an ongoing problem with this article. Plasma cells (in humans) generally (not always) arise in the spleen. What is the precursor cell? An undifferentiated B cell. Where did that B cell come from? The bone marrow.

So do plasma cells come from the spleen or the bone marrow? The answer is "both" -- or just the bone marrow, if you're talking about a person with no spleen. I'll see whether I can find some decent sources and explain this so that neither group of thoughtless or ill-informed editors will continue asserting that their favorite half of the story is the whole story. WhatamIdoing (talk) 01:05, 12 June 2009 (UTC)

The picture of malignant PC's
Can anyone explain what I see in the picture with the caption: "Malignant plasma cells (plasmacytoma), with the characteristic "clockface nuclei" seen in normal plasma cells." Which ones are the normal cells (if any) and which the malignant ones? — Preceding unsigned comment added by Aoosten (talk • contribs) 00:42, 19 December 2010 (UTC) clockface nuclei ones are normal.-med school histo class. —Preceding unsigned comment added by 98.163.227.209 (talk) 01:05, 25 February 2011 (UTC)

contradctn
2factrsafeguard?Differentiation through a T cell-independent antigen stimulation (stimulation of a B cell that does not require the involvement of a T cell) can happen anywhere in the body[2] and results in short-lived cells that secrete IgM antibodies81.11.207.191 (talk) 17:09, 22 November 2016 (UTC)