Talk:Platensimycin

Needs re-writing
This article desperately needs to be re-written. I'm not completely familiar with how people write on wikipedia, but the segments here seem to be copied and pasted from another source. The references seem to be two-fold; a direct wikipedia reference and another one in square brackets. The entire page reads like a Merck advertisement for their research abilities.

"Platensimycin, a metabolite of Streptomyces platensis, which is an excellent example of a unique structural class of natural antibiotics, has been demonstrated to be a breakthrough in recent antibiotic researches due to its unique functional pattern and significant antibacterial activity"

Excellent? Significant? Unique twice? What's the difference between functional pattern and antibacterial activity? Antibacterial AND antibiotic in the same sentence?

All the research is essentially by Merck. Sheo Singh works for the company.

Half of what is written is unneeded. AntibioticNihilist (talk) 00:01, 9 July 2012 (UTC)

Could
Could someone who has a subscription to Nature access this article on platensimycin http://www.nature.com/news/2006/060515/full/441260a.html ? It looks like it might provide some perspective but I can't get into it. Thanks! 207.107.246.20 13:59, 19 May 2006 (UTC)

The nature news article was mostly a summary of other findings that have been posted in Nature or in other research articles, so there is nothing new to add from it. Darrylthered (talk) 18:58, 28 November 2007 (UTC)

Platensimycin and other antibiotics targeting the FAS enzymes seem of limited interest in therapeutic. Indeed many important pathogens (Staphylococcus, Streptococcus, Enterococcus) are likely to use the lipids present in the host serum to thrive in the patient. This was clearly evidenced when FAS mutants of these pathogens were shown to grow on medium supplemented with human serum and to colonize mice with the same efficiency as the wild type strains; indeed no antibiotic could have a stronger inhibitory effect on an enzyme than the deletion of the encoding gene. Cf/Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens. Brinster et al.Nature 2009, 485:85-86 (Sporologue (talk) 14:26, 12 March 2009 (UTC))

WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 09:41, 10 November 2007 (UTC)