Talk:Pramlintide

aids in the absorption of glucose ?
I just had a question about "pramlintide aids in the absorption of glucose" which does not seem quite correct as ultimately it reduces post-prandial glucose. Heli dr (talk) 18:16, 5 January 2011 (UTC)


 * I share your concerns: as you said it's a PPHG reducers. I mean, it depends on how you interpret the "aids": in a certain way it aids in the absorption of glucose, not because it increases the amount of glucose absorbed but because it produces a smoother curve in the glycaemia (as opposed to a sharper peak) by decreasing the gastric emptying rate (and inhibiting the glucagon secretion by alpha cells). What I would like to point out is that, in the same sentence, it sounds weird to my non-english ears to read "By augmenting endogenous amylin". While pramlintide is, yes, an amylin analogue it has with a different amminoacidic sequence and different properties (above other it has a longer half-life and doesn't give aggregation like amylin) than amylin. In other words to my eyes it can't be just considered to be like the endogenous amylin tout court. I see here the same difference between the first human recombinant insulin and the rapid-acting insulin analogues LisPro Asparte etc, just to remain in topic. -- Radio89 (talk) 18:35, 19 February 2012 (UTC)


 * Maybe my edits help a little bit? AvB (talk) 01:52, 8 August 2017 (UTC)

Other effects
"Symlin also prompts a marker for Alzheimer’s – amyloid beta – to travel from the brain to the blood." - Rod57 (talk) 17:12, 21 March 2017 (UTC)