Talk:Prednisolone

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Szetoc 16, Rduong16, Pharming16. Peer reviewers: Hp15elephants, Gyang15, Chiucc15.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 07:07, 17 January 2022 (UTC)

Side effects
Most recent edit added side effects taken from the medication factsheet that came with the prednisolone I've just been prescribed. 212.139.98.72 20:04, 2 September 2007 (UTC)

Banned substance
Can anyone shed some light on why prednisolone is a banned substance for athletes? Anabolic steroids I obviously understand, but how would prednisolone enhance performance? 24.21.221.225 (talk) 19:48, 25 January 2008 (UTC)
 * by inhibiting the inflammatory reponse in overtaxed joints and muscles. pitchers' arms, polevaulters' shoulders, everybody's knees. its like a super ice pack. why is it banned? just look at that list of adverse side effects. moreover, pain is nature's way of saying 'don't do that any more'. inhibit the pain response and you can do serious damage to musculoskelatal anatomy over time. not saying that any of them abused corticosteroids, but look at all the ex-jocks walking around on 2 artificial knees. that's what you get from 'playing with pain'.Toyokuni3 (talk) 04:20, 25 August 2008 (UTC)

Prednisolone won't be tasted
Since prednisolone is the active metabolite of prednisone and is only formed at the liver then isn't it prednisone that has the bitter taste "that makes it difficult to administer to children"? The line concerned should be removed from this article and transferred to the prednisone article. Meltyman (talk) 08:14, 17 May 2008 (UTC)

Additional ADRs of Corticosteroids
A recently obtained (7/26/2011) drug information sheet from a local branch of a nationwide pharmacy lists under cautions:

"Corticosteroid medicines may affect growth rate in children and adolescents in some instances." One presumes this is a long course.

Consultation with a doctor before being immunized while on a course of Prednisolone.

Is excreted in breast milk.

Advises physician consultation for use during pregnancy.

66.92.11.54 (talk) 02:29, 27 July 2011 (UTC)Literate Dad 67.142.181.23 (talk) 09:42, 25 October 2012 (UTC)

Contaminated Lots of Methylprednisolone Acetate
Infections under Investigation in Patients Exposed to NECC Products Other than the 3 Contaminated Lots of Methylprednisolone Acetate

Meningitis, Spinal or Paraspinal Infection A person who developed any of the following after epidural or paraspinal2 injection after May 21, 2012 of an NECC product:

Meningitis of unknown etiology. Osteomyelitis, abscess or other infection (e.g., soft tissue infection) of unknown etiology, in the spinal or paraspinal structures at or near the site of injection. Fungal Infection of Interest A person who developed fungal infection in a normally sterile site4 with laboratory evidence by culture, histopathology, molecular (e.g. NAAT or PCR), or positive galactomannan test following administration of an NECC product into a sterile site after May 21, 2012.

1.Products from NECC other than the 3 contaminated lots (05212012@68, 06292012@26, 08102012@51) of methylprednisolone acetate.

2.Paraspinal injections include, but are not limited to, spinal facet joint injection, sacroiliac joint injection,or spinal or paraspinal nerve root/ganglion block.

3.Clinically diagnosed meningitis with one or more of the following symptoms: headache, fever, stiff neck, or photophobia, in addition to a CSF profile showing pleocytosis (>5 white blood cells, adjusting for presence of red blood cells by subtracting 1 white blood cell for every 500 red blood cells present) regardless of glucose or protein levels.

4.Normally sterile sites include blood, CSF, pleural fluid, peritoneal fluid, pericardial fluid, surgical aspirate, bone, joint fluid, or internal body site (e.g., eye, lymph node or brain).

Division of Healthcare Quality Promotion (DHQP) 67.142.181.23 (talk) 08:22, 25 October 2012 (UTC)

67.142.181.23 (talk) 09:15, 25 October 2012 (UTC)

67.142.181.23 (talk) 09:34, 25 October 2012 (UTC)67.142.181.23 (talk) 09:36, 25 October 2012 (UTC)67.142.181.23 (talk) 09:42, 25 October 2012 (UTC)

Edits by Pharming 16
We edited the content explaining the mechanism of action for prednisolone. There was no reliable way of cross checking the outdated references so we used more recent data from a secondary source to explain this section. We also updated the potential side effects that may occur with Prednisolone. In addition, we found review articles to support some statements made what prednisolone may be used for. — Preceding unsigned comment added by Pharming16 (talk • contribs) 19:25, 5 November 2015 (UTC)

Peer Review from Gyang15
The article does contain a neutral view. The cited references are verifiable. Our recommendations include: Pros: Good, clear explanation of the mechanism of action for prednisolone. There are high quality references for mechanism of action. Cons: The lead should include other general information about prednisolone, such as it’s most common/major indications and common side effects. It wouldn’t hurt to put references for all of the adverse effects or to reference that a certain source covers all of the adverse effects. I can’t seem to find a source for your image in the MOA section. The paper you used for the text is great, but it’s hard to be certain the image reflects that. — Preceding unsigned comment added by Gyang15 (talk • contribs) 02:59, 9 November 2015 (UTC)

Corticosteroid in lead?
I'm not a medic or pharmacist so hesitate to change the lead sentence here myself, but could I suggest that the link to Corticosteroid shouldn't be piped? As a non-specialist, I didn't know whether "steroid medication" implied "corticosteroid" or not. Perhaps: "Prednisolone is a corticosteroid medication used ..." would be clearer? Pam D  21:53, 29 January 2018 (UTC)
 * we try to make the leads plain english and simple. my sense is that most people have heard of "steroids" but not of "corticosteroids" which are indeed a kind of steroid the pipe is there if anybody wants to dig deeper. does that make sense enough? Jytdog (talk) 22:09, 29 January 2018 (UTC)
 * As a patient, I was coming from the angle of "I know it's a steroid, but something I read was about corticosteroids: is Prednisolone one of those or not? Is "corticosteroids" just another word for "steroids"?" OK, the "steroid medication" link goes to Corticosteroids and it's also explicitly stated in the opening sentence of the first, "Medical uses", section, but I'd have preferred to have my question answered in the lead. Can't please everyone.
 * Just out of curiosity I looked up Cortisone, another drug that I'd heard of and thought was probably a steroid: its lead says it's a steroid hormone, and its "Effects and uses" section starts by describing it as a glucocorticoid, which article then clarifies that these are a class of Corticosteroids. So we get the info eventually but by a different collection of links. What's that phrase about consistency being for small minded people (thus not for Wikiipedia editors!) ... found it: "A foolish consistency is the hobgoblin of little minds". 'nuff said. Thanks. Pam  D  23:13, 29 January 2018 (UTC)

Wrong source for history of Prednisolone
"Prednisolone was discovered and approved for medical use in 1955.[7]" - But [7] (Kim K, Roh JK, Wee H, Kim C (2016). Cancer Drug Discovery: Science and History) describes Prednisone, which is supposed to be a different drug and specifically mentioned in the "Not to be confused with" note at the beginning. — Preceding unsigned comment added by Avatar(DS) (talk • contribs) 06:49, 7 April 2020 (UTC)

COVID-19
I have included the following warning from my GP as a matter of urgency. (It is often prescribed as an emergency pack which can be taken when needed without having to wait for a clinic appointment) If someone can find a published reference to quote it would be gratefully received.

Use of Prednisolone as an anti-inflammatory, for instance in COPD exacerbation, is contraindicated if the person is infected with COVID-19 or suspects they may be. — Preceding unsigned comment added by Chevin (talk • contribs)
 * A reliable source that is verifiable is needed. Schazjmd   (talk)  21:19, 1 June 2020 (UTC)

Proposed merge of Topical Prednisolone into Prednisolone
Topical prednisolone is an unnecessary fork of prednisolone. — rsjaffe 🗣️ 03:57, 25 May 2022 (UTC)


 * Support as per nominator. Bibeyjj (talk) 18:02, 9 June 2022 (UTC)
 * Support to avoid dividing relevant info on medical use in article on compound BluePenguin18 🐧  ( 💬 ) 04:04, 25 February 2023 (UTC)
 * ✅ Klbrain (talk) 14:41, 25 February 2023 (UTC)