Talk:Pregnenolone

Nooptropic studies
There are a lot of studies on the effects of pregnenolone and it is a rather common dietary supplement; I am surprised that more about this is not mentioned in this article. I will dig out my studies on pregnenolone if I find time. Agalmic (talk) 14:29, 28 June 2008 (UTC)

chemical box-thing
one of those chemical boxes with lots of info in them needed for this article. --Suleyman Habeeb 16:06, 7 August 2006 (UTC)

Coconut oil
Fact: When humans eat coconut oil, pregnenolone production rises. —Preceding unsigned comment added by 24.230.195.63 (talk) 04:16, 14 January 2009 (UTC)

Regarding this Drug
Nothing about Dosages, Indications, Contraindications, Side Effects? Nei1 (talk) 00:37, 27 December 2010 (UTC)
 * As far as I know it is not an approved drug, but an endogenous compound and used for research, not for treating medical conditions. Panoramix303 (talk) 18:22, 27 December 2010 (UTC)

It's not a drug. It is an orthomolecular hormone. Encyclopedant (talk) 23:26, 22 February 2012 (UTC)

solubility
Anyone know what a saturated solution in water and EtOH would be? --76.170.19.29 (talk) 05:54, 25 January 2012 (UTC)

Reference #5 concerning long term effects
When checking this reference, it seems the article has misstated the harmful long term effect information. The fact sheet is referring to inhaling dust material and is in a different numerical value than stated in in the article. Many people take pregnenolone suppements and to state that long term effects on the pituitary start at .5 mg does not seem to be accurate. Pease review. Thanks — Preceding unsigned comment added by 68.5.82.46 (talk) 17:25, 29 January 2012 (UTC)

History, discovery, name
I'm having a hard time finding out who discovered pregnenolone and how it got its name. The earliest paper I find is
 * Effects on industrial production of the administration of Delta5 pregnenolone to factory workers. Psychosom Med 1945 Nov;7:342-52..

but that clearly can't be the first publication on pregnenolone. Encyclopedant (talk) 23:24, 22 February 2012 (UTC)

Pregnenolone and GABA Receptors
I'd been under the impression that pregnenolone was a GABA antagonist in vitro, and it was its metabolites in vivo which were responsible for its GABA agonism. I could be misremembering this. However I checked out the source for that sentence (http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2006.00053.x/pdf) and couldn't find any support for the claim of pregnenolone's GABA agonism there. Could someone bring some sources to bear on the issue? --Ryan W (talk) 09:41, 4 January 2013 (UTC)

anti - marijuana effects
http://news.yahoo.com/scientists-discover-hormone-blocks-marijuana-buzz-111543669.html — Preceding unsigned comment added by 76.176.108.8 (talk) 05:08, 7 January 2014 (UTC) pregnenolone, a molecule produced by the brain, acts as a natural defence mechanism against the harmful effects of cannabis/marijuana in animals. Pregnenolone prevents THC/Tetrahydrocannabinol, the main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that when overstimulated by THC/Tetrahydrocannabinol causes the intoxicating effects of cannabis/marijuana. 2 major behavioural problems are associated with regular cannabis use in humans: cognitive deficits and a general loss of motivation(http://www.eurekalert.org/pub_releases/2014-01/ind-mdt010214.php, http://en.wikipedia.org/wiki/Pregnenolone , http://en.wikipedia.org/wiki/Tetrahydrocannabinol and http://en.wikipedia.org/wiki/Cannabis)