Talk:Procarbazine

Huh?
"It is also highly carcinogenic - patients have a 5-10% risk of developing acute leukemia,"

What? Either this statement is extremely lacking in context, or there is no way this drug could ever be used on humans. If the later is true, the entire article needs a re-write because it's written in the current tense.

Maury (talk) 18:23, 3 June 2008 (UTC)
 * It does seem dubious, and it is an unreferenced statement, so I have removed it. -- Ed (Edgar181) 19:39, 24 August 2010 (UTC)

Procarbazine is considered to be "possibly carcinogenic". The phrasing of the initial poster was very poorly worded, but I do believe it should be added back. Many anti-cancer drugs carry risk (or possibly significant risk) of secondary malignancies. From the sources I use regularly, Procarbazine is listed as carrying risk for AML (acute myeloid leukemia) and Lung Cancers. Aside from the source I cited (UpToDate.com) this is also present in a few of my pharmacology books (Brenner/Katzung) and in the Board Review book First Aid. I don't have all these books info in front of me to cite at the moment. Paul K. &#124; MechE &#124; MSY-2 &#124; Chemist &#124; Let's talk 15:10, 7 November 2019 (UTC)

Cost
Does it really cost $50 per capsule in the US? It's £3.80 trade in the UK, which is about $5, not $50. --81.154.227.79 (talk) 18:04, 24 August 2010 (UTC)
 * Drug pricing can be highly variable, so I have removed the statement. It's not all that relevant to an encyclopedia article anyway.  -- Ed (Edgar181) 19:39, 24 August 2010 (UTC)

"depression"
doc james I know the WHO ref says "depression" but i think they meant "lethargy". have not found any other ref that says that. Jytdog (talk) 00:26, 20 December 2016 (UTC)
 * Hey User:Jytdog here it also says "possible mental depression"  Doc James  (talk · contribs · email) 03:16, 21 December 2016 (UTC)
 * right which isn't depression (mood) or major depressive disorder which is what plain old "depression" will lead folks to think... what the heck is "mental depression"?  Jytdog (talk) 03:25, 21 December 2016 (UTC)
 * That is depression (mood) or major depressive disorder. They state "mental depression" to separate it from having depressed strength or energy. Doc James  (talk · contribs · email) 04:47, 21 December 2016 (UTC)

Veterinary use
Procarbazine is also used as chemotherapy for some animals. The article only speaks of humans. Worth an addition? Syneil (talk) 09:15, 16 February 2017 (UTC)

MOA: Procarbazine
The MOA for Procarbazine is still poorly understood; but there does seem to be a better understanding now associated with methylation etc. I don't want to make an official edit of the article page; only because I don't have the PubMed article I read on this readily available. But I am on the UpToDate article and it also confirms the same idea: "Procarbazine inhibits DNA, RNA, and protein synthesis by inhibiting transmethylation of methionine into transfer RNA; may also damage DNA directly through alkylation." The Link is here for anyone with access to read: UpToDate. Paul K. &#124; MechE &#124; MSY-2 &#124; Chemist &#124; Let's talk 15:22, 7 November 2019 (UTC)