Talk:Progenitor cell

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 13 January 2020 and 6 May 2020. Further details are available on the course page. Student editor(s): Cfennell2016.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 07:16, 17 January 2022 (UTC)

Untitled
I find progenitor cells difficult to put a precise definition on. The way I like to use the term is for any immature cell with a propensity to differentiate towards a particular lineage and/or a limited capacity for self renewal. This will encompass both multipotent cells, and cells which are quite limited in potential. For example, muscle satellite cells are a good example of what I consider as progenitor cells with limited differentiated capacity.

A true stem cell should be pluripotent, however some "stem cells" such as haematopoietic stem cells are only multipotent. Other cell types such as bone marrow stem cells are believed to be pluripotent, but in vivo are likely to only contribute to a few cell types (such has osteoblasts, and perhaps pericytes etc). Thus I would still classify these cell types as progenitor cells.

Thus I prefer using progenitor cells to describe a wide range of cell types, leaving the stem cell term to be limited to what they were originally meant to describe - truly totipotent/pluripotent cells with unlimited capacity for self renewal.

Of course, this is only the way I like to use the term, but I'd be interested to see what other cell biologists think.

Dr Aaron 11:36, 3 October 2006 (UTC)

I've expanded the page, but I realise it could use some references. I'll try to find some in the next few weeks, when I get a chance.

Dr Aaron 00:41, 14 October 2006 (UTC)

The initial introduction paragraph is slightly confusing and could possibly benefit from re-working the wording of the paragraph. Cfennell2016 (talk) 00:25, 3 February 2020 (UTC)

The section titled "Development of the human cerebral cortices" seems a little short to be its own section. Development of this section or a way to work it into the main article would be beneficial. Cfennell2016 (talk) 00:34, 3 February 2020 (UTC)

Table of cell types and defining CDs
the examples section list some but can we have here (or link to) a table of progenitor cell types and their CDs ? Cluster of differentiation has a table but it has only one line for stem cells and doesn't identify any as progenitor cells. - Rod57 (talk) 03:05, 18 December 2012 (UTC)

Multipotent progenitor
Multipotent progenitor is piped here from CD135 but is not described in the article (although one source talks of multipotent pancreatic progenitors). Lymphopoiesis says "The acquisition of CD27 and Flt3 by the HSC coincides with the loss of long-term repopulating potential. At this stage the cells retain both lymphoid and myeloid potential and are referred to as multipotent progenitors. (Medical Immunology, p. 114)" - Rod57 (talk) 03:50, 18 December 2012 (UTC)

Assessment comment
Substituted at 03:26, 30 April 2016 (UTC)

Are satellite cells progenitor cells?
In the examples section, satellite cells top the list. Yet the last sentences of the second paragraph of the entry on satellite cells reads: "Satellite cells are able to differentiate and fuse to augment existing muscle fibers and to form new fibers. These cells represent the oldest known adult stem cell niche, and are involved in the normal growth of muscle, as well as regeneration following injury or disease." So satellite cells may not be progenitor cells. Anyone disagree who can give citations to support their views? --Ben Best:Talk 14:42, 19 July 2016 (UTC)