Talk:Promethazine

Chemical Properties
noticed there wasn't a major section on its pharmacology and kinetics, only a brief few sentences in the introductory paragraph regarding its chemistry. Since I saw the chemical structure graphic on the right side of the page showed its enantiomers, I felt it was necessary to mention it was a chiral compound that occured as a mixture of the (R) and (S) and added a sentence about it. That shouldn't require a source, but if one is needed, I can find one - I assumed it's common knowledge among chemists. Would it be a bad idea to create a whole new section devoted to its chemical properties? Including mechanism of action in more detail? Or is the article fine as is? Thanks -Novaprospekt (talk) 00:18, 4 July 2009 (UTC)
 * No, it would be a great idea to expand the article,

Block quote and you're most welcome to do it if you feel comfortable! Fvasconcellos (t·c) 03:00, 4 July 2009 (UTC)

Would be helpful if someone could add the same type of chart on other drug pages that shows K1 affinities on different receptors ... it's beyond my pay grade but I find it very helpful to compare how the antihistamines in particular have different binding affinities for serotonin, dopamine, muscarinic, and histamine receptors. — Preceding unsigned comment added by 58.176.147.203 (talk) 07:24, 25 June 2018 (UTC)

Incorrect Sectioning
There are some instructions under the section for "Side Effects" which seems improper to me. Shouldn't this be under it's own category or such? TheAdmiral (talk) 11:47, 21 May 2010 (UTC)

There is a notable use, local anesthetic, under pharmacology. I feel like this should be moved to the medical uses section instead? It seems like it would be a better fit there! Amassey1 (talk) 00:18, 26 February 2021 (UTC)

Clarity
I have no idea what this article is talking about. This, and many other articles on Wikipedia regarding medicine are overly technical and even clicking through links isn't helpful. I'm wondering if any other editors have brought this up before. ——Digital Jedi Master (talk) 04:55, 18 August 2010 (UTC)

Potentiating opiates?
The article says: "Also used to potentiate any opiates. Commonly combined with pethidine (AKA, meperidine, or Demerol) in a brand called Mepergan, a meperidine/promethazine combination. Also frequently used in conjunction with codeine, in a syrup form. The combination leads to more powerful euphoric effects than with codeine alone." But quotes no sources. What sources are there to back up this assertion? I am aware of antihistamines being used with opioidses to block the effects of the histamine release seen in some opioids. —Preceding unsigned comment added by 82.141.227.210 (talk) 10:41, 6 April 2011 (UTC)

Propose new article Phensedyl (currently redirects here)
I plan to write a new article Phensedyl, as searches for that brand name turn up a huge amount of coverage of abuse of that brand of cough syrup in South Asia, its banning by the Bangladeshi government in 1982, continued smuggling, etc. I brought this up as WPINDIA as well: Wikipedia_talk:Noticeboard_for_India-related_topics. If anyone else would like to help (especially with photos), that'd be awesome. Thanks for your time! MatthewVanitas (talk) 21:21, 19 July 2011 (UTC)

Does not belong
I think the whole bit about it adding euphoria to codeine does not belong on here, not only is it subjective, but it promotes codeine abuse — Preceding unsigned comment added by 99.174.194.165 (talk) 03:23, 22 March 2012 (UTC)

Potentiating opiates?
This needs clarification. Numerous sources state promethazine actually enhances sedation, but has no significant potentiation on opiates. Other older sources state that it does potentiate but at the level of the liver not the brain. This remains confusing. Nurses still give this drug to potentiate narcotics. Either the article should be expanded, or a separate page addressing this specific issue should be written. If a chemist or pharmacist would clear up this issue with citations it would be very much appreciated by practitioners. Execinfo (talk) 16:55, 7 January 2015 (UTC)
 * What nurse gives Phenergan to specifically potentiate opiates? If anything providers steer away from giving Phenergan in combination with opiates in lieu of Reglan or Zofran, in cases of nausea or headaches. There is definitely anecdotal evidence that drug-seekers feel Phenergan potentiates the high of opiates, but I would not put that as an indication for use. I have never heard of it being used in that way medically. Either way, it's definitely something to talk about on the page. It needs its own section, but not a separate page. UltraSunshine (talk) 12:48, 30 January 2015 (UTC)
 * I took it out of indications. I definitely think that it would be appropriate to mention somewhere else in the article.UltraSunshine (talk) 12:54, 30 January 2015 (UTC)
 * In the past, promethazine was used as an adjunct to anesthesia and as a synergistic agent for opiod analgesics, but that was decades ago. I only learned of that via military medical training and I did carry promethazine in the field, only using it twice in nearly 28 years and one of those times was a desperate measure in anaphylaxis, after 50mg of diphenhydramine was injected to poor effect, along with 10ml 10:10000 epinephrine IV. That was due to a delayed medical evacuation. In a military environment, it was one of my preferred drugs to carry in the field. I am unable to speak of its use in recreational usage, as that is far outside of my experience.Wzrd1 (talk) 20:19, 2 July 2015 (UTC)

External links modified
Hello fellow Wikipedians,

I have just added archive links to 1 one external link on Promethazine. Please take a moment to review my edit. If necessary, add after the link to keep me from modifying it. Alternatively, you can add to keep me off the page altogether. I made the following changes:
 * Added archive http://web.archive.org/web/20110718172715/http://www.cja-jca.org/cgi/reprint/6/4/375.pdf to http://www.cja-jca.org/cgi/reprint/6/4/375.pdf

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Cheers.—cyberbot II  Talk to my owner :Online 19:42, 28 February 2016 (UTC)

Missing side effect
One of the more serious potential side effects is photo-sensitivity. This means that people should not use sunbeds when taking this medication and should use extra protection. This effect was prominently noted on the last packet I received and someone should probably add this. I'm simply not up to the task. 81.97.100.208 (talk) 20:32, 11 April 2020 (UTC)

Recreational use ? What ?
"[promethazine] may also be used for sedating people who are agitated or anxious, an effect that has led to some recreational use (especially with codeine)." I don't understand how self-medicating agitation or anxiety with what's essentially a first generation anti-psychotic is "recreational use". There is categorically nothing recreational about dopamine antagonists or H1 antagonists. Drugs that have a similar -if not identical- pharmacological profile (haloperidol, loxapine) are notoriously aversive. → This phrasing should be modified to describe its mere presence in some codeine syrups, codeine being the only thing with a recreational value in such blends. 77.146.231.162 (talk) 11:46, 28 March 2023 (UTC)


 * @77.146.231.162
 * I tend to agree. All it does is reduce itchiness and knock you out. Also I find the drug quite pleasant to unwind on, although this is my own personal experience. Pikachu.447 (talk) 07:04, 5 May 2024 (UTC)

What is the neuroleptic potency of promethazine?
Can anyone give me more information on the neuroleptic potency of promethazine? On the German Wikipedia page it is given as 0.5, but in some other sources it is given as 0.1. There are even sources that claim that promethazine has no neuroleptic potency at all. Unfortunately, I do not have access to the source used in the German Wikipedia article. Hendrik1867 (talk) 17:06, 18 May 2023 (UTC)