Talk:Propranolol

structural chemistry of the beta-blockers
Replaced the phrasing "insertion of an aryloxy bridge" with "insertion of an oxymethylene group", as the former would seem to be obviously incorrect. Comparing propanolol with earlier attempts at beta blockers there is clearly no new or additional aryl group in propanolol, rather there is the insertion of -OCH2- between the naphthyl group and the (2-(alkylamino)ethanol) group. Thus "insertion of aryl[anything]" is self-evidently false. Unless I'm unaware of some historical - yet unfortunate - med. chem. terminology. — Preceding unsigned comment added by 71.202.140.109 (talk) 10:51, 28 March 2012 (UTC)

PTSD
A partition of the article, under "another move," needs to be put back in the article. The post traumatic stress disorder as well as difficulty remembering things is *VERY* important to this article as potential memory loss is a major side effect.

The argument against not leaving it in is some unverifiable cnn.com link that is broken about the united states surgent general saying that the findings were not impressive. However, that is not a very good argument as it is only one doctor and a possible bias one at that.

Even if there are arguments against its use for PTSD or difficulty remembering things, those arguments could be put into the article as well, along with the study and findings about its effects on memory. Wikipedia articles ought to be more in detail, not less. Sp0 (talk) 05:18, 27 June 2008 (UTC)


 * I agree that the PTSD research and impact on memory formation should be moved back into the article. Time gave reason to those who wanted to keep this information in the article: it's now published in Nature Neuroscience
 * http://www.technologyreview.com/biomedicine/22187/?a=f
 * (And yet it was removed from the article at the time... way to go).70.81.15.136 (talk) 08:05, 6 March 2009 (UTC)

Social Anxiety disorder
In the UK anyway, propanolol is very often prescribed to patients suffering from social phobia or social anxiety disorder. Maybe this should be added to the article. —Preceding unsigned comment added by 86.13.65.217 (talk) 19:59, 9 May 2010 (UTC)

———————————————

I live in Canada, and have been aware, since 1988, of propranalol's effectiveness for social anxiety and for anxiety disorders generally, including panic disorders. I have, as a psychologist, participated in treatments using this drug, of persons with PTSD, and found it to be invaluable in controlling the panic states and the generalized anxiety which are otherwise very intractable in clients with PTSD. The daily or twice daily doses needed to maintain a steady blood level, and thereby, to control fears and panic in a reliable way, are generally quite low -- much lower than the doses recommended to control high blood pressure, so that side effects are generally minimal. The only contra-indication to the use of this drug for anxiety disorders, that I know of, is unmanaged severe asthma, because beta-blockers can prevent effective emergency management of asthma. I have never seen any loss of memory in association with the use of this drug, but clients who maintain a steady blood level become able to experience their traumatic memories, without having those memories trigger a fear reaction.

Information about these effects is quite well known in the medical and psychiatric communities, and should be included in the article. I will check for suitable references, and post them when I have them. Janice Vian, Ph.D. (talk) 22:51, 6 February 2014 (UTC)

Moved
Moved from article: This is sometimes used, along with antipsychotics, in treating schizophrenia. Is it really? Propranolol is indeed effective against tremor, but I have never heard of any psychiatric use. Kosebamse 12:51, 27 Aug 2003 (UTC)

-- I was prescribed it for anxiety problems a few years ago.

--- It's commonly used for anxiety mainly because it slows and stabilizes your heart rate, in my understanding (and I am prescribed it for occasional use). Also this makes clear why it is mainly used for high blood pressure. But the effect of the drug breaks the feedback loop which encourages nervousness: heightened emotions/anxiety lead to increased heart rate, sweating, etc., all of which are cues back to your brain that there is something to be upset about. I didn't know of any direct psychotropic effect, if there is one it is very minor. It is certainly nothing like an atypical antipsychotic. If it's used in treating schizophrenia, it's definitely treating the symptoms, not the problem. There is also a significant black market for the drug especially among musicians because it pretty much completely cuts the nervousness and especially the hand shakes that accompany auditions for many people, even at a very low dose, resulting in a far less stressful playing experience and better performance. I am surprised the article doesn't mention that. 128.175.205.52 06:45, 13 July 2006 (UTC)

Another move
Moved from article: Propranolol, acting as a beta-blocker, has also been shown to have an effect on the formation of memories with strong emotional content. During very emotional or traumatic times, adrenaline and noradrenaline are released from the adrenal medulla which activate beta receptors in the brain. The effect is to give the associated memories more "force" due to the strong emotional content and subsequent beta-receptor activation. Propranolol blocks beta-receptor action, and thereby reduces or eliminates the emotional component of the memory. The effect is to make the memory more mundane.

Controversial use of the drug per recent CNN article. President's Council on Bioethics not impressed. http://www.cnn.com/2006/HEALTH/01/14/trauma.pill.ap/index.html. Might give someone false hope this drug can do something for them in this area. Also per McGaughy article, he doesn't know where memories are stored or how they are stored. It is another theory.


 * Supported, but next time please use edit summaries. JFW | T@lk  14:21, 19 January 2006 (UTC)


 * I've been on propranolol for 3 years, for me it works amazingly. I first noticed how well it worked after my grandpa died in 2003, everyone had a really hard time with it, I seemed to recover from the grief faster than everybody else. - Richard February 11, 2006 - 05:51, UTC

ive just been prescribed 10mg 3 times a day for problems i am having which seem to be down to stress and anxiety


 * What is the title of the CNN article? I stopped taking it after i read http://www.cognitiveliberty.org/neuro/memory_drugs_sd.html and this article that originally noted that url.

Sign!!!! %c2%a1 %c2%bf  %7e%7e%7e%7e
&#91;&#91; hopiakuta &#124; &#91;&#91; &#91;&#91;%c2%a1]] &#91;&#91;%c2%bf]] &#91;&#91; %7e%7e%7e%7e ]] -]] 02:31, 27 November 2006 (UTC)

Per [my impression of] a Sixty Minutes story {after John Philip Abizaid, & before Jay Greenberg}, propranolol reduces memory by reducing adrenaline. There are many issues, positive & negative, regarding employing propranolol to reduce post traumatic stress disorder {which could be an alternate connotation of hypertension}.

It is spelt like propane {or profane, pain?}, & lol, which seem somewhat emblematic of the claimed effects. Fascinating that it's half a century old.

&#91;&#91; hopiakuta &#124; &#91;&#91; &#91;&#91;%c2%a1]] &#91;&#91;%c2%bf]] &#91;&#91; %7e%7e%7e%7e ]] -]] 02:31, 27 November 2006 (UTC)

&#91;&#91; hopiakuta Please do  sign  your  signature  on your  message. %7e%7e  Thank You. -]] 04:54, 9 September 2007 (UTC)

Availability of propranolol medicine in INDIA as CIPLAR10 or CIPLAR40

Use as a treatment for anxiety
I added a note indicating that propranolol is occasionally used in the treatment of anxiety, but it has been removed. Why? I myself use the drug for such a purpose (prescribed) and I find it to be quite effective. It seems odd that the article now has absolutely no mention of this application of the drug, and a bit offensive, considering the fact that I added such a mention some time ago. Rev. Neil

Wait..."Control of tachycardia/tremor associated with anxiety..." That does touch on it, but perhaps this could be elaborated upon somewhat. Rev. Neil


 * Well I'm definitely no expert, but propranolol was once suggested to me to treat some symptoms of anxiety (I had to decline for other medical reasons.) As I understood it, non-selective beta blockers are pretty much a "universal" muscle relaxant. I know I feel less anxiety when muscles from the diaphragm up to my shoulders are relaxed. Makes breathing easier etc. (Please delete/edit this as you wish. Just some ideas for Rev. Neil... :) Jedku (talk) 11:14, 20 February 2009 (UTC)

Well My Daughter has been prescribed Propranolol for Anxiety 1 Tab 2x Daily as needed. I was looking for info on this drug in order to help her know when the right time to take it is but 1 sentence does not help —Preceding unsigned comment added by 74.245.121.114 (talk) 20:58, 23 March 2011 (UTC)

It appears to only affect the amygdala
Propranolol only seems to affect the amygdala, which controls learned fear responses. It doesn't affect your memories at all, just the anxiety reaction to them.

Anyone know for certain about this? I plan on using it, as I'm sure millions of others will rush to do now also. Dream Focus 03:21, 27 November 2006 (UTC)


 * It affects adrenaline, which is necessary for the fear memories to form in the amygdala. You have to take it when the event happens to you.  It doesn't work on long time anxiety sufferers like myself.  Worth mentioning is how cheap it is.  I got Propranolol and Celexa at Walmart, one of them two dollars and the other four dollars.  I forget which was which, but very cheap, since they are both out of patent and generics abound.

Dream Focus 08:23, 16 May 2007 (UTC)


 * I'm not convinced that it only affects adrenaline. Anyway, doesn't it affect the receptors, not adrenaline, which is different and could turn out to have other consequences. Recent research seems to be concluding that every time we remember something we remove the emotional memory and then restore it, which fits with the idea of catharsis in therapy. Post-traumatic stress disorder is being treated by getting patients to recall events with the emotion while taking propranolol, so it would be expected to work on anxiety resulting from old traumas as well as current events. There is much reference to propranolol as inhibiting conscience and guilt, and I would not be surprised if there was more to discover here. My personal suspicion is that people I have known have changed subtly in personality while on propranolol, and a friend described how, looking back, he had a different attitude to people, about which he was now unhappy. Read the links I added under the new section on conscience etc where it is being suggested that propranalol could alter the fabric of society on which all our interactions are based. --Memestream (talk) 10:35, 11 April 2008 (UTC)

Recent News: Will U.S. Military use it for PTSD?
Here's a new link with information regarding possible use for military PTSD sufferers: http://www.military.com/veterans-report/drug-hopes-to-treat-veterans-trauma?ESRC=vr.nl Ricojonah 21:58, 6 May 2007 (UTC)

Type 2 diabetes
I fail to see the evidence for propranolol provoking type 2 diabetes. The given sources certainly don't do it.. —Preceding unsigned comment added by 88.112.192.38 (talk) 15:39, 11 May 2008 (UTC)

From the source: "An additional concern is the increased risk of developing diabetes, particularly with the combination of a beta-blocker with a thiazide-type diuretic."

Notice the "with the combination" part.. —Preceding unsigned comment added by 88.112.192.38 (talk) 15:45, 11 May 2008 (UTC)

The links to diabetes seem vague. The reference is as vague as it is in the wiki article. The reference material only refers in the following sentence. "The decision not to recommend Beta-blockers for first line therapy is based on evidence that suggests that they perform less well than other drugs, particularly in the elderly, and the increasing evidence that the most frequently used Beta-blockers at usual doses carries an unacceptable risk of provoking type 2 diabetes." This doesn't refer to being used in combination with a "thiazide-type diuretic." Petoman 99 (talk) 08:14, 5 April 2013 (UTC) Peter

Banned in Sport
given that it has now caused someone to be stripped of an olympic medal, can someone tell us why it is banned- what it does that is so good for sportspeople.IceDragon64 (talk) 17:21, 17 August 2008 (UTC)

Anxiety by the looks of it, anxiety is completely out of the question as long as you are taking it, this will make most of your reactions and your technique near flawless. Adrenaline as awesome as it is, it can really mess up your technique, anticipation of hitting a ski jump for example, the launch, the landing, the twists and spins. With this drug in your system, you just do it. Almost android like. —Preceding unsigned comment added by 142.162.183.162 (talk) 22:14, 23 October 2010 (UTC)

Avlocardyl drug name
I changed the blatently incorrect drug name in the first paragraph "Avlocardyl mentally handicapped" to the correct name "Avlocardyl Retard", but this change was quickly undone and deemed to be 'unconstructive'. The phrase "retard" in drug names is used to denote a longer or 'retarded' duration of release of the drug, and has absolutly nothing to do with the phrase 'mentally handicapped'. I feel that leaving this drug with the phrase 'mentally handicapped' after it is entirely misleading and a blatant error. —Preceding unsigned comment added by 77.44.18.174 (talk) 00:45, 11 February 2009 (UTC)

Nebivolol?
"Newer, more selective beta-blockers (such as nebivolol) are now used in the treatment of hypertension."This name-dropping of nebivolol strikes me as possible astroturf advertising. It's true that propranolol is rarely used for hypertension anymore, and that it's been supplanted by beta1-specific drugs - but the common examples that come to mind are atenolol and metoprolol, both older drugs that are in ubiquitous use. Nebivolol is a new drug, just coming on the market (as Bystolic), that is still rarely used. And it happens to be the subject of a major advertising campaign by it's maker, with multi-page glossy ads in JAMA and other major journals every week for a while now. If a specific example of a widely-used beta1-selective drug is required I'd suggest atenolol or metoprolol instead.

Recent News: Suicide by Proprandolol
Apparently accused killer Lynn Turner committed suicide by taking an overdose of Proprandol. See: http://www.ajc.com/news/cobb/lynn-turners-death-ruled-614092.html?cxntlid=cmg_cntnt_rss —Preceding unsigned comment added by 130.221.224.5 (talk) 17:31, 15 September 2010 (UTC)

Propranolol is banned in the Olympics because it lessens hand tremors in, e.g., archery. — Preceding unsigned comment added by 99.190.133.143 (talk) 17:51, 23 March 2012 (UTC)

Secretion of Propranalol
How is propranalol secreted? — Preceding unsigned comment added by 195.194.36.193 (talk) 12:23, 14 May 2012 (UTC)

prppranolol
i want to khnow what is the absorption wavelenght in uv for some drugs as prppranolol — Preceding unsigned comment added by Maryamabi (talk • contribs) 12:36, 30 April 2013 (UTC)

Hewey's "wool"
The WSJ link provided by the ip editor does not mention propranolol. Just because an author has gotten some recent press does not mean we put every mention of their plot devices in medical articles. This reference, to me, does not seem to ne particularly notable, so I have removed it, but if someone can demonstrate otherwise, here would be the place to discuss it before replacing it in the article. -- [ UseTheCommandLine  ~/ talk  ]# &#9604; 16:19, 19 September 2013 (UTC)

In 2007, the Center for Automation in Nanobiotech (CAN) outlined the hardware and software platform that would one day allow robots smaller than human cells to make medical diagnoses, conduct repairs, and even self-propagate.

In the same year, the CBS network re-aired a program about the effects of propranolol on sufferers of extreme trauma. A simple pill, it had been discovered, could wipe out the memory of any traumatic event.

At almost the same moment in humanity’s broad history, mankind had discovered the means for bringing about its utter downfall. And the ability to forget it ever happened.

https://www.evidence.nhs.uk/medicine/fluocortolone?om=[{%22men%22%3A[%22%20apomorphine%20%22]}%2C{%22men%22%3A[%22%20propranolol%20%22]}%2C{%22men%22%3A[%22%20wool%20fat%20%22]}]

Need more????????? — Preceding unsigned comment added by 71.236.134.156 (talk) 04:02, 2 October 2013 (UTC)

Amygdala + racism
I removed the following from the article:

"many psychologists think racist feelings are driven by the fear center"

The statement wasn't referenced, and is factually incorrect. It's not possible to know what brain regions generate a thought or feeling, only to know what brain regions are associated with it. The actual cause may be different.

Stjep (talk) 18:09, 28 May 2015 (UTC)

Structural and ball-and-stick diagrams disagree?
Ball-and-stick shows two joined rings with one hydrogen per carbon. The structural diagram shows two double bonds on the first ring rather than three. I think that's probably the mistake (the double bonds should be rotated one place and one more added). Or I could be misreading it altogether. — Preceding unsigned comment added by 71.109.144.96 (talk) 01:32, 14 October 2015 (UTC)
 * The images are resonance structures, each accurately and equivalently depicting the same chemical compound. The diagram File:Benzene_delocalization.svg shows the equivalence in the simplest case, benzene.  -- Ed (Edgar181) 13:22, 14 December 2015 (UTC)

Ways to remember it
Drug addicts use the jargon "soprano lol" because they get it easier. — Preceding unsigned comment added by 2A02:587:4100:1D00:C1B9:9BD3:2349:642 (talk) 23:13, 13 December 2015 (UTC)

External links modified
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I have just added archive links to 1 one external link on Propranolol. Please take a moment to review my edit. If necessary, add after the link to keep me from modifying it. Alternatively, you can add to keep me off the page altogether. I made the following changes:
 * Added archive {newarchive} to http://www.sciam.com/article.cfm?chanID=sa004&articleID=0006783F-2CFE-1FE2-ACFE83414B7FFE9F&pageNumber=1&catID=4

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Incorrect info in Medical Uses/Cardiovascular
"Propranolol is not recommended for the treatment of hypertension by the Eighth Joint National Committee (JNC 8) because a higher rate of the primary composite outcome of cardiovascular death, myocardial infarction, or stroke compared to an angiotensin receptor blocker was noted in one study.[12]"

Reference 12 does not specifically mention propranolol but just beta blockers in general and the study that decision was based on (Lancet. 2002 Mar 23;359(9311):995-1003. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.) didn't compare to propranolol, it compared to atenolol. — Preceding unsigned comment added by 161.69.123.10 (talk) 21:13, 3 December 2018 (UTC)

Treatment of racism and bias
This drug has been noted in the press as an experimental treatment for racism and bias. For example and. -- Beland (talk) 03:44, 20 October 2020 (UTC)