Talk:Protein/Archive 2

Archived
Since there were no edits to the talk page since January 4 and it was 90+ kbs long, I archived the talk page. Quadzilla99 10:49, 27 January 2007 (UTC)
 * But the talk page was such an interesting study in the sciences! I understand the issue with the length, but I'd like to advertise here that it's an interesting read if only to see the various cognitive models on display by the posters. 66.93.3.210 04:28, 7 March 2007 (UTC)

Picture
Just wanted to point out that moving pic. it distructs a little when you are trying to read the text.. and i thing i read somewhere some rules what a proper page should/should not contain and i think i didnt recommand animations faster than 1move/3seconds..--91.127.232.51 19:33, 7 November 2007 (UTC)

Importance scale
Incidentally shouldn't this be rated as core on the importance scale? Quadzilla99 10:52, 27 January 2007 (UTC)
 * What? There's an importance level above 'top'? These assessments are starting to sound like coffee sizes at Starbucks. Opabinia regalis 05:22, 28 January 2007 (UTC)
 * Maybe I'm wrong I know they have a core group for biographies such as Michael Jordan and others let me check. Quadzilla99 06:20, 28 January 2007 (UTC)
 * Top is the highest level for these categories. Only biographies have the "core" level that I see. Quadzilla99 23:43, 30 January 2007 (UTC)
 * Top sounds good to me. Eganio (talk) 23:31, 21 November 2007 (UTC)

where are proteins made?joseph deloria june 20,2007
 * Proteins are made in the cell's cytoplasm by ribosomes. See the article on translation for more info. Eganio (talk) 23:31, 21 November 2007 (UTC)

Examples
Would a section listing three or four examples of proteins with a one-sentence description of their specific functions improve this article? Bob Enyart, Denver radio host at KGOV (talk) 17:20, 21 September 2012 (UTC)

Proteins known as antibodies provide protection from disease.
Proteins known as antibodies provide protection from disease.Without proteins, no organism could exist,so proteins are the LAST category of organic molecules to be burned as fuel.Why I thought that first we burn alcohol,then proteins,then carbohydrates,then fat(lipid).What you kids ;) think?--Thank you.MD.Brian (talk) 05:51, 31 January 2008 (UTC)
 * First we burn sugars/carbohydrates. Next we burn fat.  Then we burn protein.  We do not burn alcohol for energy, we burn it to detoxify it as a poison.  Burning alcohol produces heat as a byproduct.  --Agesworth (talk) 09:27, 1 February 2008 (UTC)

Protein
Refer from Buffering agent, which said: "Buffering agents in humans, functioning in acid-base homeostasis, are extracellular agents (e.g., bicarbonate, ammonia) as well as intracellular agents (including proteins and phosphate)." The important thing is, what kind of protein in the cell of human body that work as a buffer? I think this Protein article should be expanded to cover that kind of example... Ivan Akira (talk) 10:21, 16 March 2008 (UTC)

Disambiguation is not a disambiguation
The page has a reference to a disambiguation page, but the disambiguation page is not really a disambiguation page, but merely a list of protein-related topics. Also, I don't see why the link to protein in nutrition is placed under the title. I suggest renaming protein (disambiguation) into "protein-related topics" or similar. Consider making it a category. I would do these myself, but don't know how to do them. CuriousOliver (talk) 12:05, 28 April 2008 (UTC)
 * The dab page looked fine to me.Asher196 (talk) 13:36, 28 April 2008 (UTC)

Lead picture
The lead picture is a poor choice. A protein is not a cartoon representation of its backbone. The colouring serves no useful purpose for the lead. This picture might be better located at Protein structure, and another image, such as a surface depection, or an all atom model, would be better here. Agesworth 02:44, 28 December 2008 (UTC)

"built from 20 different L-α-amino acids" ?
The line "Proteins are linear polymers built from 20 different L-α-amino acids." sounds a bit misleading. It might suggest that each of the 20 different amino acids needs to be in place, or that there are always exactly 20 amino acids used. So I suggest changing it to "Proteins are linear polymers built from series of up to 20 different L-α-amino acids." JH-man (talk) 15:02, 3 February 2009 (UTC)
 * Then do it.--Atemperman (talk) 04:57, 5 March 2009 (UTC)

In the shop for repairs
I'll attempt to bring this important article back to GA status. I've got shelves of biochem textbooks at arms length around me, so it shouldn't be too hard to add references for everything and expand the text a bit. Sasata (talk)

VANDALISM: The paragraph on synthesis has been vandalised; april 20, 09 —Preceding unsigned comment added by 84.120.173.238 (talk) 07:08, 20 April 2009 (UTC)
 * Fixed - thanks for the heads-up. Sasata (talk) 07:33, 20 April 2009 (UTC)

Sentence I don't understand
"The residues in a protein are often chemically modified by post-translational modification, which can happen either before the protein is used in the cell, or as part of control mechanisms"

Maybe it's because of my lack of english, but I don't understand what is meant with this. What are 'control mechanisms'? or does it mean 'as part of the control of mechanisms' ? Kasper90 (talk) 11:27, 21 April 2009 (UTC)
 * Thanks for the feedback. Have reworded to say: "Shortly after or even during synthesis, the residues in a protein are often chemically modified by post-translational modification, which alter the physical and chemical properties, folding, stability, activity, and ultimately, the function of the proteins." Is that better? Sasata (talk) 17:49, 21 April 2009 (UTC)
 * Yeah, much better, thank you :)! Kasper90 (talk) 13:18, 22 April 2009 (UTC)

Cellular functions
I think this part of the article is too much about the binding properties of the protein. I think the first paragraph should just summarize all the different functions of proteins in a cell, because that's what you expect to read there. —Preceding unsigned comment added by 115.132.30.240 (talk) 18:13, 23 April 2009 (UTC)

Layman's Overview
The page is so technical that it is largely unapproachable to anyone without a knowledge of chemistry for a word and term that is used in everyday language. A concept as fundamental to nutrition as this should have a leading description that is approachable for those whose education extends to high school, with progressively more detailed content following. —Preceding unsigned comment added by Shatuga (talk • contribs) 12:54, 14 December 2009 (UTC)


 * Hi, perhaps you were looking for Protein (nutrient)? Graham Colm Talk 12:59, 14 December 2009 (UTC)

Confused
This probably isn't that relevant to the page, but in the game Mass Effect 2 they refer to some (alien) species as being either dextro- or levo- protein (or DNA). What does this mean?--86.145.128.26 (talk) 23:03, 18 February 2010 (UTC)


 * See Amino_acid --Kkmurray (talk) 23:55, 18 February 2010 (UTC)

Someone change this Text in article: Data supports that some protein structures fold into a highly rigid structure Change to: Data supports the conjecture that some protein structures... —Preceding unsigned comment added by 24.108.38.16 (talk) 20:52, 29 September 2010 (UTC)

Maintenance checks
Proteins (also known as polypeptides) are organic compounds gay shit heads amino acids arranged in a linear chain and folded into a globular form. ...

Ironically enough when you Google "Proteins" that ↑ is what comes up on Google, and I'm pretty sure the bold word do not need to be there. I checked over the document and I couldn't find that phrase or anything else inappropriate, but I'm not entirely sure how to remove that from the Google search :/ still hopefully some one can remove that!

If you have any concerns please visit my User-Page (talk) 18:59, 10 November 2010 (UTC)


 * Yes, it seems Google is currently indexing this vandalised version from the 7 November. This is odd because Google is usually quite quick at updating. Graham Colm (talk) 19:11, 10 November 2010 (UTC)

Length of intro
The lead of this article seems way too long. There are 4 long paragraphs before the table of contents - really this should just be one or two sentences. Someone with more time and knowledge of the subject than me should move some of the text into the main body of the article. Bazonka (talk) 19:38, 15 January 2011 (UTC)
 * The article length is more than 30,000 characters, and so a four-paragraph lead is perfectly appropriate. See WP:Lead. Sasata (talk) 19:46, 15 January 2011 (UTC)

Adopt an orphan
Monopolin has been an orphan protein since the winter of 2009. "Mono" means "lonely" in Greek... Will spring 2011 bring hope? You can make a difference. walk victor falktalk 11:14, 10 April 2011 (UTC)

Edit request from Aramirez1, 26 May 2011
Aramirez1 (talk) 18:56, 26 May 2011 (UTC)
 * This request is empty. You will have to specify what change you would like made to the article.  Deli nk (talk) 19:07, 26 May 2011 (UTC)

Peptide Bond
I like the split image approach used in this figure. It's a good way to relate the chemical structure to a pymol-style rendering: The only catch is that the image on the left clearly highlights the entire amino acid backbone, complete with the alpha carbon and sidechain. Whereas the one on the right specifically circles the peptide bond. This figure implies that the same area is highlighted in both images. I have a few ideas for new figures for this page, I guess I'll start by revising this one. Check back tomorrow to see what I've come up with. I(q) = User(q)·Talk(q) 00:56, 4 September 2011 (UTC)


 * How about this?
 * PEPTIDE-BOND-FIGURE.png and an adjacent amino acid (top/inset)]]


 * Does something along these lines work? I was mainly going for clarity with this one. I(q) = User(q)·Talk(q) 02:13, 4 September 2011 (UTC)
 * Oops. I've inadvertently drawn alternating D and L isomers! That's what I get for making a figure late at night!! I(q) = User(q)·Talk(q) 15:02, 4 September 2011 (UTC)
 * Fixed! I(q) = User(q)·Talk(q) 15:17, 4 September 2011 (UTC)
 * How about this (below) version? I(q) = User(q)·Talk(q) 14:50, 5 September 2011 (UTC)



Class
This article is about a class of molecules. Is this a colloquial expression or are proteins really "an official class" of compounds. If yes: Where can I find a written statement of that? Thanx Grey Geezer 15:37, 26 November 2011 (UTC) — Preceding unsigned comment added by Grey Geezer (talk • contribs)

wow
i dont understand one word on that page. whoever wrote that is a geinus, but dumb it down please, for the morons (me). Jake1993811 (talk) 06:18, 31 December 2011 (UTC)


 * Try WP/Simple hydnjo (talk) 15:52, 31 December 2011 (UTC)

Edit request on 6 March 2012

 * Structural Biology Knowledgebase: annotations for every known protein molecular structure.

Shahraship (talk) 19:50, 6 March 2012 (UTC)
 * Red question icon with gradient background.svg Not done: please be more specific about what needs to be changed. -- Red rose64 (talk) 19:54, 6 March 2012 (UTC)

Is the main link misspelled?
I am absolutely no expert in Biology or Wikipedia editing (this is my fist comment), but is the main link to this article misspelled?

http://en.wikipedia.org/wiki/Protiens

Inside the article, it is titled "Proteins" not "Protiens". Are there two ways of spelling it, or am I not seeing/understanding something? — Preceding unsigned comment added by Treyr (talk • contribs) 12:30, 17 September 2012 (UTC)
 * "Protiens" is simply a redirect page. Many articles have redirects that point from common typos to the correctly titled article.  You may want to take a quick look at WP:Redirect, which describes how wikipedia redirect pages work. (+)H3N-Protein\Chemist-CO2(-) 02:56, 19 September 2012 (UTC)

Biotechnology portal link?
Would anyone mind if I added the infobox to this page? At the top? Is there a better portal or infobox to use?Saltwolf (talk) 00:53, 19 October 2012 (UTC)

Primary sources vs. reviews
A good primary source can be more important than a bunch of reviews in my view. David P Minde (talk) 19:45, 30 December 2012 (UTC)
 * Perhaps, but without any specifics, this comment would be more appropriate at Wikipedia talk:No original research. Sasata (talk) 20:49, 30 December 2012 (UTC)

3D prediction from genomic sequence
In my view, the Evfold algorithm is one of the most noteworthy achievements in structural biology in the last decade and should be at least briefly mentioned in the prediction section. Other views? thanks! David P Minde (talk) 20:51, 30 December 2012 (UTC)
 * Do you know of any secondary sources that support your view? Sasata (talk) 21:15, 30 December 2012 (UTC)

Sure, many: you can look into citations, a most favourable "Faculty1000" comment, extraordinarily active scholarly reception and the like. cheers, David P Minde (talk) 14:28, 1 January 2013 (UTC)
 * If you want to add this (and I'm not convinced it belongs in a general overview article on proteins), then the onus is on you to supply the citations. Sasata (talk) 16:40, 1 January 2013 (UTC)

http://www.scopus.com/results/citedbyresults.url?sort=plf-f&cite=2-s2.0-82855163967&src=s&imp=t&sid=4A729E29AA436A150098074A1F9C7581.I0QkgbIjGqqLQ4Nw7dqZ4A%3a30&sot=cite&sdt=a&sl=0&origin=inward&txGid=4A729E29AA436A150098074A1F9C7581.I0QkgbIjGqqLQ4Nw7dqZ4A%3a2

David P Minde (talk) 16:47, 1 January 2013 (UTC)
 * Which one of those articles can be used to support your contention that "the Evfold algorithm is one of the most noteworthy achievements in structural biology in the last decade"? Sasata (talk) 17:12, 1 January 2013 (UTC)

e.g. Deciphering membrane protein structures from protein sequences. Flock T, Venkatakrishnan A, Vinothkumar K, Babu MM. Genome Biol. 2012 Jun 27;13(6):160. [Epub ahead of print] PMID: 22738306 [PubMed - as supplied by publisher] David P Minde (talk) 06:35, 3 January 2013 (UTC)

Edit request on 5 February 2013
Protein is considered an important body fuel.Rme09 (talk) 13:21, 5 February 2013 (UTC)


 * Can you please be more specific about your request? Specify what text should be removed and a verbatim copy of the text that should replace it.  Deli nk (talk) 13:25, 5 February 2013 (UTC)
 * See also protein (nutrient). Sasata (talk) 14:33, 5 February 2013 (UTC)

Amino acids vs amino acid residues
Peptides and proteins do not contain amino acids. That much all biochemists and chemists agree on. The article probably should make this point clear. In fact, I think that free amino acids are rare in nature. The key term is amino acid residue. Possibly if this term were introduced, there would be less confusion. On the other hand possibly other editors find this distinction to be pendantic. --Smokefoot (talk) 04:26, 10 November 2013 (UTC)
 * Oddly, I agree with your edit, but not your edit summary. Proteins (or at least polypeptides) are literally polymers of amino acids despite the fact that they don't contain intact amino acids. In the same sense, polystyrene is a polymer of styrene, even though it contains styrene residues, not literally intact styrene monomers. This is of course 1000 times more pedantic than your original argument. (+)H3N-Protein\Chemist-CO2(-) 15:54, 12 November 2013 (UTC)

External links modified
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 * Added archive https://web.archive.org/20110601003507/http://www.expasy.org:80/NAR/enz00.pdf to http://www.expasy.org/NAR/enz00.pdf

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Semi-protected edit request on 21 October 2015
Source:

A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than about 20-30 residues, ...

Edit request: Second sentence, sub phrase "less than about 20-30 residues," should be improved for clarity. Less than 'approximately' 'an approximation' is redundant. No need to specify "about" when you're saying "20-30," it is already understood this is an approximation. This gives the idea that it is not, in fact, 20-30, but perhaps 18-25, or 21-32, etc. If such is the case, it should be specified, not assumed.

Thank you.

CDaly89 (talk) 00:47, 21 October 2015 (UTC)
 * Yes check.svg Done Altamel (talk) 01:30, 21 October 2015 (UTC)

Should explain what a secreted protein is
Other WP articles refer to secreted protein but this article does not explain what that is. eg. Is it all except structural proteins and transmembrane proteins ? Could have a Classification section ? - Rod57 (talk) 22:55, 12 October 2016 (UTC)

lead too long Tag
I have tagged the article with a lead too long tag. My edit conforms to WP:LEADLENGTH and should not be reverted without providing a good reason. Also, at the time the article got promoted to GA‐status, the lead was shorter then it is now. —MartinZ02 (talk) 13:51, 19 July 2016 (UTC)
 * What do you think should be removed from the Lead? Graham Beards (talk) 20:07, 19 July 2016 (UTC)
 * Of the 5 current paragraphs : perhaps para 5 be deleted/moved to the related section, and para 3 be moved into its own new section on protein lifecycle/degradation ? - Rod57 (talk) 23:03, 12 October 2016 (UTC)

External links modified
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Should list protein size, in molecular weight as well as amino acids
Biology is aided by numeracy, yet many protein pages contain no information on protein size. What would it take to include the molecular weight (in daltons) and number of amino acids in the summary boxes for individual proteins? Or a range, for protein families? Newbie editor here, so apologies if this isn't the right venue for such an question. — Preceding unsigned comment added by 209.6.212.166 (talk) 03:40, 28 June 2018 (UTC)

Semi-protected edit request on 6 April 2019
When looking up "protein" on google, the little wikipedia section describes it as a nutrient. It is not. It is only a collection of nutrients in a colloquial sense. A protein is a biological molecule composed of amino acids to perform a certain function. Enzymes are not nutrients, but they are proteins. I suggest that it says "Protein [↵] Biological molecule" RuskiyJohn (talk) 20:47, 6 April 2019 (UTC)
 * Red information icon with gradient background.svg Not done: The Google excerpt is not about this article, it's about Protein (nutrient) and points to that. – Þjarkur (talk) 22:43, 6 April 2019 (UTC)
 * And yet it's still semi-protected. Does it need to be at this point? tsilb (talk) 03:10, 16 October 2019 (UTC)

lead is too long
Everything in this article can be simplified and to reduce its word count. — Preceding unsigned comment added by FreeHKK (talk • contribs) 15:22, 30 September 2020 (UTC)

Semi-protected edit request on 18 December 2020


203.189.185.78 (talk) 19:02, 18 December 2020 (UTC)
 * Red question icon with gradient background.svg Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. SK2242 (talk) 19:13, 18 December 2020 (UTC)

Semi-protected edit request on 29 July 2021
Change 'that are comprised of one or more long chains' in the first sentence of the protein article to 'that comprise one or more long chains'. This is because 'comprise of' is ungrammatical/non-standard usage. 111.65.69.148 (talk) 14:59, 29 July 2021 (UTC)
 * Red information icon with gradient background.svg Not done for now: please establish a consensus for this alteration before using the template. I think it's fine. It is a standard usage. Comprised of goes into detail. ScottishFinnishRadish (talk) 15:05, 29 July 2021 (UTC)

"Fish protein" listed at Redirects for discussion
An editor has identified a potential problem with the redirect Fish protein and has thus listed it for discussion. This discussion will occur at Redirects for discussion/Log/2022 February 1 until a consensus is reached, and readers of this page are welcome to contribute to the discussion. Steel1943 (talk) 01:27, 1 February 2022 (UTC)

"High protein" listed at Redirects for discussion
An editor has identified a potential problem with the redirect High protein and has thus listed it for discussion. This discussion will occur at Redirects for discussion/Log/2022 February 1 until a consensus is reached, and readers of this page are welcome to contribute to the discussion. Steel1943 (talk) 05:21, 1 February 2022 (UTC)

"Plant protein" listed at Redirects for discussion
An editor has identified a potential problem with the redirect Plant protein and has thus listed it for discussion. This discussion will occur at Redirects for discussion/Log/2022 February 1 until a consensus is reached, and readers of this page are welcome to contribute to the discussion. Steel1943 (talk) 06:25, 1 February 2022 (UTC)

"Single protein" listed at Redirects for discussion
An editor has identified a potential problem with the redirect Single protein and has thus listed it for discussion. This discussion will occur at Redirects for discussion/Log/2022 February 1 until a consensus is reached, and readers of this page are welcome to contribute to the discussion. Steel1943 (talk) 06:32, 1 February 2022 (UTC)

Portals
There is a stupidly broad range of portals listed. This is one of the many problems with WP. Some editors want to link everything directly to everything else. 43.249.196.194 (talk) 05:16, 6 November 2022 (UTC)
 * Red question icon with gradient background.svg Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Which ones do you believe should be removed? &#128156; melecie   talk  - 05:37, 6 November 2022 (UTC)
 * You fool. Take a look!  At least two thirds have only a very tenuous relationship to the article!!! 103.21.175.109 (talk) 05:43, 6 November 2022 (UTC)
 * Reliable source??? LOOK AT IT!!  It is basic stuff that does not need a source.  FFS. 103.21.175.109 (talk) 05:44, 6 November 2022 (UTC)
 * If you don't know which ones need to removed you should npt be editing WP! 103.21.175.109 (talk) 05:45, 6 November 2022 (UTC)
 * Red information icon with gradient background.svg Not done for now: please establish a consensus for this alteration before using the template. Given that your edit request is unclear as to what you're requesting, it cannot be acted upon. If you're asking that specific portals be removed, it would help to list which ones and why. "There is a stupidly broad range of portals listed" isn't actionable, and a discussion as to which, if any, should be removed is probably warranted. Aoidh (talk) 07:08, 6 November 2022 (UTC)

Low protein
Low protein is very harmful for our bones and muscles. It can be very painful if serious. 45.123.160.162 (talk) 13:55, 6 November 2022 (UTC)

Function of proteins
Voice 41.191.107.156 (talk) 06:31, 12 December 2022 (UTC)

Classification of proteins
There is no column in this regard in the wiki page for proteins. Light Green Botanist (talk) 11:57, 26 January 2023 (UTC)