Talk:Quetiapine/Archive 3

Clearly activism and lack of neutrality in this article:
Unsurprisingly, it's semi-protected.

"Despite being widely used as a sleep aid due to its sedating effect, the benefits of such use do not appear to generally outweigh the side effects." Here, "do not" appear should be replaced with "may".

"Off-label prescriptions, e.g. for chronic insomnia, of low-dose quetiapine is not recommended due to the harmful side-effects." This should be deleted. There is a possibility that some experts and some wikipedia editors don't know more than the doctors who perscribe this drug (mostly an antihistamine at low doses) over other options like physically addictive benzos.

More blatantly inappropriate is, "Owing to the risks associated with clozapine (e.g. agranulocytosis, diabetes mellitus, etc.), clinicians often attempt treatment with quetiapine first, although the evidence to support quetiapine's use for this indication is significantly weaker than that of clozapine." There should be a period, rather than a comma, after "first". Anyone who knows the first thing about clozapine (or is capable of researching it), understands that it is a drug of last resort. The drug carries 5 black box warnings and requires constant blood monitoring FFS. CloudBoy9001 (talk) 05:41, 4 July 2022 (UTC)


 * So provide sources for those statements, as is necessary for wikipedia. Ibanix (talk) 02:16, 22 October 2022 (UTC)

Semi-protected edit request on 19 March 2023
'his' --> 'this'

[...]If so, than quetiapine can compete with **his** reuptake activity preventing release of norepinephrine through NET to some extent.[...] RhysLowry (talk) 01:59, 19 March 2023 (UTC)
 * ✅ Thank you, - FlightTime  ( open channel ) 02:02, 19 March 2023 (UTC)

Potentially repost
Hello everyone🙂 The community made me aware, that my english is sometimes horrible😁 but I guess, my Post below hasn't that much grammatical errors then other posts from me😁so if someone wants to make that effort for me to proofread my article, heres the article:

(again, thank you for the effort, if you mentioned proofreading this😁)

Amphetamine is well known for being an agonist at the TAAR1 receptor inside a dopaminergic neuron,so the TAAR1 receptor signals through two different proteinkinases whether the DAT transporter inhibits the monoamine reuptake or acts in reversal. There is little evidence that the TAAR1 receptor co-localizes and signalling also to the NET transporter. If so, than quetiapine can compete with this reuptake activity preventing release of norepinephrine through NET to some extent. With a NET occupancy of 35% with quetiapine XR 300 mg/day, most likely quetiapine isn't capable of inducing a competitive answer to amphetamine exposure, but maybe can have calming effects. Materie34 (talk) 19:04, 7 April 2023 (UTC)


 * The article on quetiapine does not presently mention these receptors or transporters, so including it would really need a citation to published scientific literature, especially information such as the occupancy of NET at that dose of quetiapine. I strongly doubt that reliable measurements of NET occupancy even exist - it would have to be a calculated value based on measured affinities in isolation and an assumed concentration of drug.
 * This article is not suggesting that quetiapine might be capable of mitigating the effects of amphetamine, so why do you believe that speculation about it being not capable of doing that is needed? Verytas (talk) 03:17, 8 April 2023 (UTC)
 * hmm like I said Im interessted in pharmacology, and to be honest, it gives/gave good feelings to see an article on a pharmacology side. Also this was an article which (I guess) takes the second place of my articles in case of orthograph/grammatical mistakes. Also my Intention wasn't vandalism so I looked at the methylphenidate site and this site also mention that effect, so I thought that this information is good enough for wikipedia Materie34 (talk) 04:13, 8 April 2023 (UTC)
 * to see an article from me
 * Materie34 (talk) 04:14, 8 April 2023 (UTC)
 * I looked at the page on methylphenidate, and that page is describing an altogether different effect. Attributing that effect to quetiapine is just not valid, even if is true for methylphenidate. Verytas (talk) 05:55, 9 April 2023 (UTC)

Semi-protected edit request on 16 May 2023
It is written faeces instead of feces. 213.226.59.102 (talk) 19:15, 16 May 2023 (UTC)
 * ✅ Hyphenation Expert (talk) 19:41, 16 May 2023 (UTC)

Semi-protected edit request on 21 September 2023
Please change "Quetiapine...the treatment of schizophrenia, bipolar disorder, borderline personality disorder, and major depressive disorder." back to "The article starts with "Quetiapine...the treatment of schizophrenia, bipolar disorder, and major depressive disorder."

Explanation

The article states "Quetiapine, sold under the brand name Seroquel among others, is an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder, borderline personality disorder, and major depressive disorder.[7][8]" citing:

[7]"Quetiapine Fumarate". The American Society of Health-System Pharmacists. Archived from the original on 29 August 2017. Retrieved 26 March 2017.

[8] Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S (December 2010). "Second-generation antipsychotics for major depressive disorder and dysthymia". The Cochrane Database of Systematic Reviews (12): CD008121. doi:10.1002/14651858.CD008121.pub2. PMID 21154393.

Neither source discusses the use of quetiapine in the treatment of borderline personality disorder (BPD). An offshoot of [7] on a different web page, under "Related Treatment Guides" states:

"As with psychotherapy, there is no single medication that is clearly helpful in borderline personality disorder. Instead, medication is usually used to treat symptoms as they emerge or to treat other disorders that may be present (such as a mood or anxiety disorder or a substance abuse problem).

''There is little evidence that antidepressants help with the core symptoms of borderline personality disorder, but they may be useful if there are clear symptoms of depression and anxiety. There is more evidence that mood stabilizers and antipsychotics improve problems with impulse control, aggression or distorted thinking. The benefits are modest and should be weighed against the adverse effects of these drugs."''

with quetiapine listed as one option of antispychotics "in some way related to or used in the treatment of this condition". Its effect and efficacy on BPD, however, are not discussed so the article needs to either be amended with the correct sources expanding on the role the drug has on treatment, or the statement needs to be redacted. DewWhile (talk) 05:05, 21 September 2023 (UTC)
 * ✅ Tollens (talk) 05:36, 21 September 2023 (UTC)