Talk:Quinolone antibiotic

Serious reworking of this article needed.
MOVED FROM THE DISCUSSION PAGE ON THE QUINOLONE ARTICLE TO THIS ARTICLE 5-2011 DUE TO CREATION OF THIS SEPARATE ARTICLE.Davidtfull (talk) 03:44, 6 May 2011 (UTC)davidtfull

This edit began with disambiguation of organic quinolones from the antibacterial class. It extends to revisions that request a bias review. Until that could be done, all safety/SAE text was gathered under preexisting headings. Otherwise:

(1) The article needs to be retitiled, and/or split into two articles, where the organic structural class of quinolones is disambiguated from the antibacterial class which has taken its name (and which was earlier the sole emphasis of this article).

(2) It appears that at least one major contributing author/editor simply doesn't much like the overarching quinolone class of antibacterials: count the number of positive lines and compare that to the number of negative lines. And where is it pointed out in relation to safety testing, that relative to chronic drugs such as the statins, an antibacterial of any given class/type is rarely given in any regimen approaching chronic?

Problems acknowledged, quinolones still save lives, and are not themselves (as inanimate, bioactive agents) responsible for their misuse by physicians. If one wants the drug to be reliably used, you must simply tell the truth about it, not try to counterbalance misuses and shortcomings through imbalanced treatment.

Until a careful and balanced consolidating edit can be done, I gathered all safety study and serious adverse event (SAE) information from its various distributed earlier locations, putting it together under headings already created by other authors. Only most offendingly inaccurate statements were actually removed or strongly edited.

(3) Note, Trova and other NAPHTHYRIDINES need to be called out as structurally distinct antibacterial class, that is NOT, formally indicated as quinolones. Encyclopedias should not be intellectually sloppier than the (often admittedly weak) primary literature, but more careful, because its audiences are less informed.

Bottom line, much more work is needed to make this a balanced, first-class article. Prof D — Preceding unsigned comment added by Meduban (talk • contribs) 01:43, 14 April 2011 (UTC)

Dead link
During several automated bot runs the following external link was found to be unavailable. Please check if the link is in fact down and fix or remove it in that case!


 * http://www.sfgate.com/cgi-bin/article.cgi?file=/news/archive/2006/05/01/national/w120748D88.DTL&type=health
 * In Gatifloxacin on 2011-03-19 19:15:03, 404 Not Found
 * In 2- and 4-Quinolones on 2011-05-25 06:55:58, 404 Not Found
 * In 2- and 4-Quinolones on 2011-06-10 04:44:59, 404 Not Found

--JeffGBot (talk) 04:45, 10 June 2011 (UTC)

Dead link 2
During several automated bot runs the following external link was found to be unavailable. Please check if the link is in fact down and fix or remove it in that case!


 * http://www.fda.gov/cder/drug/InfoSheets/HCP/fluoroquinolonesHCP.htm
 * In 2- and 4-Quinolones on 2011-05-25 06:55:58, 404 Not Found
 * In 2- and 4-Quinolones on 2011-06-10 04:45:09, 404 Not Found

--JeffGBot (talk) 04:45, 10 June 2011 (UTC)

Dead link 3
During several automated bot runs the following external link was found to be unavailable. Please check if the link is in fact down and fix or remove it in that case!


 * http://fpnotebook.com/ID160.htm
 * In 2- and 4-Quinolones on 2011-05-25 06:56:04, 404 Not Found
 * In 2- and 4-Quinolones on 2011-06-10 04:45:17, 404 Not Found

--JeffGBot (talk) 04:45, 10 June 2011 (UTC)

Various suggestions
Maybe I am missing something, but several of the drugs are not Quinolones. Also it would be a good idea to split into 2- and 4-ones. --Smokefoot (talk) 20:28, 22 July 2017 (UTC)

Recent BMJ study - Fluoroquinolnes are associated with increased risk of aortic aneurysm and dissection https://www.bmj.com/content/360/bmj.k678?fbclid=IwAR1zobZ7CJ8gqK_xZJJwLB1Ghvzf_vcoifSVR4iNKfbhkDckuZE18b2hNfc  — Preceding unsigned comment added by 87.115.71.35 (talk) 16:14, 21 December 2018 (UTC)

How is 8-hydroxyquinolone sulfate related? Active ingredient in Bag Balm since 1899? Dphilli55 (talk) 00:10, 2 February 2019 (UTC)

Merger proposal
I propose that Fluoroquinolone-associated_disability be merged into Quinolone_antibiotic. A Google search shows up sufficient mentions to warrant this. In particular, see https://www.researchgate.net/publication/320027629_Treatment_of_the_Fluoroquinolone-Associated_Disability_The_Pathobiochemical_Implications. 114.77.12.93 (talk) 23:40, 11 January 2018 (UTC)
 * Agreed, for different reasons. With (only after?) cleanup this will be a notable, but short, section. - B.S. Lawrence (talk) 23:32, 1 May 2018 (UTC)
 * {[done}} it was already discussed here. Links here and there were dead.  I am updating the links here and will flesh out a bit more with good refs. Jytdog (talk) 21:01, 5 May 2018 (UTC)

Floxing - "being floxed" = Fluoroquinolone-associated disability (FQAD)
" Floxing - "being floxed" = Fluoroquinolone-associated disability (FQAD) - is an adverse reaction to a class of commonly prescribed antibiotics called fluoroquinolones; common symptoms are tendonitis, severe fatigue, neuropathies, and shooting pain. Fluoroquinolone-associated disability (FQAD) is sometimes referred to as “being floxed.” The FDA found that FQAD symptoms can appear within hours to weeks of taking a fluoroquinolone. Side effects lasted 14 months, on average. But, some people reported symptoms lasting 9 years. "

Got this from a google search. Anybody with more knowledge to insert this? Sorry no more time, SvenAERTS (talk) 23:39, 29 August 2023 (UTC)


 * I’m not surprised that this article doesn’t mention getting ‘Floxed.’ Very few wikipaedia articles ever mention iatrogenic diseases and disorders. A good example of this is how the article on SSRIs do not mention Post-SSRI Sexual Dysfunction (PSSD), a quite similar, drug-induced condition.
 * I’m rather surprised what you found by the FDA concludes that most people who get ‘Floxed’ recover from it within 14 months. I was under the impression that FQAD is something that generally lasts years and is potentially of lifelong duration (I do not like to use the word ‘permanent’).
 * ‘Long Covid’ (aka Post-Covid Syndrome) and CFS/ME are two additional conditions which appear to be related to FQAD. 71.25.29.66 (talk) 17:32, 3 October 2023 (UTC)