Talk:Rebound effect

Valproate
The anti-epileptic drug valproate also has a rebound effect. When reducing the dose after taking it for months or years, he is especially sensitive getting seizures. — Preceding unsigned comment added by 85.180.189.119 (talk) 21:50, 26 February 2014 (UTC)

Rebound Anxiety (header previously, "Apparent Error")
"Approximately 70% of patients who discontinue a benzodiazepine experience a rebound effect.[2]"

Unfortunately, ref. 2 is not about benzodiazapines, as they are common defined. Dehughes (talk) 20:45, 3 August 2011 (UTC) Removal of Section Notice I have removed entirely the section 'Rebound Anxiety'. The reason for this was my light and incomplete reading of the second reference. I was interested in rebound anxiety, and yet all three references in this section were in regard to studies of rebound insomnia in insomniacs. The second reference, as Dehughes (above) noted, is not studying benzodiazepines at all. It studies Zolpidem and Zopiclone (neither of which are benzodiazepines). The apparent error, noted by Dehughes (above) is corroborated in my reading of the referenced study. In direct quotation of the source for the mentioned sentence, "Surveys of hypnotic use among the elderly have reported rates ranging from 12% to 25%, the most commonly used hypnotics being benzodiazepines, most often of the short-acting type. Short-acting benzodiazepines are generally less likely to have residual daytime effects than long-acting benzodiazepines, but may be associated with rebound insomnia, tolerance and amnesia. In a clinical trial in Japan investigating exacerbation of symptoms following benzodiazepine discontinuation, this was observed in 70% of the patients." As we can read above, the study is on the relative efficacy of non-benzodiazepine drugs on primary insomnia. The referenced clinical trial (where the seventy percent figure is obtained from) is from this (see my ref. 1) paper. Again in regards to insomnia. Since all three references were in regards to rebound insomnia, rather than rebound anxiety, the section has been removed. Lumpy Berserk (talk) 04:14, 26 September 2017 (UTC)

rebound insomnia
I don't have this source, so I can't officially contest the material, but I have an issue with this sentence:


 * Regular use of these substances can cause a person to become dependent on its effects in order to fall asleep through the process of classical conditioning.

To my knowledge, that isn't an example of classical conditioning. Classical conditioning can be used for unconscious behaviors, but it is typically used in the context of conscious ones. This sentence makes a false equivocation. When someone uses a sedative and has an easier time falling asleep, they will learn to take more of it (assuming they enjoy that effect). This certainly is classical conditioning, but what they are learning is to take the drug, not "...to fall asleep..." One cannot really learn "...to fall asleep..." through classical conditioning. And they certainly can't through "regular use of these substances." The sentence technically, syntactically, does not make sense. From taking these substances, you don't learn to fall asleep, you learn to take the drug. Falling asleep cannot be learned from simply taking a drug. Charles35 (talk) 04:27, 19 November 2012 (UTC)
 * Be WP:BOLD and delete the sentence. :)-- MrADHD  |  T@1k?  11:38, 19 November 2012 (UTC)

This article does not mention cough medicines and similar preparations. — Preceding unsigned comment added by 101.160.201.70 (talk) 01:18, 10 October 2013 (UTC)

Should be separate page/article for GABAergic rebound
Although virtually all drugs can cause normal withdrawal, mostly only GABAergic substances (with a few exceptions) cause a true “rebound effect” which is immediate, but mild short-term dependence in a sense that results from literally the exact same mechanisms as ‘normal’ withdrawal syndrome from extended usage. Negative symptoms after things like short term use of stimulants; is merely due to related mechanism but not the same mechanisms. Rebound is quite literally; essentially low level withdrawal. Stimulant crashes/hangovers/negative symptoms from short term use are absolutely not, and as far as at least recreational drugs go; only GABAergics such as benzodiazepines, alcohol, etc. elicit a true genuine rebound withdrawal phenomenon. They should at least have a separate page because treating all or most drug crashes/after-effects as being the same thing as the infamous “rebound effect” is pure pseudoscience and a misnomer at best. Dexedream (talk) 22:19, 15 May 2023 (UTC)