Talk:Receptor (biochemistry)

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 2 February 2021 and 14 May 2021. Further details are available on the course page. Student editor(s): Dmk1106.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 07:52, 17 January 2022 (UTC)

Untitled
Hmmm... How come this page about Receptors is under 'Proteomics' ? How about 'Cell Biology' or 'Pharmacology' ? - PFHLai 14:11, 2004 May 18 (UTC)

I concur. Although receptors are mainly proteins, not all are. This article should be moved and edited to correct this. - Centrx 21:59, 19 May 2004 (UTC)

Revision: I don't know much about biology, so I don't know if all neuronal/tissue receptors are proteins. However, this article conflates both these kind of receptors, which recognize neurotransmitters, hormones, etc., and immune receptors, which are on a region of antibody molecules and recognize antigens. The latter kind are not proteins.

Conclusion: 1) Properly, the latter kind should not be discussed in this article. 2) If it is not true that all receptors of the former kind are proteins, this article should be renamed and edited to correct this. - Centrx 22:30, 19 May 2004 (UTC)

"Many genetic disorders involve hereditary defects in receptor genes..." why the heck is this the first paragraph in the overview? i'm making into its own section. Amutepiggy 22:56, 26 January 2006 (UTC)

Cognate
The word cognate is often used in conjunction with receptors and ligands; the word should appear in this article and be defined. — Preceding unsigned comment added by Tedtoal (talk • contribs) 17:57, 19 April 2018 (UTC)

electroreceptors
I was surprised to be redirected from a page on the electroreceptors in the platypus bill to this page. Aren't we talking about two different things here, or am I mistaken?Adambrowne666

fixed - hope no one minds Adambrowne666

sympathetic receptors
What is a sympathetic receptors? --Abdull 16:45, 27 April 2006 (UTC)


 * A receptor in the sympathetic nervous system ? --PFHLai 02:18, 3 September 2006 (UTC)


 * If some receptors are functionally interdependent they might be called sympathetic receptors --Fuelbottle 13:05, 3 September 2006 (UTC)

Nuclear Receptors and Transcription Factors
The writers need to include NUCLEAR RECEPTORS... include a description and link to the Wikipedia article on Nuclear Receptors.

Also, the section on Transcription Factor needs to be changed... while it is true that the various steroidal nuclear receptors are technically transcription factors, this is conceptually upside down. The BASIC CONCEPT is that steroidal hormones fit the classic Ligand-Receptor interaction model. They should be described as nuclear receptors first, and transcription factors second.

changing disambiguation structure?
If you look at receptor, it has many incoming links, almost all meant for this article. I propose this article is moved to receptor, and the disambiguation page moved to receptor (disambiguation), with a link to that placed at the top of (the new) receptor. ssepp(talk) 21:24, 18 May 2007 (UTC)

Toll-like receptors ?
Could these be added to the appropriate section (whatever that is) Rod57 10:12, 12 September 2007 (UTC)


 * Some TLR (eg TLR4, but maybe not TLR3) seem to be transmembrane proteins but may also belong to other of the categories listed here ? Rod57 10:26, 12 September 2007 (UTC)

How can receptors enter the nucleous?

two senses of receptor
I think the term receptor refers to two separate concepts in biochemistry and these should be covered in separate articles to avoid confusion. This distinction should be made in the disambiguation page for receptor and two separate articles should cover these topics broadly. --InfoCan (talk) 18:09, 1 October 2008 (UTC)
 * 1) signal transduction receptor is a protein involved in converting an extracellular signal to an intracellular signal.  The extracellular signal can be a molecule (neurotransmitter, hormone, antigen, etc.) or a physical stimuli (light, electric field, physical deformation due to touch, sound, etc.). The signal can be relayed in terms of opening a channel, activating a kinase, binding to DNA, etc. So this category includes neurotransmitter receptors, nuclear hormone receptors, photoreceptors, etc.
 * 2) attachment receptor is a molecule (not necessarily a protein) that enables specific binding of a ligand to a cell. Examples would be viral receptors (e.g. the lamB porin for lambda phage or CD4 for HIV), endocytic receptors (eg. LDL receptor for LDL, sialic acid for influenza virus and ganglioside GM1 for cholera toxin), and cell adhesion receptors (N-CAM for nerve cells binding each other, adhesins receptors mediating binding of bacteria to epithelial cells).

Kd and its reaction as shown is wrong
The equation L.R <--> LR is wrong.

It should be

L + R <--> LR

In other words, the sign should be + not "."

And the constant corresponds to Ka, not to Kd (the reaction as it is shown correspond to an association, not to a dissociation).

The reverse equation corresponds to Kd and Ka = 1/Kd —Preceding unsigned comment added by 200.16.86.36 (talk) 13:56, 19 October 2009 (UTC)

Plain English at top
I've added a couple of sentences at the top of the page in plain English, in response to the request to de-jargon it. Hope that's OK KatArney (talk) 12:57, 4 May 2011 (UTC)
 * More than OK, an improvement! Thanks! --Tryptofish (talk) 20:09, 4 May 2011 (UTC)

Receptor Regulation
The section on receptor desensitization, under Receptor Regulation, has two bullet points:
 * Uncoupling of receptor effector molecules.
 * Receptor sequestration (internalization).

These need to be explained or linked to explanatory pages. Also it would be helpful to know how these relate to Receptor Regulation. Based on a quick google search, I'm guessing they may refer to two types of desensitization (I only saw these mentioned in an article about one type of receptor and the passage referring to the two mechanisms was unclear about weather or not this information was specific to the receptor discussed in the article.) Anyway, if someone has access to the book cited with these bullet points or knows of another source that generally explains what they mean and how they relate to receptor regulation, it would be great if they could elaborate here. — --Xttina.Garnet (talk) 11:18, 10 June 2011 (UTC)
 * Yes, that's a good point. I've tried to fix it, at least to the point of providing internal links. Does that help? --Tryptofish (talk) 19:02, 10 June 2011 (UTC)

Assessment comment
Substituted at 04:01, 30 April 2016 (UTC)

various problems
Structure - Type 2 - The binding-site for larger peptide ligands is usually located - Delete -

Type 3 - often with enzymatic-function - Delete -

Binding and activation - (e.g. second messenger cascade, muscle-contraction) - Delete -

Efficacy is the measure of ? the bound ligand to activate its receptor (try the ability of)

Receptor-regulation - Delete -

Cells can increase (upregulate) or decrease (downregulate) the number of receptors to a given hormone or neurotransmitter to alter their sensitivity to different molecule? (add s, and shouldn't "to a given hormone or neurotransmitter" just be "for a given ligand"?)

This is a locally acting feedback mechanism - Change "is" to "can be" and add - between locally & acting

is seen with G-protein couple receptor - Should be G protein-coupled receptors.

(internalization). - Change. to ,

Examples and ligands - Ion channels and G protein coupled receptors - Add - after protein

(specifically, GPCRs) - Delete s before )

Table - G protein coupled receptor - Add - after protein

GABA & Glycine - HCO-3 - Change to HCO3-

Serotonin - 5-HT1-2 or 4-7 - Shouldn't the numbers be subscripts?

Enzyme linked receptors - Add - after Enzyme

as in bone morphogenetic protein and guanylate cyclase - Add receptor, after protein

Intracellular receptors - 4 examples of intracellular LGIC are shown below - Add s after LGIC

In the immune system - killer activated - Change activated to activation

Ref. 4 - Both drugs are agonists are? nicotinic cholinergic receptors

Ref.13 - angiotensin II receptor of bovinde? 71.163.180.156 (talk) 06:31, 14 October 2020 (UTC)