Talk:Reverse tolerance

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"...or in some cases an additional increase of effects with continued use of a single drug existing alongside or not to a tolerance for other aspects of the same substance.."

or not... what? I can't figure out what this is trying to say but I'm pretty sure it doesn't make sense. —Preceding unsigned comment added by 63.192.212.28 (talk) 00:33, 11 March 2010 (UTC)

(@above) Makes perfect sense, though it could definitely be worded more clearly. It's saying that it's possible for an individual to become more sensitive (ie less tolerant) to CERTAIN EFFECTS of the drug, while simultaneously developing a reduced sensitivity (more tolerant) to other effects of the same drug, at the same time of administration. Basically it's saying it's not black or white, that you can't say "drugs effectiveness is reduced by 50%" because often the overall effect of tolerance to the drug is all over the place.

There is a lot more information to be put down on this page, I'll see what I can come back and do later on (busy atm), but information on this topic was invaluable to me when taking Adderall for ADHD — Preceding unsigned comment added by 130.215.237.64 (talk) 20:50, 1 February 2012 (UTC)

(reply @above) Okay, I get it... at least, I get what you wrote. Sadly I still don't understand why the "or not" has to be there, parentheses or no :) ...if we're trying to clear up a false dichotomy why not talk about exactly what you said, something along the lines of different effects of the drug changing (whether increasing or decreasing in subjective strength), independently over time... maybe you or some other wikier could replace that section with your explanation from here in the talk?
 * I can't parse it either, and it's fair to say that something that could "definitely" be worded "more" clearly does not make "perfect" sense. JohndanR (talk) 03:23, 21 March 2022 (UTC)

—Preceding unsigned comment added by 63.192.212.28 (talk) 00:33, 25 January 2013 (UTC)

Rewrote article
I have re-written the article based on the Drug tolerance page, as the current version was hard to understand and partially inconsistent with how other pages (and external sources) define reverse tolerance/drug sensitization. The article would still need to be developed more, as right now it is more a symmetry of the drug tolerance page than a real article, but I do not have sufficient expertise to do this. 7804j (talk) 16:29, 17 May 2017 (UTC)

Mechanism
Yes and no. For example, sensitization to the effects of alcohol also occurs on a short-term scale, having much more to due with changes in gene expression and receptor remodeling in areas of the brain governing reward and motivation than metabolic parameters. This is a fairly recently uncovered phenomenon, with little information about it existing about it outside of scientific journals. A website about harm reduction that gives no citations of its own and could've been made up by anybody should not be considered a reliable source.