Talk:Rexed laminae

Dorsal horn circuitry
The dorsal horn is not a simple relay station, but a site of significantly complex signal processing. The majority of neurones in laminae-I-III are excititatory or inhibitory interneurones. There are a large number of different circuit motifs that have been found to involve specific types of dorsal horn interneurone, and functions involved in signal processing have been inferred from this. Glycinergic neurones compose about 90% of the inhibitory interneurone in deeper layers of the dorsal horn, whereas they only make up 20% of the inhibitory neurone population in laminae I & II. Parvalbumin-countaining neurones in lamina II, which utilise glycine, have been found to receive input from primary sensory afferents and provide presynaptic input to these terminals, allowing feedforward inhibition and winner-take-all computation. It has been suggested that they play a role in both the refinement information relating to tactile touch, and gating of tactile information being processed as pain in conditions such as allodynia. B5-I interneurones play an important role in the processing of itch sensation, and can suppress itch through the action of dynorphin on delta opioid receptors, or cause fast relief from itch through the presence of competing somatosensory stimulation, for example scratching.
 * Moved this info from page - more relevant to posterior grey column and the refs to laminae are related to mice and rat studies.--Iztwoz (talk) 11:35, 2 June 2018 (UTC)