Talk:Ribonucleotide reductase

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Jhalaby.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 08:09, 17 January 2022 (UTC)

Cystein
Thanks for the nice graph of the ribos reduction. But actually it's a Cystein, which is the radical amino acid (Cys439 in E.Coli numbering), not a Tyrosin. The Tyrosin (Tyr122) only 'stores' the radical in R2. 131.152.112.110 10:48, 23 January 2006 (UTC)

peer review
I posted this in the peer review section, but since it's been a while since the request, I thought it might get buried. I may just end up making a few changes in a couple of days, but I wanted to make sure the original authors saw the commentary:

Holy text blocks, Batman! I wouldn't normally say an encyclopedia article has too much information, but... this has way too much information. It really looks like you just copied your thesis intro chapter wholesale, which makes it good scholarship but confusing to a general audience. Solidly referenced for the most part, but in need of significant rewriting to make it accessible to non-experts (and why would an expert be looking it up on Wikipedia?) Specifically:
 * There are no wikilinks after the lead. Not everyone reading this article will know off the top of their heads what a disulfide bond is, or what NADPH looks like, etc.
 * There's a ton of jargon. Again, non-experts don't know that dNTP = deoxyribonucleotide, and don't appreciate the dNTP/NTP distinction.
 * The illustrations are too large and rather difficult to follow. The captions are awkwardly formatted and very long. At one point it looks like there was an image depicting the reaction pathway in this article - was it removed for copyright reasons or just left by the wayside? In any case, it or something like it should come back.
 * There's entirely too much detail in text about the structure, and no picture of the protein! It looks like the PDB has a wide variety of structures to choose from, though I don't see a structure of the complex.
 * Minor bits of unnecessary detail like the residue number of the reactive tyrosine in different species should go. Same with the residue numbers of the electron transfer pathway.
 * Consider converting the references to a footnote style. Parenthetical citations just make already long text blocks look longer.

Lastly, a content question - I don't believe RNR is the only enzyme that uses a radical-dependent mechanism. Cytochrome c oxidase and chlorophyllide a oxygenase come to mind, I'm sure there are others. Azileretsis (talk) 14:59, 18 November 2011 (UTC)Opabinia regalis 02:55, 28 May 2006 (UTC)

Kudos for whoever wrote the Metabolic pathways section. Azileretsis (talk) 14:59, 18 November 2011 (UTC)

I feel that the entire "Metabolic Pathways" section doesn't belong. It's tediously long and dense and it barely addresses RDR itself. It might be an effort to put RDR in a larger context but it falls on its face. The page won't be missing anything if it's removed. Higgyrun3 (talk) 03:29, 9 December 2012 (UTC)