Talk:Risperidone/Archive 1

Off label use of atypical antipsychotics for major depression.
The article states "like most atypical antipsychotics, Risperidone is used off-label for treatment of major depression." This is an over-generalization. Today, many psychiatrists in America hesitate to use atypical antipsychotics for major depression, limiting their off-label use for bipolar depression, not unipolar. Recently the makers of Abilify (apriprazole) began marketing their drug for treatment of major depression and the medical community has shown resistance, feeling that there are more tried and true methods to treating major (unipolar) depression. —Preceding unsigned comment added by 63.197.31.136 (talk) 16:17, 11 April 2009 (UTC)

How it'll probably make you feel and why?
Risperidone is a very strong dopamine blocker (antagonist) that is to say it inhibits functioning of dopamine receptors. It reaches peak plasma levels quickly regardless of wheter it is administered as a liquid or pills. The strong dopamine-blocking reaction is known to make some people feel nauseous if you do anything that normally triggers the dopamine reward, such as eat a good meal or have sex. Risperidone is metabolised fairly quickly so this potential for nauseation subsides usually in two to three hours.


 * This will not happen in every case, and if these side effects do occur in an individual they can just as easily be produced by any other anti-psychotic as they are all dopamine blockers! I am quite familiar with this medication as I take it, the only undesireable side effects it has ever produced for me are muscle stiffness/pain and weight gain. Both of which can easily be handled (stiffness by reducing the dose and weight gain by watching the things one eats more carefully). -- RTC 08:11 Apr 10, 2003 (UTC)


 * Dopamine blockers are generally ANTI-nausea drugs. They are specifically used that way, for example prochlorperazine, droperidol in small doses. I suppose some people might be made nauseous by risperidone, but then some people might get a headache if they take aspirin. As for the sexual side-effects, these are more common: lowered libido and inability to have an orgasm. -spgrk, 20 June 06.


 * If you want to include this comment someplace, put it in the article on antipsychotics, not here. -- RTC 23:11 Apr 14, 2003 (UTC)


 * I concur to this. Most the side effects I experienced with Risperidone passed after the first to days of taking it. I am however interested (and cannot find anything) in the side effects that occur when going off the drug. I have decided to go off the medication and these withdrawl symptoms are of my curiousity. I however cannot find anything on the subject.
 * Ive tried Risperdal for a week and had to quit because of side effects. Withdrawel symptomes of Antipsychotics arent well known because almost all of the time, they switch to a different drug. Although Autistic people against neuroleptics has some withdrawel information. --Moop stick 22:58, 23 January 2006 (UTC)

But this _is_ specific to Risperidone, since it has such a fast attack and it's such a strong dopamine blocker. Sure if you start with 0,5mg and after a week go to 1mg and after a week go to 2mg, which is the clinical dosage in these parts of the world at least, your neural nets will get adjusted as you go along.

If you think dopamine blockers are essential for your well being you should consult your phycician about getting on Olanzapine (expensive but works really nicely for most ppl) or if you're feeling suicidal or otherwise totally chaotic then Clozapine might work well. Also might want to consider googleing for "DHA fatty acids and scitthhzophreniernia or whatever the whitecoats diagnosed you with this time" There is propably something on this combo in the Lancet archive, but I'm too busy to dig it up now. Fatty fishes contain a good dosage of DHA. Happy healing. Tzuhou 10:45 Apr 15, 2003 (UTC)


 * I have Bipolar disorder and take Depakote and Risperdal. I am hyper-sensitive to most antipsychotics and actually had to reduce my dosage of Risperdal from 1mg to 1/3mg (I went completely stiff and had severe pain at the slightest movement at 1mg. Even 1/2mg causes stiffness and pain after a couple days). When they tried Stelazine once I had bad akathisia at all dosages they tried. One 2mg tablet of Trilaphon was all I could tolerate. The Risperdal works very well, and I like the side effect of more dreaming that I get from it.
 * I made a few wording changes and a spelling correction. I'll leave it the way it is for now... -- RTC 23:32 Apr 15, 2003 (UTC)

Thanks for the edits, it's much better now. I'm totally schitzo. I've been through DSM-IV-TR (though ICD is the authority in this part of the world) playing white and black coat at the same time and I have to say that I've found numerous combinations to diagnose myself schitzo without even lying as playing white ;) but hey, that's life. Last time I was in the loonie bin they put me on valproic acid too, but I didn't like it much. It made me really apathic. Perphenazine is fun: you never know what is it this time, if you know what I mean ;) I used to play chess with this old guy that went to the ward once a month to get a 1mg injection of perphenazine. It's an amazing pharmaceutical *grin*. I take 16mg nowerdays and it actually works :) --Tzuhou 00:06 Apr 16, 2003 (UTC)


 * I'm not completely satisfied with the article, but it no longer says the things that bothered me most. I'll let others nitpick it more if they want to.
 * Fortunately for me, the valproic acid was the first mood stabilizer they tried on me, and it started working within the first week (I take 1500mg of it). Anything over 2mg of perphenazine however gave me akathisia almost as bad as the Stelazine did, but it worked OK for the about 5 years that I took it... however it seems to have given me a bit of Tardive dyskinesia (which showed up in the first few weeks after switching from it to Risperdal)
 * Hope things work out... -- RTC 00:22 Apr 16, 2003 (UTC)


 * Yup. Valproic acid is good for cutting off the worst (or best, depends on how you look at it) mania.


 * Well, it was a severe Manic psychosis and needed to be cut off quick! -- RTC 01:57 Apr 16, 2003 (UTC)

BTW, I looked up Olanzapine and it is a dopamine blocker (as well as a blocker of several other neurotransmitters). -- RTC 00:37 Apr 16, 2003 (UTC)


 * Sure, but it's much more mellow. Levels in plasma stay pretty constant due to slow biological absorbation (even as velotab, which is amazing, because it dissolves in a second when you put it in your mouth) and slow exit. I think it blocks serotonin too, though I'm not sure.


 * Right, serotonin and several others. -- RTC 01:57 Apr 16, 2003 (UTC)


 * I just remembered that Olanzapine has this fairly unique property that the parts of human brain that are most dopamine ruled are really good at compensating for the blocking reaction of the drug. This is researched info.


 * Do know of some good online pharmacology catalog that's freely accessible? akathisia? what's that?


 * Akathisia usually manifests as a total inability to sit still. The person is always pacing. If forced to stay still usually the person gets very nervous and anxious. I sure did. One guy I know got it so bad once that he smashed a hole in the wall with his head before they realized what was happening and gave him a large dose of Benaydrl as an antidote. -- RTC 01:57 Apr 16, 2003 (UTC)


 * Maybe you should write an article on Akathisia?


 * OK, done. -- RTC 03:02 Apr 16, 2003 (UTC)


 * I once talked with this girl who is a dementia nurse and she told me that no elderly patients ever get risperidone, which is good to hear. Subjectively I think that the drug a form of neurochemical violence.


 * They have to be careful with any antipsychotic and the elderly. -- RTC 03:02 Apr 16, 2003 (UTC)

I work with children with autism and some of them are prescribed risperidone. One particular child has STOPPED taking risperidone for around 3 months now. While on the drug he was happy and cheerful talked to staff alot and was very active. 3 months after stopping he has problems initiating movements and gets stuck in the middle of actions like getting dressed or stepping on to the pavement. Could this be a side effect of the risperidone or a side effect of its cessation? He is also far more fixated on certain songs or topics of conversation with respect to when he was on the drug. —Preceding unsigned comment added by 83.98.0.10 (talk) 11:28, 9 October 2007 (UTC)


 * what was the dosage? How long did the child take it for? I don't know the answer to your question but my 8 year old son just started taking Risperdol today (.25mg). He does not seem autistic to me but he has been having trouble at school. Sometimes he gets agressive and hits out at the teacher or other students. We want to take it for the minimum amount of time and get him off ASAP. Right now we are watching to see how it affects him and if it helps. I appreciate any comments or input on other people's experience with Risperdol and children!

Thanks,

Gregorio-Smith (talk) 18:56, 13 May 2008 (UTC)
 * I took risperdal for 2 months and stopped because of a weight gain of 9 lbs, a sudden increase in appetite, and very poor concentration. I also lost the ability to feel pleasure and felt flat/blunted. i still feel this way after being off it for several months. Can this drug cause permanent damage? — Preceding unsigned comment added by 169.244.148.235 (talk) 22:33, 16 August 2011 (UTC)

Generic?
Does anyone have access to information as to why there's no generic form of Risperdal sold? The stuff costs almost $500/mo for 4mg/day over 30 days.

There are no Risperdal generics available yet. As the patent for Risperidone is still in place. You could try getting the pills from your psych's office every month, since Risperdal does have sample boxes that last a month. Or you could get Risperdal available by injection, which lasts a long time. --Moop stick 21:23, 22 January 2006 (UTC)

Risperdone is a generic for risperdal. Kazuba (talk) 17:50, 16 September 2015 (UTC)

Possible POV
I have OCD and Asperger's, so I may be reading to much into this, but in referring to the Risperdal Conste, mentioning that it is vital given the large number of people with schizophrenia who are unwilling or unable to take their medicine, one may be applying the value judgement that schizophrenics and people with mental illnesses must take drugs. I certainly don't want schizophrenics to be hurt as a result of their schizophrenia, but injecting drugs that f*ck with a person's brain is a fairly serious action. I am not trying to editorialize, but there are plenty opposed to forced medication. More than likely I am reading a message that isn't there, and given the fact that I take Risperdal I do harbor some resentment towards it and many drugs in general, but I eagerly await your response. Thank you.

Iain Marcuson Imarcuso at Wikibooks.


 * I'm somewhat puzzled, if the FDA says Risperidone is not approvable for autisim, why is it prescribed? I also think there is something wrong-sounding about the Consta statement.  You can rewrite it if you want or propose a new version here.  It would be good to have a source for any statement that Consta is "vital" for some reason for any class of patients. Thatcher131


 * ANSWER TO THATCHER131'S QUESTION: Most pharm. companies only spend the money on getting their drug FDA approved for one or two indications. That doesn't mean that those drugs don't help conditions outside of the FDA approval, and when they're prescribed for purposes not explicitly approved by the FDA, it's referred to as "off-label use."  —Preceding unsigned comment added by 63.197.31.136 (talk) 16:23, 11 April 2009 (UTC)

--Moop stick 01:33, 7 May 2006 (UTC)
 * Actually people with schizophrenia will forget to take their meds. According to the Risperdal Consta instructions, doctors must give patients Risperdal is tablet form to see if they can tolerate it. Then if they can, they can get the injection, but must continue to take Risperdal in tablet form until the injection starts working. Once it works, they'll be symptome free. Many people are willing to take their meds, but there are many things that can get in their way to prevent them to. Risperidone is a very strong tranqulizer. It's mainly used to treat behavior problems in autistic children because it is considerably very powerful in controlling behavior problems compared to other antipsychotics.
 * How often are the injections given, and who gives them to the patient? Thatcher131 01:40, 7 May 2006 (UTC)
 * Every two weeks, and the patients psychiatrist gives them the injection. --Moop stick 17:29, 7 May 2006 (UTC)
 * Maybe people with schizophrenia "forget" to take their meds because of the distinctly nasty side-effects of the meds prescribed for them. 118.209.63.205 (talk) 09:38, 18 February 2012 (UTC)

Correlation with Tumors
What's wrong with the link to the Duke university webpage? I mean, the scientific citation is best, but I think it's also helpful to have a link to a more non-technical summary.

Further, what's wrong with clearly saying in the "side effects" section "Risperdal is correlated with pituitary tumors." You kind of buried that detail in another section, whereas I think that's a pretty big deal.

—The preceding unsigned comment was added by Fsk (talk • contribs) 03:12, 4 June 2006.

I've updated the tumor stuff, with DukeMedNews as a Reference, not an External link. Colin°Talk 11:01, 4 June 2006 (UTC)

Trust me, I've had some prolactin troubles with Risperdal. It's not life threatening, and not signifigant enough to be put under as a safety risk. It's also been addressed in the "side effects" area. I also like this WebMD article better. But I'll leave the issue up to someone else. --Moop stick 03:32, 4 June 2006 (UTC)

I was trying to track the debates regarding the claims of increased stroke risk in older patients with dementia. Wasn't this a significant side effect claim that led to prescription advice altering in a number of juristictions? —Preceding unsigned comment added by 82.153.251.65 (talk) 10:26, 16 April 2009 (UTC)

Paliperidone
You've really confused me now, Moop Stick. Why did you take off those two links just now? —The preceding unsigned comment was added by Fsk (talk • contribs) 03:52, 4 June 2006.

The ones about Paliperidone? Because, Paliperidone isnt really related to Risperidone. Theyre just owned by the same company. Talk about Paliperidone shouldnt belong on this article. —The preceding unsigned comment was added by Moop stick (talk • contribs) 04:51, 4 June 2006.

How did you know that Paliperidone isn't really related to Risperidone? —The preceding unsigned comment was added by Fsk (talk • contribs) 05:08, 4 June 2006.

Paliperidone is the major active metabolite of risperidone, it is only differentiated from risperidone by the addition of one hydroxy group. Colin°Talk 11:01, 4 June 2006 (UTC)

Preferably the tumor information should link to the actual scientific article.
 * Szarfman A, Tonning JM, Levine JG, Doraiswamy PM. Atypical antipsychotics and pituitary tumors: a pharmacovigilance study. Pharmacotherapy. 2006 Jun;26(6):748-58.
 * Newspaper articles, whether written by science reporters or university press officies, frequently misstate the results of scientific studies. I've been following the changes here but haven't jumped in because I haven't had a chance to read the actual article (maybe Monday).  I'd like to see what it really says and not what the Duke public relations office says it says.

Also regarding paliperidone, it is simply a slightly more active form of risperidone and should probably be kept here, not as its own article, since Risperdal and the other brand names don't have separate articles. If, for example, paliperidone turns out to have significantly fewer side-effects, it might later deserve a separate article, but for now its not even on the market. Thatcher131 12:15, 4 June 2006 (UTC)


 * Er, it does link to that paper. Paliperidone is a different drug, albeit very slightly. Colin°Talk 20:19, 4 June 2006 (UTC)

Stopping Risperidone
Can anyone tell me how long Risperidone stays in your system after you stop taking it?


 * The answer to your question is found in the box at the top of the page where it says "half life." Half the drug is out of your system within three to twenty hours.  Half of the remaining drug will clear during the next three to twenty hours, and so forth.  The usual rule of thumb is that ten times that means you're clear of a drug. WhatamIdoing 17:46, 25 September 2007 (UTC)

Just wanted to add that you also have to taper off the dosing of the medication. The doctors warn that if you suddenly stop taking it, it can have very unwelcoming side effects much like those of drug rehab patients. 16:03, 22 April 2008 (UTC) —Preceding unsigned comment added by 24.113.101.242 (talk)

On 70.54.52.226's edits
His some of his edits might be useful, but he put it too prominently to the level that it would not be NPOV IMO. I would change the way he represented this; opinions are welcome. -- Sa mue l C urt is -- TALK  16:46, 1 November 2006 (UTC)


 * He's a through anti-psychiatrist and I have throughly toned down his edits. I still keep FDA's warning about hyperglycemia, though.-- Sa mue l C urt is -- TALK  17:07, 1 November 2006 (UTC)

My advice to anti-psychiatrists
If you want to argue on your cause, please go on doing that on Schizophrenia. Any unproved statements in this article should be promptly removed per WP:VANDAL and to be reported to the admin as such.

Why should anti-psychiatrical arguments be taken to Schizophrenia? —Preceding unsigned comment added by 172.143.68.173 (talk) 21:36, 14 December 2007 (UTC)

I agree mental disorders may be a cultural phenomenon and mental medications is a part of it, but this, any other mental medication articles, are not appropriate to discuss the merits of psychiatry. -- Sa mue l C urt is -- TALK  17:30, 11 November 2006 (UTC)

Please upload all the images to the Commons
I'm planning to improve the Russian version of the article, and images would help. (0: Best regards, CopperKettle 10:48, 10 March 2007 (UTC)
 * Here's the structural formula. Image:Risperdal tablets.jpg is already in Commons, but I'm afraid the logo is fair use, and so can't be on Commons. The copyright of Image:Risperidone-icon.jpg also seems "hinky". It was uploaded to the public domain, and the website it was taken from doesn't say anything about copyrights, but the image is originally from Stahl's Essential Psychophamacology. Fvasconcellos 14:45, 17 March 2007 (UTC)
 * Thanx, Fvasconcellos! CopperKettle 12:50, 20 March 2007 (UTC)
 * No problem :) Fvasconcellos 15:30, 22 March 2007 (UTC)

Someone pleas change the reference link
The reference link to the FDA warning letter should be: http://www.fda.gov/foi/warning_letters/archive/g4628d.htm —The preceding unsigned comment was added by Robertri (talk • contribs).
 * Done. Thank you for pointing that out. Fvasconcellos (t·c) 16:16, 2 May 2007 (UTC)

Rispen (generic brand) sold in the US?
The article states, that Rispen is a brand name od risperidon preparation sold in the USA. I know Rispen only as a generic version of risperidone manufactured and distributed by the czech/slovak pharmaceutical company Zentiva. Is it really sold under this trade name in the US..? Most of the google hits for "Rispen+US" seems to take generously this information from this article.--Spiperon 21:26, 3 May 2007 (UTC)
 * The FDA website makes no mention of Rispen. Tentative approval has been given to several formulations of risperidone, from several manufacturers, but none are marketed yet. It's probably just poor wording in the article—I'll clarify. Fvasconcellos (t·c) 22:08, 3 May 2007 (UTC)

New resource: Risperdal permitted for treatment of schizophrenia in children
http://news.yahoo.com/s/ap/20070822/ap_on_he_me/psychotic_drug I think this should be added. —The preceding unsigned comment was added by Special:Contributions/ (talk)

Some side effects are related to amount taken?
The psychiatrist who prescribes my Risperdal told me that many of the unpopular side effects of the drug, such as weight gain, only occur in doses of 4mg/day or more. I don't know the specifics, but I think that someone who has insight into this should change to article to reflect this. Bite the Wax Tadpole 21:28, 10 November 2007 (UTC)

92.235.205.104 (talk) 03:25, 23 June 2010 (UTC) I have taken 1mg of Risperidone per day since February 2008 and have experienced gradual but constant weight gain. I believe this can be controlled by reducing the amount you eat, but that the drug does induce hunger. I would welcome other accounts of this. —Preceding unsigned comment added by 92.235.205.104 (talk) 02:46, 23 June 2010 (UTC)

I think one of the extra pyramidal side effects is dry mouth and a feeling of thirst. Someone who consumes carbonated beverages high in sugar my unknowingly increase their intake significantly. I switched to diet soda due to this observation in my consumption of beverages and think it may be relevant to diabetes. —Preceding unsigned comment added by 64.53.203.180 (talk) 01:10, 28 August 2010 (UTC)
 * Extrapyramidal side-effects are movement disorders (tremor, dyskinesia Parkinsonism, etc). That's not quite the same thing. Though eating right would certainly reduce your risk of diabetes. 174.108.96.130 (talk) 07:14, 15 September 2010 (UTC)

Long-term effects after risperidone cessation
In my experience, there are none, apart from the permanent losses of experience and the way that impacts on your life. And a short-ish period of three weeks to a month after cessation for the mental faculties to return. From at least one testimony I have found on a bulletin board, the return of faculties may vary from person to person... but the fact that in my case they came back seems to show that the drug is not responsible for any prolonged or permanent loss of the faculties. Since I think I only found one example of permanent loss perhaps it is not worth reporting.

On the one hand it would seem appropriate for an article like this to cite a study on long-term effects - perhaps someone could research? On the other hand my experience says it all really, probably more clearly and usefully than any convoluted study.

Anyone reading up on their medication will be crucially interested in this information. When I was on this med I was searching desperately on the web and found very little. I hope someone with more nouse will post what I have written on the main page. Personally I am inhibited by the scientific character of this page, but I appreciate there may be legal issues. Actually that was my main reason for not posting this. I imagine the big pharma breathing down the neck of wikipedia for example in including my comment about the "mental faculties returning", implying as it does (and truthfully) that mental faculties are blocked by the medication. That fact does not seem to enter the official literature/ leaflet that comes with the drug.

Anyone with half an eye on these words should be alert by now to the fact that I am drawing attention to a very real and important instance of public misinformation, which so far Wikipedia has shown no sign of addressing. I am talking about the loss of creativity, memory loss, loss of reasoning ability, verbal ability, and other higher thought processes. I do remember looking for this sort of information in the past and it is very hard to come by, you only find it scattered across various bulletin boards. Of course different people report different incidences of loss of each of the faculties I mentioned. But side-effects profiles are just as imprecise, and it is these primary effects which are most important of all. They should all be mentioned as potential effects of the drug.

Whether or not this information can be included on legal grounds I do not know, but someone should certainly post the info I provided about the long-term effects of risperidone. The news is good, it should hardly be controversial. It just needs rephrasing re: mental faculties returning. —Preceding unsigned comment added by 79.69.65.238 (talk) 19:54, 20 December 2007 (UTC)

I agree the facts on effects are light, could you be more specific in your use of mental faculty? —Preceding unsigned comment added by 64.53.203.180 (talk) 01:06, 28 August 2010 (UTC)

Generic Availablity
While generic risperidone is not expeted at US pharmacies until after June 2008, legitimate Canadian pharmacies have generic risperidone available now, and do ship to the US. One should be careful not to use an email spam to find such a pharmacy. A prescription that would cost $800 at a US pharmacy may be available for $100 from Canada. Manufacturers of the generic include known companies such as Sandoz. A written prescription from your psychiatrist is required. The Canadian pharmacy may require that the prescription be mailed to them, however, in some cases a FAX is acceptable.69.110.0.187 (talk) 06:01, 18 February 2008 (UTC)

brave new world
Not directed to improving article. Collapsed.--Garrondo (talk) 10:51, 19 May 2013 (UTC)  Content not directed to improving the article

"It also helps the physician ensure compliance" -- scary —Preceding unsigned comment added by 66.188.187.164 (talk) 01:13, 27 April 2008 (UTC)
 * Oh, if you want to know scary. They had me on Risperdal four years ago, and screwed me up bad. They changed it to Seroquel and I got radically better, and refused to quit taking the stuff for fear of the horrible Risperdal effect to come back. Quit taking Seroquel cold turkey, and I feel better than I have in years. They screwed up my ability to think so badly I actually kept taking the crap. These things are really dangerous, and they should be really careful. Though, uh, yeah freaking right, like they're actually going to be. 174.108.96.130 (talk) 06:46, 15 September 2010 (UTC)

Not scary at all. Believe it or not, many psychotic people believe nothing is wrong with them, and therefore try to avoid taking medication when in fact they really need it... Giltramirez (talk) 21:10, 7 November 2011 (UTC)

Bull crap Giltramirez..... Schizophrenia is just name calling and also there is no such thing as a hallucination for the spirit world is real and demons truly exist. The Holy Scriptures says in Thessalonians that Christians have a struggling against the wicked spirit forces in the heavenly places and against the world rulers of this darkness. Sounds a lot like many who have been stuck in psychwards like me. Both a struggling with the demons and the government who put me there so afraid of the demons. 2602:306:C518:6C40:61B1:B9B8:E848:31A7 (talk) 03:14, 13 May 2013 (UTC)

5-HT (serotonin) antagonism
Risperidone, does not block dopamine receptors as stated in the article. It blocks a class of 5-HT (serotonin) recpetors which are linked to weight gain (5-HT2C), its antipsychotic action (5-HT2A) and relief of some of the extrapyramidal side effects experienced with the Typical neuroleptics. The latter action, in fact, leads to an increased release of Dopamine from Mesocortical neurones. Striate —Preceding unsigned comment added by 77.103.15.54 (talk) 19:36, 14 May 2008 (UTC)

Hyperprolactinemia and Infertility
Speaking of Sexual Side effects it seems to me there should be some mention of the link between hyperprolactinemia (prolactin increase) and it's effects on fertility not just on pituitary tumors.. It seems relevant to understand that that may be a side effect especially in women. Sometimes when a doctor describes using this medication as a prophylactic measure it may have a double meaning... "Often the family physician has to deal with lack of cooperation from patients [with schizophrenia] when they are asked to use common forms of contraception. [As a contraceptive measure for such patients,] some family physicians rely on the infertility secondary to hyperprolactinemia caused by traditional antipsychotic agents"

from Kaplan B, Modai I, Stoler M, et al: Clozapine treatment and the risk of unplanned pregnancy. Journal of the American Board of Family Practice 8:239-241, 1995

I would appreciate some consideration of these side effects on the main page especially considering the high levels of hyperprolactinemia induced by Risperidone. Thank You. Clayoismynamo (talk) 18:49, 27 September 2008 (UTC)

Invega
Perhaps there should be a cross-link to the article on Invega, which is the active metabolite of risperidone recently patented by Janssen as a separate drug. Expert assistance requested. DQweny (talk) 20:51, 18 October 2009 (UTC)

Risperidone for PTSD
I was treated with Risperidone for PTSD. I didn't see anything that said it was FDA approved for it or it may help it. Has anyone been on it for PTSD? Can it be treated for PTSD?

I take it for other reason's but I believe it can be effective for PTSD. Although I won't explain why this may be useful because I'd be speculating on mechanism of actions from an uneducated position. —Preceding unsigned comment added by 64.53.203.180 (talk) 01:14, 28 August 2010 (UTC)

Risperdone without prescription on the net
First of all, is this true? Can Risperidone be obtained LEGALLY without prescription? Second, if not, who should I inform about all these on-lines sites that advertise the sale of R. WITHOUT prescription? This is insane! --Francesco Franco (talk) 09:26, 23 November 2009 (UTC)
 * If you are in the US, suspicious online pharmacies can be reported directly to the DEA. Have a look at the FDA's Protecting Yourself" page for more information. Fvasconcellos (t·c) 11:37, 23 November 2009 (UTC)

Dissolved/Chewed vs swallowing whole?
My grandson has been taking respiridol .5mg m-tabs for about 6 months. He has a hard time swallowing pills. Just wondering, can the .5mg pill be dissolved or chewed? He is supposed to start taking it. —Preceding unsigned comment added by 206.190.231.66 (talk) 13:23, 6 January 2010 (UTC)

There is an M-Tab available which is the pill that dissolves in your mouth. A word of caution- be VERY careful with this drug, especially if your grandson is young because I wish I had someone looking out for me when they put me on this poison that is known as Risperdal. I was on it for like 10 months and that 10 months seemed like an eternity in Hell- I really don't know how I stayed on it for as long as I did, other than I was just doing what the doctors told me. That whole experience taught me that just because a doctor or someone with a degree tells you that you need to take something, it doesn't mean shit because no one's word is golden except God's and they're not God. I was switched to Abilify for a while and that drug was A LOT better than Risperdal but at the same time, it wasn't good, so eventually I just stopped taking that. Since the beginning of this year I haven't taken any medications and I feel better than I've felt in a long time- I have no schizophrenic symptoms whatsoever and I feel better off the meds than I ever felt on them; I question if I really have schizophrenia because I was only diagnosed with schizophreniform disorder and the only time I've ever had symptoms related to schizophrenia is after I smoked marijuana (safe to say, I don't touch the stuff anymore- I'm not saying the weed caused my psychosis but I'd be kidding myself if I said it didn't play a huge role in it). I kind of went off on a rant but I'm just trying to help out someone because like I said before, I wish someone told me about all the horrible side effects and general effects that Risperdal causes/can cause.

diabetes
my dad got diabetes when a doctor (putting a 250 pound man on this should get him kicked out of the profession ) put him on this drug-off label for depression (he weighted 250 pounds at the time, now 8 years after contracting diabetes he is 300). This drug gives people diabetes. I went on it for OCD and now have low blood sugar. MY dad and i both went on it off-label and he was overweight at the time and 50, i was 170 pound 6"3' 18 year old. It gave him hyperglycemia (diabetes) and me hypoglycemia!

We are both disabled for the rest of our lives because of this shit medication. The people at jansen pharmaceuticals ruined the lives of two people for hundred of dollars in drug revenue.Peppermintschnapps (talk) 21:01, 21 January 2010 (UTC)

Questionable sources resource4risperdalinfo.com and yourlawyer.com/topics/overview/pituitary_tumors
Recently, the following two links were added to the article:

http://www.resource4risperdalinfo.com

http://www.yourlawyer.com/topics/overview/pituitary_tumors

Both of these links are to the promotion pages for lawyers working on risperidal personal injury cases. These sources are non-reliable, questionable sources according to the Verifiability: "Questionable sources are those with a poor reputation for checking the facts, or with no editorial oversight. Such sources include websites and publications expressing views that are ... promotional in nature." These sources must be deleted and replaced by peer reviewed scientific references. The Sceptical Chymist (talk) 17:11, 24 January 2010 (UTC)

You do realise that legal websites aren't likely to lie about medicinal statistics, as they themselves don't want to be discredited and in the path of a lawsuit from the pharmaceuticals. I'm sure if they were challenged they could pull all the reliable sources they needed. You're very good at removing sources and putting in citation tags, often where they aren't needed, but if you can't actually find more reliable citations to replace these, then don't. Furthermore, I brought in a third opinion from Literature geek  |  T@1k?, and he wouldn't have removed those sources, but perhaps added another source instead, to complement these sources, rather than just a citation tag replacement. Editor182 (talk) 23:56, 25 January 2010 (UTC)


 * I should have been clearer in what I meant Editor182, I meant that using substandard sources is better in my view than no sources. I meant that I would have looked for better sources to replace the poor quality sources, not to supplement the lawfirm sources. I have replaced the legal sources with peer reviewed sources. I did suggest that you search the peer reviewed databases such as pubmed for better sources; why did you not do this? Did you read WP:MEDRS like I suggested? I am giving you this advice as otherwise you are going to be in constant content and sourcing disputes.-- Literature geek |  T@1k?  01:59, 26 January 2010 (UTC)

To insure compliance.
The first question that arises from this is why is an adult being treated like a child? This kind of forced drugging discrminates against people who are unable to afford to leave the country during the period in which the psychiatrist is pursuing forcing them onto medications. Is this what we're striving for?
 * You, uh, feeling okay there, buddy? Your message didn't make too much sense. 174.108.96.130 (talk) 06:55, 15 September 2010 (UTC)

Neurological mechanism of action.
I find Wikipedia to be informative and use it as a regular source of information. However this article seems light on how this medication works, what parts of the brain it could possibly affect and how it relates to it's medicinal properties. I will attempt some research and would greatly appreciate anyone with some knowledge on this matter. There seems to be a trend, that the more commercial a medicine is the less is known about its mechanism of action and effects on brain function. Does anyone have suggestions as to a good starting place to find relevant information regarding this? —Preceding unsigned comment added by 64.53.203.180 (talk) 00:58, 28 August 2010 (UTC)
 * I'd love to see this information myself. Something about how little is listed, currently, on the page, seems... off. If you read the other pages, on antipsychotics, they tend to have a great deal of direct blocking action. I may not have experience, but uh, got another man about to do research himself. And, uh, by the way? Ignorance is certainly bliss. Study would probably make them look bad. 174.108.96.130 (talk) 06:59, 15 September 2010 (UTC)

Maybe, risperdal has brain boosting powers & can be used to enhance interlectuality of an individual. Allanmucheru (talk) 14:47, 20 June 2016 (UTC)

Synthesis
There needs to be a section on how this chemical is synthesized. 2602:306:C518:62C0:5C06:758E:E477:60D6 (talk) 23:13, 31 July 2012 (UTC)

http://www.drugsyn.org/Risperidone.htm — Preceding unsigned comment added by 2602:306:C518:6C40:61B1:B9B8:E848:31A7 (talk) 01:06, 13 May 2013 (UTC)

Someone needs to lift the drug synthesis information from this site and add it to Wikipedia articles with attribution. All these molecular building blocks need articles of their own also. 2602:306:C518:6C40:61B1:B9B8:E848:31A7 (talk) 02:17, 13 May 2013 (UTC)

i. Aluminum chloride, dichloromethane, room temperature, 3 h, ii. 6N hydrochloric acid, reflux, 5 h, iii. Hydroxylamine hydrochloride, ethanol, N,N-diethylenethanamine, reflux, 3 h, iv. Potassium hydroxide, water, reflux, 2 h, v. 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one hydrochloride, potassium iodide, sodium carbonate, N,N-dimethylformamide, 85 - 90 °C, overnight

Preparation of Risperidone is described in US patent 4,804,663 and and also in European Patent EP196132. Accordingly, 1,3-difluorobenzene 1 and 1-acetylpiperidine-4-carbonyl chloride 2 were reacted in presence of aluminum chloride using dichloromethane as solvent at ambient temperature to give 1-[4-(2,4-difluorobenzoyl)-1-piperidyl]ethanone 3. The compound 3 was further hydrolyzed by heating with 6N hydrochloric acid at reflux temperature to give (2,4-difluorophenyl)-(4-piperidyl)methanone 4. Compound 4 was then treated with Hydroxylamine hydrochloride in presence of N,N-diethylenethanamine as base using ethanol as solvent at reflux temperature to give (2,4-difluorophenyl)-(4-piperidyl)methanone oxime 5. Compound 5 on was then cyclized by stirring with potassium hydroxide using water as solvent at reflux temperature resulting in to 6-fluoro-3-(4-piperidyl)-1,2-benzoxazole 6. The final step involves condensation of 6 with 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one hydrochloride in presence of potassium iodide and sodium carbonate as base using N,N-dimethylformamide as solvent at elevated temperature to afford 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidyl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one also called Risperidone 7.

its not potent
its the leas potent antipsychotic Qwh (talk) 10:04, 9 May 2013 (UTC). Yes in many ways its quite a nice drug, with much less weight gain than Olanzapine, and it gives you a nice little lick when you take each oral tablet, which may help you change town, get a new job, flat or go to college or back to it. Late at night mixed with too much liquor and caffine, ie coffee, red bull it may make you a bit too loud and lippy. More than 1mg a day reduces sperm and with 4mg it will be minimal and 5mg close to zero, but generally this drug actually helps people have good sex. — Preceding unsigned comment added by 60.234.54.147 (talk) 03:27, 9 September 2014 (UTC)

Proposed Side Effect to be added to the article
Innapproiate wording close to disruptive. Also unsorced. Collapsed per guidelines about talk pages, but we could discuss anosmia as a side effect if sources are found. --Garrondo (talk) 06:51, 21 May 2013 (UTC)

 Content very innappropiately worded and unsourced

Posted here to arrive at consensus. Risperidone destroys sense of smell. You can not even smell your own feces or a dirty bathroom after being exposed to this medicine. The danger is you could end up drinking sour milk or go down on a dirty wife who has not washed herself. We have a sense of smell for a reason to protect us and prevent us from eating something rotten or dirty. 2602:306:C518:6C40:F02A:330C:11CC:ACDB (talk) 06:06, 21 May 2013 (UTC)

Histamine H2 antagonist properties?
What do these receptors, associated with gastric acid secretion, have to do with the nervous system? — Preceding unsigned comment added by 00AgentBond93 (talk • contribs) 13:05, 14 August 2013 (UTC)

13:28 edit
Can anyone chack this edit? I reverted it but am not sure.Super48paul (talk) 14:09, 22 September 2013 (UTC)

Adding side effects not found during FDA approval process
Side effects seem self serving to the drug manufacturer by only listin FDA approval testing side effects. Currently many lawsuits re breast growth in teen boys (gynomastia). Shjacks45 (talk) 00:06, 27 September 2013 (UTC)

Most of these TV commercials are lawsuits that don't seem to be the honest and complete truth. Where are the links for the lawsuits? 64.113.124.158 (talk) 23:42, 30 September 2013 (UTC)


 * For what it's worth I was one of the many affected by this side-effect. Forbes does have an article here about J&J settling these lawsuits ( http://www.forbes.com/sites/edsilverman/2012/09/11/jj-sees-male-breasts-and-quickly-settles-risperdal-suit/ ), but I don't believe that is technically an admission of wrongdoing or guilt; I'll see what else I can pull up. MWisBest (talk) 07:12, 4 June 2016 (UTC)

Addition of some side effects.
Could anyone add dysphoria as side effect, and muscle stiffness as they were there earlier? 78.156.109.166 (talk) 09:18, 24 October 2013 (UTC)

Autism
I'm Autistic and I'm irritable. As a matter of fact, I'm pissed. DON'T give Autistic folks drugs!! Autistic brains are fine as they are. We have a right to be "irritable." — Preceding unsigned comment added by 72.70.192.193 (talk) 06:37, 16 December 2014 (UTC)

How much is absorbed via IM injection
need to know


 * According to http://www.medsafe.govt.nz/profs/datasheet/r/RisperdalConstaNEWinj.pdf, absorption of the IM form is "presumably complete". Garzfoth (talk) 19:30, 19 March 2016 (UTC)

This should be up there and it's being suppressed intentionally.

 * https://www.ncbi.nlm.nih.gov/pubmed/26287371
 * https://www.cnn.com/2016/12/14/health/risperdal-lawsuit/index.html
 * https://www.forbes.com/sites/legalnewsline/2017/04/10/philadelphia-flooded-with-new-risperdal-lawsuits-trials-split-but-include-massive-verdict/
 * https://pennrecord.com/stories/510952812-risperdal-plaintiff-awarded-record-setting-jury-verdict-of-70-million-in-philadelphia-court

I understand we may have some people who work for J&J who think this isn't an issue but there's plenty of evidence and lawsuits that something is going on and it's clearly being pushed to the sidelines by people who edit this page. I'm not entirely sure why this is happening or why people are choosing to do it, but I'm going to leave this up here until this is settled. If nobody can give me a good reason to refute a federal study and a volume of evidence that there's litigation and the possibility of developing Gynecomastia from taking the drug, then I'm reporting the fact that someone is censoring it. Twice I've made the edit and twice it's been censored and it's apparent that someone doesn't want this going up here. — Preceding unsigned comment added by 108.48.66.91 (talk) 02:31, 28 February 2018 (UTC)
 * Not being suppressed that I am aware. On some drug pages adverse effects are split out -and they have been for this one. They are listed at List of adverse effects of risperidone which is linked in the adverse effects section.  I don't like that much.  The society and culture section also mentions lawsuits.
 * I think we should merge adverse effects back in here. Jytdog (talk) 03:06, 28 February 2018 (UTC)

acetylcholine release-promoter???
"In many respects, this medication can be useful as an "acetylcholine release-promoter" similar to gastrointestinal drugs such as metoclopramide and cisapride. " Any sources confirming this statement? what is the difference between "releaser" and "release-promoter" see this -> https://en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor#Individual Can anybody describe the machanism of this drug which promote acetylcholine release? I mean any proof of that statement — Preceding unsigned comment added by 178.235.88.248 (talk) 18:38, 11 July 2018 (UTC)

Ref
This ref supports the common side effects. Not sure why it was removed?

https://www.drugs.com/monograph/risperidone.html

Doc James (talk · contribs · email) 03:08, 24 October 2018 (UTC)
 * Still no comment by User:ATC. No we do not use case reports to refute high quality secondary sources. Doc James  (talk · contribs · email) 22:17, 24 October 2018 (UTC)


 * These three studies (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176371/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730062/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568649/) among others clearly write and indicate that atypical antipsychotics (i.e., Aripiprazole, Risperidone, Quetiapine, and Olanzapine) are less likely to cause movement disorder (Tardive Dyskinesia) than older antipsychotics. In fact, the MedlinePlus (a webpage owned by the US National Library of Medicine) did not list movement problems of any kind under the special precautions or common side-effects section on either the Risperidone, Aripiprazole, Quetiapine, or Olanzapine pages (https://medlineplus.gov/druginfo/meds/a694015.html, https://medlineplus.gov/druginfo/meds/a603012.html, https://medlineplus.gov/druginfo/meds/a698019.html, https://medlineplus.gov/druginfo/meds/a601213.html). Plus, I would consider MedlinePlus to be a more reliable resource than Drugs.com. ATC . Talk 23:38, 24 October 2018 (UTC)


 * The American Academy of Family Physicians also noted that "The atypical antipsychotic agent risperidone has a much lower incidence of this side effect" and "One of the more common side effects from conventional neuroleptics is tardive dyskinesia." (see here: https://www.aafp.org/afp/2001/0115/p362.html). So, I'd like the movement problems removed from the "common side effects." ATC . Talk 00:32, 25 October 2018 (UTC)


 * https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176371/ Case report from 2011
 * https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730062/ from 2008 and not about resperidone
 * https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568649/ Tardive dyskinesia is NOT the only movement disorder
 * https://www.aafp.org/afp/2001/0115/p362.html Is from 17 years ago...

The drugs.com link is to the "American Society of Health-System Pharmacists"

You do realize that the medlineplus link https://medlineplus.gov/druginfo/meds/a698019.html is also from the "American Society of Health-System Pharmacists"?

Drugs.com and the NIH have both bought licenses for it. The first is the professional version and the medlineplus one is the patient version. Doc James (talk · contribs · email) 03:47, 27 October 2018 (UTC)

add gynecomastia to side effects
Galactorrhea and gynecomastia are very common side effects. It should be mentioned in this article because these side effects are said to be rare when taking atypical antipsychotics like risperidone is. As far as I know there have even been lawsuits in the USA because of gynecomastia in young male adolescents. Gynecomastia in males cannot be reversed except by surgery.

Risperidone is even mentioned in wikipedia as "[being] notorious for causing" galactorrhea: "Of these, risperidone is the most notorious for causing this complication." See here: https://en.wikipedia.org/wiki/Galactorrhea

Source according to this article on wikipedia: Popli, A (March 1998). "Risperidone-induced galactorrhea associated with a prolactin elevation". Ann Clin Psychiatry. 10 (1): 31–3. doi:10.3109/10401239809148815. PMID 9622047. 2001:16B8:C2C3:F400:29C9:AF5:D68:4671 (talk) 10:44, 14 September 2021 (UTC)

Who Synthesised It?
Who actually synthesised this drug first I'm quite interested to know who the chemist responsible for the creation of the compound is and what else they may have created? 103.69.253.9 (talk) 13:04, 23 November 2021 (UTC)
 * See Paul Janssen article. CV9933 (talk) 19:30, 23 November 2021 (UTC)