Talk:Salmeterol

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I am an African American and I wanted to know why does asthma affect African Americans more so than their counterparts and also what part does salmeterol play? 130.156.7.236 16:35, 7 March 2007 (UTC)

In my observations Asthma is very non-discriminatory, thus affects all races. RonEJ 19:23, 17 March 2007 (UTC)

The National Center for Health Statistics disagree with user RonEJ and report that in 2004 the prevalence of [asthma] in black children was 12.5% compared to 7.1% in Hispanic children and 7.5% in white children. There are multiple genes which may affect which persons are susceptible to developing asthma, however environmental factors (allergen/tobacco smoke exposure etc.) play a role as well. Twin and family studies prove that asthma is very discriminatory... in Norway, for example, a study showed that the regular incidence of asthma was 6%, however if your identical twin suffered from asthma, you had a 17% chance of developing this disease. Regarding the first user's question regarding salmeterol. The Salmeterol Multi-Center Asthma Research Trial was a large trial of more than 26,000 patients which was terminated early due to an unexpected number of deaths in patients receiving the experimental therapy salmeterol, (which is a long acting beta agonist bronchodilator) versus albuterol (a short acting beta agonist bronchodilator). Post hoc analysis did reveal an increased risk of death in African American patients with asthma who received salmeterol. This study was flawed, in that none of the patients received inhaled steroids, which is standard therapy for asthma. A follow up study in the United Kingdom, the Salmeterol Nationwide Surveillance Study, did include patients receiving inhaled steroids. This study showed a trend toward adverse effects in the salmeterol group, however the result was not statistically significant, therefore a larger trial would be needed to resolve the issue. Also, this study did not perform a sub-set analysis to determine if a certain race was more susceptible to this effect. The current recommendation is to not use salmeterol without co-current corticosteroid therapy in asthma patients. It is important to remember that this only applies to asthma patients, and patients with COPD (chronic obstructive pulmonary disease; emphysema; chronic bronchitis) safely benefit from the use of salmeterol in conjunction with inhaled corticosteroids (hence the combination drug Advair). Lugogo NJ, Kraft M. "Epidemiology of Asthma." Clinics in Chest Medicine. 2006. 27(1):1-15. Northwest girl 08:02, 6 November 2007 (UTC)

"Disk-styled" Inhaler
What does this refer to exactly? Is it what's sometimes known as an accuhaler? I have one of those for flixotide, I think it might be worth noting if they are the same thing. cyclosarin (talk) 03:16, 24 March 2008 (UTC)

"disk styled" inhaler refers to a diskus (and the like) Chocobomastr (talk) 05:15, 8 November 2010 (UTC)

Release Date?
It was made "in the 1980s," but does anyone have a more specific date? I can't find anything on GSK's site or via web searches. 67.244.2.127 (talk) 00:26, 10 January 2009 (UTC)

Osmosis Wikipedia editing course
Hi I am a final year medical student who is working on this page to make it better. I would like to work more on the mechanism of action of the drug and other important details which is useful to make this page to give more valuable information to common people. Monica Gopalakrishnan (talk) 19:11, 17 July 2019 (UTC)

I really like how well the page is laid out. Its very concise and doesn't contain any extra information.

The only suggestions in my opinion are regarding the Side Effects and the Pregnancy subsection under Medical uses.

Side Effects: I feel like could be better if they were bullet points rather than a paragraph because reading through a list rather than having to sift through a paragraph might be easier.

In the Pregnancy and Lactation subsection there are references missing specifically for where the section describes animal studies on the drug and the studies done on rats. Also I am not sure if there is a specific reason but the heading can do without it being "bold" font.

Overall good job, I really like it. Pbnj1518 (talk) 18:43, 26 July 2019 (UTC)Pbnj1518
 * thank you for the review i have made the changes in the side effects section as suggested. the pregnancy and lactation subsection was already present and i could not find sources which tell about animal studies. it think its in bold font for people looking out if the drug is harmful during pregnancy or not. (Monica Gopalakrishnan (talk) 14:00, 29 July 2019 (UTC))

Ref 19 link dead
Is there a permanent link to this ( Ramanujan K (June 9, 2006). "Common asthma inhalers cause up to 80 percent of asthma-related deaths, Cornell and Stanford researchers assert". ChronicalOnline - Cornell University. )? The current link is dead.

zandperl (talk) 03:32, 26 August 2023 (UTC)