Talk:Scripps Research/Archive 1

Punctuation
A place in the second sentence of the article's first paragraph illustrates a punctuation matter of growing concern ---the dropped closing comma. It should be. . . San Diego, California,. . . .   It's a bit disquieting that this error growing rampant in our writing is getting through editorial control and is now found in many Wikipedia articles. — Preceding unsigned comment added by 68.59.95.54 (talk) 19:11, 9 September 2017 (UTC)

External links modified
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 * Added archive https://web.archive.org/web/20130104014950/http://www.scripps.edu/florida/research/tri/index.html to http://www.scripps.edu/florida/research/tri/index.html

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Some proposed updates
Scripps Research

Scripps Research, previously known as The Scripps Research Institute (TSRI),[1] is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, with a sister facility in Jupiter, Florida, the institute has over 200 170 laboratories employing 2,400  2,100 scientists,[2] technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world. [citation needed]

The institute holds nearly over  1,000  1,100 patents,[3] has produced 9  11 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world.[4][5] The Scripps Research graduate program is ranked[DD1] 10th 9th nationally in the biological sciences, 5th  6th for organic chemistry, and 2nd for biochemistry.[6]

In 2022, their Jupiter, FL campus became a part of the University of Florida. Many details of the reorganization are yet to be determined, or have not yet been made public Jupiter-based graduate students remain part of the Scripps Research graduate program. .

History

Scripps Research began with the Scripps Metabolic Clinic, founded near the current site in the La Jolla area of San Diego in 1924 by philanthropist Ellen Browning Scripps,[7][8] who was inspired by the discovery of insulin. In 1946, the metabolic clinic separated from Scripps Memorial Hospital.

In 1956, Scripps Research was renamed Scripps Clinic and Research Foundation to reflect its broader focus and management's renewed commitment to biomedical research. Harvard biochemist A. Baird Hastings joined the institute in 1959, followed by immunologist Frank J. Dixon and colleagues William Weigle, Joseph Feldman, Charles Cochrane, and Jacinto Vazquez in 1961, biochemist Frank Huennekens and microbiologist John Spizizen in 1962. Dixon was appointed director of research operations in 1974, and in 1977 these operations assumed the name of The Research Institute of Scripps Clinic.[9]

Upon Dixon's retirement in 1986, Richard Lerner, who had been chair of the Scripps Department of Molecular Biology, was appointed the research institute's new director. In 1989, the institute launched a graduate program. In 1991, as the result of a merger of hospitals, the research branch became part of a larger organization, the Scripps Institutions of Medicine and Science. In 1993, the research division separated from the clinical side, becoming an independent nonprofit organization under the name of The Scripps Research Institute (TSRI).[9] An additional campus in Florida was instituted in 2004.

Michael Marletta became president and CEO in 2012, assuming the position from Lerner.[10] Marletta announced his resignation on July 21, 2014, and James C. Paulson was subsequently appointed acting president and CEO.

In September 2015, Peter G. Schultz was appointed CEO, and Steve A. Kay, president.[11] Kay announced he was returning to the University of Southern California in August 2016.[12]

In October 2016, TSRI announced a strategic affiliation with the non-profit California Institute for Biomedical Research (Calibr). The two organizations had already collaborated on several research programs in recent years, including the development of an antibody engineering platform aimed at improving treatments for chronic diseases such as diabetes and COPD, and immune therapies for the treatment of cancer.[13] Calibr now represents the drug discovery and development division of Scripps Research.

In February 2017, 5AM Ventures' John Diekman was named chairman of the board.[14]

In July 2018, TSRI was officially rebranded to “Scripps Research.”

The Scripps Institution of Oceanography is often incorrectly associated with Scripps Research; it is in fact a nearby research facility that is part of UCSD. TSRI Scripps Research is a private nonprofit institute not directly associated with UCSD. Confusingly, the Scripps Institution of Oceanography was once called the Scripps Institution for Biological Research.

In 2022, Scripps Florida separated from Scripps Research and became a part of the University of Florida. , however they still retain the Scripps name.[15]

Features

Scripps Research's California campus is located on 35 acres (140,000 m2) of land between the Torrey Pines State Reserve and the University of California, San Diego in La Jolla. In Florida, Scripps Research occupies 30 acres (120,000 m2) adjacent to the John D. MacArthur campus of Florida Atlantic University in Palm Beach County, Florida.

Departments and centers

Building C houses the departments of Neurobiology, Cancer Biology, and Infectious Disease at Scripps Research's Florida campus. [DD2]

Scripps Research emphasizes interdisciplinary studies. Scripps Research scientists possess deep expertise in a range of scientific fields[citation needed] and are organized into five interrelated departments: Chemistry, Immunology and Microbiology, Integrative Structural and Computational Biology, Molecular Medicine, and Neuroscience.

The institute also incorporates the:

Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery[16]

Center for Metabolomics[17]

Center for Viral Systems Biology

Dorris Neuroscience Center[18]

IAVI's Neutralizing Antibody Center at Scripps Research[19]

The Pearson Center for Alcoholism and Addiction Research[20]

Scripps Research Alcohol Research Center

The Scripps Research Translational Institute[21]

Scripps Research Digital Trials Center

Skaggs Institute for Chemical Biology[22]

Skaggs Graduate School for Chemical and Biological Sciences[23]

Worm Institute for Research and Medicine[24]

West African Research Network for Infectious Diseases (WARN-ID)

California Institute for Biomedical Research (Calibr)[24]

Notable people

Among the 231 173 members of faculty are Nobel laureates Ardem Patapoutian, K. Barry Sharpless, and Kurt Wüthrich, as well as many other notable scientists, including Phil S. Baran, Donna Blackmond, Dale L. Boger, Benjamin Cravatt III, Roy A. Periana, William R. Roush, Paul Schimmel, Peter G. Schultz, Gary Siuzdak, Eric Topol, Charles Weissmann, Ian Wilson, Peter Wright, Chi-Huey Wong and John R. Yates.[25]

In addition to the Nobel laureates, the Scripps Research faculty includes numerous members of the National Academy of Sciences, National Academy of Medicine, American Academy of Arts and Sciences, National Academy of Engineering, American Association for the Advancement of Science and American Philosophical Society, as well as winners of the Wolf Prize in Chemistry and MacArthur Fellows Program ("genius grant").[26]

The board of directors includes John D. Diekman (founder of 5AM Ventures), William R. Hearst III (chairman of the board, Hearst Corporation), Ge Li (founder of WuXi AppTec), and Joel S. Marcus (founder, Alexandria Real Estate Equities, Inc.).

Research rankings[DD3]

According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world (LENS score of 18.1), followed by The Rockefeller University (LENS score of 15.4) and the Massachusetts Institute of Technology (MIT) (LENS score of 9.4).[4]

Scripps Research was noted as a standout in the Science Watch survey of "high-impact" papers in chemistry (1997–2008), ranked number one worldwide by citations per paper.[16]

Another measure of productivity, the Hirsch index (which has been published by Chemistry World), placed six Scripps Research scientists – Wüthrich, Sharpless, Lerner, Yates, Schultz, and Chi-Huey Wong – in the top 100 of 2,000 chemists rated. Science Watch placed Sharpless within the Top 10 list of its "Top 100 Chemists 2000–2010" based on citations impact; other faculty in the list were the late Carlos F. Barbas and John R. Yates.[27]

In addition, a Thomson-Reuters's list of researchers ranked in the top one percent by citations in their field (2002 to 2012) included TSRI researchers Phil S. Baran (chemistry); the late Carlos F. Barbas (chemistry); Dennis Burton (microbiology); Benjamin Cravatt III (biology and biochemistry); Pascal Poignard (microbiology); K. Barry Sharpless (chemistry); Eric Topol (genomic and digital medicine);[28] Ian Wilson (microbiology); Richard Wyatt (microbiology); and Jin-Quan Yu (chemistry).[29]

Medical contributions

Medical therapies based on Scripps Research findings include:[30]

Adalimumab (Humira) for rheumatoid arthritis and other inflammatory conditions

Belimumab (Benlysta) for lupus

Cladribine (Leustatin) for hairy cell leukemia

Purification of Factor VIII for hemophilia

Tafamidis (Vyndaqel) for transthyretin amyloidosis (ATTR)

Lucinactant (Surfaxin) for infant respiratory distress syndrome

Ramucirumab (Cyramza) for gastric and non-small cell lung cancer

Dinutuximab (Unituxin) for the childhood cancer neuroblastoma

Ozanimod (Zeposia) for multiple sclerosis

COVID-19 mRNA vaccines for protection against the coronavirus SARS-CoV-2[DD4]

Pegvaliese (Palynziq) for phenylketonuria[DD5]

Sacituzumab govitecan (Trodelvy) for urinary tract cancers[DD6]

Outreach programs

The California campus offers educational outreach programs for high school students and undergraduates interested in learning more about science.

Drew Duglan (talk) 16:25, 21 July 2022 (UTC) [DD6]The therapy was enabled thanks to Scripps Research work in click chemistry. This drug was commercialized by Immunomedics. The licensing agreement over this therapeutic is detailed here discussing Scripps Research: https://www.annualreports.com/HostedData/AnnualReports/PDF/NASDAQ_IMMU_2019.pdf

This is also detailed in the filing with the SEC: https://www.sec.gov/Archives/edgar/data/722830/000110465920108121/tm2030753-2_sc14d9.htm [DD5]Sources: https://www.scripps.edu/news-and-events/press-room/2019/20190326-rosen-roberts-ozanimod.html

https://cen.acs.org/business/phenylketonuria-once-neglected-disease-became/97/i27

https://news.usc.edu/trojan-family/seeking-pku-treatment-patients-families-rally-behind-scientists/

In the Raymond Stevens entry in Wikipedia, his lab was at Scripps Research until 2014. It was in those years preceding that that Stevens developed the treatment for phenylketonuria. [DD4]Andrew Ward and his laboratory team developed the first detailed images of the SARS-CoV-2 spike protein and then created a way to stabilize the protein for the creation of effective vaccines against COVID-19.

file:///C:/Users/Drew/Downloads/science.372.6539.227.pdf

Also acknowledged in the FDA announcement: https://www.nih.gov/news-events/news-releases/statement-nih-barda-fda-emergency-use-authorization-moderna-covid-19-vaccine [DD3]The image in parallel here needs to say Scripps Research instead of TSRI [DD2]The 2 images of FL need to be removed [DD1]US News and World Report 2022 Drew Duglan (talk) 16:25, 21 July 2022 (UTC)
 * Here is how this starts:
 * Delete all citations to sources which are self published by Scripps
 * Now delete all sentences which are not followed by a citation
 * If it is time to update the article, then this is the next direction. Thoughts? What next?  Bluerasberry   (talk)  21:59, 21 July 2022 (UTC)
 * If it is time to update the article, then this is the next direction. Thoughts? What next?  Bluerasberry   (talk)  21:59, 21 July 2022 (UTC)


 * I've added these changes. A couple of notes:
 * In https://www.usnews.com/best-graduate-schools/the-scripps-research-institute--68/overall-rankings/21775470034_control I saw 6th rank for biochemistry, not 2nd, so I changed this.
 * Can you find citations for
 * Center for Viral Systems Biology
 * Scripps Research Alcohol Research Center
 * Scripps Research Digital Trials Center
 * West African Research Network for Infectious Diseases (WARN-ID)
 * The other entries in this section have citations. Thanks. Dan Bloch (talk) 22:55, 21 July 2022 (UTC)

Some more proposed change
Thank you for your help @Danblochand @Bluerasberry

Some final proposed changes for now:

''The image and caption box at the top of the article now needs to be changed to reflect the new brand and what we have written in the text. I have attached the new image below to use, which I created in Wikimedia Commons. The text now needs to read:''

Established: 1924; 98 years ago

Faculty: 173

Staff: 2,100

Location: San Diego, California, US

Website: www.scripps.edu

2601:281:8280:620:F95F:C92E:95EA:AFA (talk) 14:10, 29 July 2022 (UTC)