Talk:Serotonin–norepinephrine–dopamine reuptake inhibitor

Article deletion
Many years ago, this article was focused on its title subject (as 99.9999% of encyclopedia articles are), noting that SNDRIs are a new frontier in psychopharmacology and that only a few are in clinical trials. Now it has transformed into an article encompassing every pharmacological class of medication. The entire purpose of having a separate article for a particular topic is to elucidate aspects that might come across as unnecessary detail when covering its broader, related/inclusive topic. If I knew nothing about psychopharmacology, I would be horribly confused after reading this. At best, this article is redundant; at worse, it is obfuscating the very subject it purports to clarify. This page, as of 2015 Dec 17, is unfit for publication and should be either revised or rewritten from scratch.Frostlark (talk) 17:31, 17 December 2015 (UTC)

This was formerly a much longer article. This longer version may be found in the history.

This article is complete and utter garbage. It seems like it was written entirely by one person, and that person seems very biased, ignorant and pretentious. —Preceding unsigned comment added by 72.200.115.120 (talk) 07:15, 2 October 2009 (UTC)

References list
Depression (Part 1) Guest Editors: John H. Kehne and Ronald S. Duman (April 07)

[http://dx.doi.org/10.1038/nrn1846 New approaches to antidepressant drug discovery: beyond monoamines. Olivier Berton and Eric J. Nestler]

The Genetics of Depression: A Review (Jul '06)

The Mesolimbic Dopamine Reward Circuit in Depression (Jun 06)

Serotonin Receptors as Targets in Drug Discovery and Medicinal Chemistry (Sep '06)

Serotonin-Dopamine Interaction as a Focus of Novel Antidepressant Drugs (feb 06)

[http://dx.doi.org/10.1038/sj.bjp.0706428 Neurotransmitter transporters and their impact on the development of psychopharmacology. Iversen Br J Pharmacol 147: S82-S88 2006]

Serotonin Reuptake Inhibitors: The Corner Stone in Treatment of Depression for Half a Century - A Medicinal Chemistry Survey.

Serotonin (5HT), Fluoxetine, Imipramine and Dopamine Target Distinct 5HT Receptor Signaling to Modulate Caenorhabditis elegans Egg-Laying Behavior Ji Ying Sze1 2005


 * Neuronal Targets of Cocaine


 * Dopamine

Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement (2007) J. Dalley

[http://dx.doi.org/10.1016/j.pbb.2006.12.006 Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. (2007)]

D2-Autoreceptors Chronically Enhance Dopamine Neuron Pacemaker Activity J Neurosci 2006 May 10; 26(19): 5240–5247.

Cooperative activation of D1- and D2-like DA receptors in the NAc shell is required for cocaine-seeking behavior in the rat (06) H.D. Schmidt

Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction (2006)

[http://research.yerkes.emory.edu/Howell/Synapse56.pdf Changes in extracellular dopamine during cocaine self-administration in squirrel monkeys. Synapse, 56:129-134, 2005.]

[http://dx.doi.org/10.1016/j.neuropharm.2004.06.032 Dopamine and drug addiction: the nucleus accumbens shell connection. Gaetano Di Chiara, Valentina Bassareoa, Sandro Fenua, Maria Antonietta De Lucaa, Liliana Spinaa, Cristina Cadonia, Elio Acquasa, Ezio Carbonia, Valentina Valentinia and Daniele Leccaa 2004.]



[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17407497&query_hl=12&itool=pubmed_docsum Difference in magnitude of psychostimulant-induced extracellular norepinephrine in the ventral tegmental area contributes to discrepant prefrontal dopamine outflow Pan WH, Hsieh MC, Wu HH, Lin SK. Addict Biol. 2007 Mar;12(1):51-8.]
 * Norepinephrine

Alpha-Noradrenergic Receptors Modulate the Development and Expression of Cocaine Sensitization (2006).

[http://dx.doi.org/10.1016/j.drugalcdep.2005.09.002 Role of the increased noradrenergic neurotransmission in drug self-administration. Wee S, Wang Z, He R, Zhou J, Kozikowski AP, Woolverton WL. 2005]

Neurochemical interaction between dopaminergic and noradrenergic neurons in the medial prefrontal cortex Wynn Pan, Sze-Yuan Yang, Shi-Kwang Lin

[http://dx.doi.org/10.1038/74839 Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Gainetdinov 2000]

Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys (95 Spealman)

[http://dx.doi.org/10.1124/jpet.106.108324 Effects of Combined Dopamine and Serotonin Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys. (2007)]
 * Serotonin

Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration ('05)

Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs (2005)

[http://www.pnas.org/cgi/content/abstract/101/1/372 Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. PNAS, January 6, 2004; 101(1): 372-377.]

Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels 04

[http://jpet.aspetjournals.org/cgi/content/abstract/300/3/831 Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys. JPET 2002 300: 831-837.]

[http://dx.doi.org/10.1016/j.yebeh.2005.07.014 The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant. Ronald B.P. Jobe 2005]

σ Receptors: potential medications development target for anti-cocaine agents (03) Matsumoto
 * σ–Receptors

Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides R. Matsumoto, K. McCracken (2002).

Pharmacological Characterization of Nicotine's Interaction with Cocaine and Cocaine Analogs J Pharmacol Exp Ther 1999 289: 1229-1236.
 * Cholinergic

Ritz* Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality '97

Ritz* Cocaine-induced convulsions: pharmacological antagonism at serotonergic, muscarinic and sigma receptors '97

[http://www3.interscience.wiley.com/cgi-bin/abstract/112098312/ABSTRACT In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. (2005)]
 * Na+ Channels

[http://www.springerlink.com/content/w98a86ta5f754d2j/ On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys. (2000)]

AMPA and NMDA Receptors in P2 Fractions of Cocaine and Cocaine–Prazosin-Treated Rats August 2006
 * Ionotropic Glutamate Receptors

Reduction of Corticostriatal Glutamatergic Fibers in Basic Fibroblast Growth Factor Deficient Mice is Associated with Hyperactivity and Enhanced Dopaminergic Transmission Dec 2006

Repeated cocaine administration differentially affects NMDA receptor subunit (NR1, NR2A-C) mRNAs in rat brain Mika Yamaguchi 1 2, Toshihito Suzuki 1 2 *, Shuzo Abe 2, Takafumi Hori 2, Hirofumi Kurita 2, Takashi Asada 2, Nobuo Okado 3, Heii Arai '02

Article re-written
I've re-written some of the article to remove irrelevant information and outdated clinical candidates. I've shrunk the size of the article significantly, however I think that perhaps adding more information about the three relevant neurotransmitters roles in depression would be useful. It also needs more citations. Comrinec (talk) 16:40, 6 June 2010 (UTC)

Still too large article for such a small class of substances which includes especially cocaine
Most of the substances mentioned in the article are not triple "Serotonin-norepinephrine-dopamine reuptake inhibitors" "SNDRI". The article makes a long review of many other classes which are not at all "SNDRI". It speaks about MAOI, SSRI, SNRI which all of them are not at all "SNDRI" and have no relevance to the item. The main and most known "SNDRI" is cocaine, which is a psychostimulant abuse substance and recreational drug, which causes a high and dangerous craving, compulsive drug seeking, associated with the activation of specific reward structures in the brain, with daily or binges abuse, often dependence, intoxications with potential agitation, anxiety. paranoia or agressiveness, discontinuation syndromes often with severe depression. The presence of SSRi, SNRI, and other antidepressive medications which are not "SNDRI", and are not abusable substance, only is producing confusion among the readers, confusion between pharmacological treatment and substance abuse.Ewan2 (talk) 21:43, 4 July 2014 (UTC)

Dimebon
The part about magic bullet pharmaceutical drugs which gives dimebon as an example of an expecially efficient drug is contrary to new research about this substance and is also contradictory to the Wikipedia article on dimebon. — Preceding unsigned comment added by 217.209.169.236 (talk) 12:56, 14 January 2017 (UTC)
 * I've fixed this.  Seppi  333  (Insert 2¢) 22:52, 14 January 2017 (UTC)