Talk:Sickle cell disease/Archive 1

Amyloid
Someone added the ungrammatical statement that Hb polymerisation was a form of amyloid. It isn't, really. Amyloid is the accumulation of polymerised proteins in end-organs (kidney, heart, brain etc), which generally does not seem to occur in sicklers. JFW | T@lk  10:41, 4 Jul 2004 (UTC)

Pauling
Not a word about Pauling. Where do we insert this classical reference: L. Pauling, H. A. Itano, S. J. Singer, and I. C. Wells (1949) Sickle Cell Anemia, A Molecular Disease Science 110, 543 - 548. JFW | T@lk  00:47, 23 October 2005 (UTC)

New Treatments
I have edited this page in order to give new info to people looking for infomation about new treatments becoming available. I have given as much information as i know about what's coming out. Please give me a shout if theres an issue with my post. Also.. I was having poblems making links to the available websites that had more info for more research. I'm at HisNHers2006@yahoo.com I care about the subject and the site and I want to have the best info available for wiki users and people just checking it out. If you can help my post, please do. Also please contact me for updates.


 * Please don't sign your edits. Also, your addition read like an advertisement. I've changed it to reflect what Niposan actually is (phytomedicine). You are free to add the Cochrane Review, but leave external links for a to-be-written Niposan page. JFW | T@lk  15:54, 26 January 2006 (UTC)

ok gocha, but how about more on the new gene therapies that are being developed? I left a link to a great article ..did you see it? Is that bad wiki etiquette? Also How do wiki users contact each other to collaborate and discuss articles?


 * Sorry, it must have been an edit conflict (i.e. when I save my page just after you've saved a version). It's probably better not to use the "external links" section for sources. If you have a good source for the gene therapy of HbSS then please cite it. Unauthoratitive sources (i.e. not peer-reviewed) may be less ideal.


 * Talk pages are used to discuss articles. As for medical articles, there's a lot of physicians and medical students on Wikipedia_talk:WikiProject Clinical medicine, and people interested in medication at WikiProject Drugs. JFW | T@lk  21:46, 26 January 2006 (UTC)

Well-known victims
(talk) 14:47, 29 April 2008 (UTC)


 * Miles Davis, jazz musician.
 * Paul Williams, singer (The Temptations)
 * Georgeanna Tillman, singer (The Marvelettes)
 * Tionne "T-Boz" Watkins, singer (TLC)
 * Prodigy, rapper (Mobb Deep).
 * Jesse Jackson, Civil Rights activist


 * I removed this list, as it is unclear whether these people are "victims" or simply carry HbS. JFW | T@lk  00:40, 16 February 2006 (UTC)
 * I am not sure about Davis or Jakcson, but I know that Williams, Watkins, Tillman, and Prodigy the rapper had/have full-blown sickle-cell disease. Tillman in fact died from sickle-cell related complications, and Watkins is a spokesperson for the Sickle Cell Disease Association of America. --FuriousFreddy 01:29, 4 March 2006 (UTC)

Nigerian Well-known victims -Zulaha Hadejia -Saude Hadejia -Asmau Hadejia

Alive and living well with the disease,tho here in nigeria we have a limited knowledge of the disease. —Preceding unsigned comment added by 196.200.14.187 (talk) 21:34, 9 December 2008 (UTC)

JAMA 1989
Whoever wants to dip into the history of the discovery:. JFW | T@lk  00:48, 3 May 2006 (UTC)

Nigerian Treatment
Most of the information for the "Nigerian Treatment" does not belong in this article. I don't see how a US SEC document has anything to do with sickle-cell disease. The same with the comment about the Nigerian ruler. At least the trial results are relevant, although they are better served in notes. Of course, any kind of number like that has to be cited.

I look forward to seeing the citations and making this portion of the article as strong as the rest. TedTalk/Contributions 14:10, 21 July 2006 (UTC)


 * Couple points/suggestions: Firstly is the drug effective or not - for wikipedia the issue will be whether one can WP:Cite from a WP:Reliable sources to WP:Verify the information being added. This nneds to await the outcome on the phase III trials and the publishing in a peer reviewed journals - until then it repains a comapany/personal hope for the success of the research at confirming its claimed actions - this though is prohibited from wikipedia (for now) under WP:No original research. Secondly any information about the development of the drug, should be placed in a separate article about this drug, not within Sickle-cell disease - I'm just not sure that the drug is (yet) able to claim notability (given the absence of published research) and the article would likely be nominated for deletion (WP:AfD). David Ruben Talk 14:59, 21 July 2006 (UTC)

What what it is worth, here is the link to much of the information:. It is, of course, copyrighted. At least some of the material being added is copied directly from this source. A recent addition also had the words "Back to top" at the bottom of the addition, further suggesting it was cut-and-pasted from some as-yet-unknown website. Most likely, violating copyright. TedTalk/Contributions 20:37, 21 July 2006 (UTC)

Moved - I agree shame that original research not cited as opposed to the company's own selective quotes. However on searching PubMed some validation to the product found (not under current international & US names but its former research name of 'Niprisan'). A Cochrane review cautions that reduced crises episodes reported in a later larger trial was not match by reduced complications or rates of anaemia. However more pressing is that this drug is still being evaluated, yet currently occupies a length in the article greater than other established treatments. I have therefore cut it drastically, in this article, to just a mention under the "Future treatments" section, and moved the rest to a newly creatd article of Nicosan. I've given it a little more structure, started marking up the references with fuller citation details and will continue to add a few more papers to cite (I'ld be grateful if other editors could give me about an hour to add this extra material in). NB I've added the cochrane review as it added balance and thus NPOV to what was previously just a quote from the company's own claims. David Ruben Talk 23:37, 21 July 2006 (UTC)

STOP trial
The STOP trial has shed some light on the use of transfusion to prevent stroke in children with HbSS and the role of transcranial doppler. JFW | T@lk 20:14, 26 July 2006 (UTC)

what does this mean?
from the first paragraph: "Once the two mutated genes inherited from each parent link together, the DNA nucleotides are pushed into the bloodstream after the "T" is replaced with a "G". The nucleotide then copies itself in the bloodstream and it eventually makes the proteins inside the bloodcells stretch out and form into a sickle shape. The whole paragraph is really confused and confusing and some of it doesn't make sense (The nucleotide then copies itself in the bloodstream??) Does anyone want to write it better? (I'd like too but I'm not sufficiently informed) Plch 22:34, 17 March 2007 (UTC)


 * Whoa--that sounds pretty bad. I'll have a look.--Dr.michael.benjamin 03:32, 18 May 2007 (UTC)

physical appearance
this article lacks that it makes you look pale.


 * Most patients are black, and pallor is much harder to detect is that ethnic group. The conjunctivae/sclerae may look pale, but will be jaundiced in a crisis. JFW | T@lk  15:05, 12 September 2007 (UTC)

What is "black"? This doesn't sound like a scientific or medical determination. Please re-word to refer to "darker skin" or climatic region. Leon Spencer, Animis Opibusque Parati 00:49, 31 March 2008 (UTC)


 * This is the talk page. Scientific terminology is not required. --78.86.137.221 (talk) 13:57, 10 April 2008 (UTC)

Thrombotic risk
There appears to be an increased thrombosis risk. addresses this is more detail. JFW | T@lk  15:05, 12 September 2007 (UTC)

Advances in treatment
This article from The Washington Post (December 7, 2007) gives evidence that there are advances in treating sickle cell anemia underway. Granted it's in mice, but perhaps it should be documented here? I personally don't feel capable of doing anything constructive or encyclopedic with this info, but if anyone has a way to find more references and come up with a good way of introducing the topic, it seems worthy of inclusion. Any thoughts? Isaiah (talk) 13:36, 7 December 2007 (UTC)

"sickle-cell" or "sickle cell"?
Can someone please standardize the use of the term "sickle-cell" or "sickle cell" throughout the article? I see the term used interchangeably with or without the dash all over the place. I'd do it myself, but I'd prefer that we use the more correct spelling, if there is one, and I don't know which that is. Considering the title of the article I'd go with the one using the dash currently, but I think a more authoritative source is in order. Thanks. -- Hi  Ev  07:55, 16 December 2007 (UTC)

When "sickle cell" is used adjectivally, it should be hyphenated. And when it is used nominally, it should be broken with a space. So, "sickle-cell disease involves sickle cells" is not inconsistent but standard English. 68.188.2.182 (talk) 01:13, 9 February 2008 (UTC)

Hb F formation
The defect does not lie in the delta chain. So is also the case in Thalessimias. Then why does Hb F predominate in Sickle Cell Disease and Hb A2 predominate in Thalessimias when both should be raised in both the diseases. 59.180.25.104 (talk) 12:16, 28 February 2008 (UTC)Bis

Duplicate entries
Most information listed under "Vaso-occlusive crisis" is listed again under "Complications". But I'm new here, so I'm not comfortable changing it myself. Someone may have done it on purpose, after all. —Preceding unsigned comment added by 64.198.112.213 (talk) 16:09, 29 February 2008 (UTC)

I think it is also a reasonable edit that needs to be made since information is listed twice.--DavidD4scnrt (talk) 07:48, 16 April 2008 (UTC)

Mostly Sub-Saharan Africa?
Article cites "Sickle-cell disease occurs more commonly in people (or their descendants) from parts of the world such as sub-Saharan Africa..." This is incorrect. "Sub-Saharan Africa" is a geologicial region - not a group of people. I think you want to say tropical and subtropical climates around the world. Sickle-cell (or the trait) has long been common in people of African descent due to climate - since ancient times.

Yahoo Article:Study shows life was tough for ancient Egyptians

"Studies on the remains of ordinary ancient Egyptians in a cemetery in Tell el-Amarna showed that many of them suffered from anemia, fractured bones, stunted growth and high juvenile mortality rates, according to professors Barry Kemp and Jerome Rose, who led the research."

An article citing the history of sickle-cell:

"Although the disease does not distinguish between the rich and the poor, it does single out those from the tropical and subtropical climates of the Old World...One long-held theory as to why it was so common in the tropics was its association with malaria. In the 1940s, E.A.Beet, a British medical officer stationed in Northern Rhodesia (now Zimbabwe), observed that blood from malaria patients who had sickle cell trait had fewer malarial parasites than blood from patients without the trait. Following this observation, a physician in Zaire reported that there were fewer cases of severe malaria among people with sickle cell trait than among those without it."--Innvista Health Leon Spencer, Animis Opibusque Parati 00:46, 31 March 2008 (UTC)

The reference to "sub-Saharan Africa" is grammatically correct (you seem to have overlooked the preceding phrase). You are incorrect to say that sub-Saharan Africa is "a geological region". It is not. I think you mean "a geographical region". — Preceding unsigned comment added by 86.130.190.87 (talk) 13:31, 5 January 2013 (UTC)

Sildenafil for PAH in SCD
JFW | T@lk  15:18, 2 April 2008 (UTC)


 * Genes that increase risk of PAH - . JFW | T@lk  14:30, 13 June 2008 (UTC)

NIH consensus conference
The NIH held a consensus conference on 17–22 September 2007. Hydroxyurea was discussed in extenso.
 * http://www.annals.org/cgi/content/full/0000605-200806170-00221v1 - evidence-based review
 * http://www.annals.org/cgi/content/full/0000605-200806170-00220v1 - consensus statement

It's actually fascinating that despite all the reviews and conferences, longer-term outcome trials are still sparse. JFW | T@lk  05:40, 6 May 2008 (UTC)

Differentiate between disease and trait
People who have the sickle cell trait (one recessive gene) do not have 'sickle cell disease' or 'sickle cell anemia.' They have 'sickle cell trait.' This article should probably reflect that. Woland (talk) 21:03, 20 May 2008 (UTC)


 * True, although typically will have slightly lower haemoglobin levels than the norm and in extreme conditoins might still have crises (eg high altitude mountaineering, commercial aircraft depressurisation and medical/surgical problems causing hypoxia). But I agree the absence of any mention of trait status in the leadin and just single line in Sickle-cell disease section needs correcting. David Ruben Talk 02:12, 21 May 2008 (UTC)
 * There is an article Sickle cell trait (in a very sorry state with manual reference numbering - I'll fix that too), which has a disambinguation note at its top to this Sickle-cell disease article, I'll reciprocate the same back David Ruben Talk 02:30, 21 May 2008 (UTC)

Disease vs. illness
The text was just changed, all 'disease' became 'illness'. Not a way. I think it should be changed back. --Dumarest (talk) 11:30, 9 June 2008 (UTC)
 * No discussion has happened - someone changed the Infobox back to disease - I will revert. Sickle cell is a disease, not just an illness. --Dumarest (talk) 17:34, 10 June 2008 (UTC)

NCEPOD
Really not sure if it needs direct mention, but the UK NCEPOD has reported on sickle cell disease: http://www.ncepod.org.uk/2008sc.htm JFW | T@lk  15:38, 26 June 2008 (UTC)

Sickle cell crises
Wondering if we should move the sickle cell crises info to its own page? There is a big difference between the condition most of the time and during crises.--Doc James (talk) 18:56, 20 December 2008 (UTC)


 * In my opinion, no - this is a significant part of sickle cell disease, and needs to be detailed under this topic, not a new one. --Dumarest (talk) 12:07, 21 December 2008 (UTC)

File:Malaria distribution.jpg
This map isn't accurate (compare to File:Paludisme - Frequence statistique.png), does it show historical rather than modern distribution? Tim Vickers (talk) 22:20, 16 January 2009 (UTC)
 * I've compared it. It's not inaccurate per se as much as it is incomplete - leaving out the South Pacific and South America.  You can add that map for completeness. MartinezMD (talk) 03:17, 17 January 2009 (UTC)
 * There is no endemic malaria in southern France or Italy. Tim Vickers (talk) 21:15, 17 January 2009 (UTC)


 * It is probably more historic and I'll make a note on the map. It may not be gone completely however: "Nowadays, all the malaria cases reported in France are only imported cases [10], excepted for three suspected, but not-confirmed, autochthonous cases in 2006."  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1808464 --MartinezMD (talk) 21:40, 17 January 2009 (UTC)

Endemic malaria was quite prevalent in certain areas of Europe until the 19th century at least. When they dealt with the swamps, things got a lot better. I am certainly aware of reports of malaria in Northern Germany in the early 19th century. JFW | T@lk  09:08, 18 January 2009 (UTC)

Radiotherapy treatment
On the website of the BBC, I just read about a woman who received radiotherapy treatment for sickle-cell anaemia. This might lead to an interesting addition to the article, if anybody knows a bit more about the subject. -- Irene1949 (talk) 19:04, 16 February 2009 (UTC)


 * The article doesn't explain what the radiotherapy was meant for. I've personally never heard of this. Could she have had areas of bothersome extramedullary haematopoiesis that needed silencing? Dunno. JFW | T@lk  10:46, 8 April 2009 (UTC)

Review on pharmacotherapy
Br J Haem this week. JFW | T@lk  10:46, 8 April 2009 (UTC)

History and the name
The recent vandalism has made me look at the names. The person credited for naming it "sickle cell anemia" is currently listed as Vernon Mason in 1922. It is unreferenced. On a casual Google search I don't come across his name independently except where it was mirrored or sourced from here. I do find an E.Vernon Hahn as an early investigator (1927). Do we have the facts correct here? --MartinezMD (talk) 21:29, 21 April 2009 (UTC)

Unreferenced Section
Hi, ive seen a sentence thats implys that sickle-cell disease affected person had a 0.8 chance per year of having a crisis which it says on another part of the article that the chance of having a crisis varys greatly between patients that has a reference whereas this just says "citation-needed". Should this be changed? Spykid99 (talk) 07:01, 22 April 2009 (UTC)

Inheritance
I have just removed sort of duplication in this section -- but I am unsure of part of this. The inheritance material is duplicative, but is sickle-cell actually a codominant allele? --Dumarest (talk) 12:05, 12 July 2009 (UTC)

According to Brooker (2005) sickle-cell is an example of overdominance; not codominance. Overdominance is when "a heterozygote is more vigorous than both of the corresponding homozygotes" (p. 84). In this particular circumstance, the heterozygous disease has an advantage over the homozygous dominant because it allows the body to be resistant to malaria. Brooker also describes codominance. It is "the phenomenon in which two alleles are both expressed in the heterozygous individual" (p.81). A perfect example of codominance is blood type. People can have type A, B, AB, and O blood. Each allele can have I^A, I^B, and i. Since both alleles are expressed there is codominance (p. 81). Furthermore, the description of sickle cell disease inheritance is extremely similar to the description of Simple-Mendelian inheritance. Therefore, the proper statement should read "Sickle-cell disease (SCD), or sickle-cell anaemia (or anemia; SCA) or drepanocytosis, is an autosomal recessive genetic blood disorder, with overdominance, characterized by red blood cells that assume an abnormal, rigid, sickle shape." User Dumarest was onto something!

Reference: Brooker, R.J. (2005). Genetics: Analysis & principles (2nd ed.). New York: McGraw Hill. — Preceding unsigned comment added by Mattemerson (talk • contribs) 01:07, 15 March 2011 (UTC)

Life Expectancy
Are the life expectancies in the first paragraph still accurate? The article cited to support them was published in 1994, and the patients in the study were enrolled between 1978 and 1988. Treatment has evolved significantly since the 80's. Are there any recent studies that investigate life expectancy? Whizot (talk) 00:52, 18 January 2010 (UTC)
 * Well I tried adding that specific point to the article (saying that it was data from an older article) and I was rebuffed in my edits. I haven't researched it to know if there are longer life expectancies, especially if the person can be treated.--MartinezMD (talk) 02:24, 18 January 2010 (UTC)

Sickle Cell Disease vs. Sickle Cell Anemia
I believe it is confusing to use both above terms, Sickle Cell Disease and Sickle Cell Anemia interchangeably when they aren't interchangeable.

Sickle Cell Disease according to: Sickle Cell Disease Association of America [[Media:(www.sicklecelldisease.org]]) "refers to the group of inherited blood disorders that affect red blood cells and due to abnormal hemoglobin S. Sickle Cell Anemia on the other hand refers to specific forms of the disease which based on their point mutation are expressed in different ways.  Some of the common forms of Sickle Cell Disease are: Sickle Cell Anemia SS, Sickle-Hemoglobin C (S,C), Sickle Beta Plus and Sickle Beta Zero Thalassemia."

Wikipedia states: "Sickle-cell disease, or sickle-cell anaemia (or drepanocytosis), is a genetic life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. When above delineaion is explained then the first sentence on the Wiki page is incorrect.  Please consider changing.  --MTD2010 (talk) 07:31, 25 February 2010 (UTC)


 * Related is the recent addition to the article of "SCA" and "SSA" - they struck me as incorrect but in fact I find that both these terms are in use, in scientific journals. So I guess that change should stay. Dumarest (talk) 16:57, 4 March 2010 (UTC)

sickle cell and native americans (Indians)
There is no African American in our families and my daughter was asked if American (Indian) blood possible. I see nothing on the subject and would like to know more. There is Indian on both sides of family. —Preceding unsigned comment added by 75.228.209.58 (talk) 19:09, 9 May 2010 (UTC)

missing spaces
Some sentences are not seperated with a space after the period.

I'm unable to edit it... —Preceding unsigned comment added by 87.69.218.34 (talk) 08:00, 15 May 2010 (UTC)

Treatment/Management
Desfaral for the chelatation of excess Iron (due to HbS breakdown) —Preceding unsigned comment added by Avkrules (talk • contribs) 06:42, 6 July 2010 (UTC)

Sickle-cell disease and trait.
Are the two different (if so how) do we need to consider merging?Suitrader (talk) —Preceding undated comment added 04:59, 15 August 2010 (UTC).

Sickle-cell anemia and HIV
I've heard that those who have sickle-cell disease are virtually unaffected by the human immunodeficiency virus, yet I see no mention of it in this topic. Should it not be mentioned? Thanks, Topcount345 (talk) 08:13, 15 August 2010 (UTC)
 * That is probably incorrect. It is true for Malaria, but not for HIV. Wapondaponda (talk) 11:47, 15 August 2010 (UTC)

"Invitation to edit" trial
It has been proposed at Wikipedia talk:Invitation to edit that, because of the relatively high number of IP editors attracted to Sickle-cell disease, it form part of a one month trial of a strategy aimed at improving the quality of new editors' contributions to health-related articles. It would involve placing this:"You can edit this page. Click here to find out how."at the top of the article, linking to this mini-tutorial about MEDRS sourcing, citing and content, as well as basic procedures, and links to help pages. Your comments regarding the strategy are invited at the project talk page, and comments here, regarding the appropriateness of trialling it on this article, would be appreciated. Anthony (talk) 12:06, 31 August 2010 (UTC)


 * It would be nice to have useful contributions. Too many of the anonymous IPs are vandals.  Also, I have previously requested the article be semi-protected and was told there wasn't enough IP vandalism.  So which is it: too many IP's or not enough?  Because it is not logical.--MartinezMD (talk) 21:05, 31 August 2010 (UTC)


 * Hi MartinezMD. If this article forms part of the trial, I'll be able to provide you with stats for percentage of vandalism edits. Hopefully, if the "Invitation to edit" works, without boosting vandalism, you'll have more help from constructive editors with some clue about our policy on editing medical articles.


 * The list of articles for the trial is being reconsidered at the moment, in light of feedback from editors, and we should know in a few days whether Sickle-cell disease will be involved. If you have any thoughts about the Invitation to edit proposal, they would be very welcome at the project talk page. Anthony (talk) 15:00, 2 September 2010 (UTC)

Crisis in sickle cell trait
Just heard on the news about a find of old slides, showing a sickle cell crisis in sickle cell trait under a situation of difficult breathing resulting in low oxygen in the blood, slides from the early 20th century. Any more data on this?? (Dumarest (talk) 12:20, 29 November 2010 (UTC)).
 * It's the last addition to the article, but not described specifically as trait. It was recently removed but I put it back in as a smaller mention.  look in the history section.MartinezMD (talk) 14:52, 29 November 2010 (UTC)

Lancet
Review: JFW &#124;  T@lk  08:32, 8 December 2010 (UTC)

Overdominance
Indicated in a recent edit. What does that word mean?? (Dumarest (talk) 02:04, 15 March 2011 (UTC)).
 * It's defined a couple of times on this talk page. Look above.MartinezMD (talk) 11:34, 15 March 2011 (UTC)

Need for work
The article is currently mostly based on primary research studies. WP:MEDRS needs to be applied. The Lancet review above can be used to replace a lot of primary sources, and I think it should be easy to find other recent reviews. JFW &#124; T@lk  10:36, 30 January 2011 (UTC)


 * Most of the Cochrane reviews seem to conclude that there's too little data! ( on priapism, on fluids in crisis, etc.)


 * - pulmonary complications, Chest 2010 (but NEJM 2008, probably just as good)
 * - eye complications
 * - casting doubt on the NO hypothesis of PAH in SCD (this will need mentioning!)
 * - systematic review on invasive infections (African children only)
 * - a rare source dealing with the painful crisis
 * - gastroenterological complications (unsure re impact factor)
 * - SCD and stroke (Blood)
 * - systematic review of hydroxyurea in children
 * - idem in adults
 * - pain syndromes


 * Let's see if I find the time... JFW &#124; T@lk  14:36, 30 January 2011 (UTC)

Free/Simple language Sickle Information Resource Compilation
I would request all of you to kindly participate in the simple language wikipedia article on Sickle-cell_disease and also I have started a list of useful resources here simple:Talk:Sickle-cell_disease..Kindly collaboarate nd build up this list.. and if possible create a wikiproject protal for it.. It will help thousands of english speaking as well as non-english speaking patients and families.. as we can easily use that template and translate it into other language wikipages and make those pages more lucid and user friendly rather than keeping this subject only for scholars who can always read the english regular version..Thanks and regards --Dr.saptarshi (talk) 11:29, 22 April 2012 (UTC)
 * I will work on this article as I have time :-) We should try to use the ideas in some of the sources above but just simplify the wording. With respect to the main Wikipedia we typically use secondary sources (either review articles or major textbooks) Doc James  (talk · contribs · email) 21:11, 22 April 2012 (UTC)

Remove redirect
I would like to suggest not redirecting Hb S to the Sickle-cell disease page. Other variant hemoglobins (Hb C, Hb E) have their own entries, and so should Hb S. Although obviously highly relevant to Sickle-cell disease, it is nevertheless a separate entity. 86.29.186.248 (talk) 12:42, 25 July 2012 (UTC)

Haemoglobin/hemoglobin
And that comes up again! I am getting tired of the multiple editings changing the 'e/ae' letters. We need an editorial ruling! (Dumarest (talk) 11:40, 27 September 2012 (UTC))


 * You don't need an editorial ruling. There is clear policy on this. WP:RETAIN and WP:ENGVAR. The article started in British English style and stays that way unless there is reason to change it.  There are no strong national ties to the subject, so I don't see what the need to change would be. MartinezMD (talk) 19:44, 27 September 2012 (UTC)

71.127.55.155 (talk) 04:08,

To All My Friends On Shore
Curious as to why my mention of the movie TO ALL MY FRIENDS ON SHORE was deleted as not being in good faith. Certainly it was not intended as malicious, and I believe that the film was the first instance of sickle cell anemia being brought to the attention of the public. It was also a critically acclaimed effort. A quick check of Internet Movie Data Base will show that it was not regarded as trivial, but as an important production that is still regarded by many as top-notch in both screenwriting and production. I'm personally not aware of any efforts to dramatize the plight of sickle cell victims since that film came out in 1972, which I also find notable.

Anyone have any thoughts on this? I'd like to know if there could be a "in popular media" section added, or if some revision of my initial effort would be more acceptable.

Thanks Oldsmobile (talk) 04:14, 28 November 2012 (UTC)

Priapism
A troublesome complication reviewed 10.1111/bjh.12199 JFW &#124; T@lk  19:50, 7 January 2013 (UTC)

Cerebral vasculopathy
10.1111/bjh.12300 Br J Haem 14:54, 25 April 2013 (UTC)

More treatment, vicar?
10.1111/bjh.12413 JFW &#124; T@lk  19:28, 17 June 2013 (UTC)