Talk:Sotrovimab

Sotrovimab has a different mechanism against Omicron variants, compared to Evusheld
Sotrovimab has a different mechanism against Omicron variants, compared to Evusheld.

"Sotrovimab S309 and EvuSheld AZD7442 have different mechanisms of protection against Omicron variants, with S309 utilizing Fc effector function interactions and AZD7442 acting principally by direct neutralization".

https://www.biorxiv.org/content/10.1101/2022.03.17.484787v1

Preprint, Posted March 18, 2022.

So it would be theoretically best to give patient both antivirals, EvuSheld and Sotrovimab.

The problems or issues with Sotrovimab, compared to AstraZeneca Evusheld I can think of:


 * Higher price


 * Needs to be given intravenously. Evusheld is given as an injection to butt.


 * Shorter half-life? For how long does it work? So doesn't work prophylactically unlike EvuSheld, which works for several months?

Manufacturer press releases:

Sotrovimab: https://investors.vir.bio/press-releases/

EvuSheld: https://www.astrazeneca.com/media-centre/press-releases.html

--91.159.188.253 (talk) 15:04, 11 June 2022 (UTC)


 * Wikipedia is not an online discussion forum. Maybe you can try to discuss about this medicine on X-Twitter ? Wisdood (talk) 12:02, 29 May 2024 (UTC)