Talk:Substance P

- Involvement of substance P and the NK-1 receptor in human pathology.
Muñoz M1, Coveñas R.

Amino Acids. 2014 Jul;46(7):1727-50.

doi: 10.1007/s00726-014-1736-9.

Epub 2014 Apr 6.

Involvement of substance P and the NK-1 receptor in human pathology.

Abstract [excerpt]


 * The peptide substance P (SP) .... . After binding to the neurokinin-1 (NK-1) receptor, SP regulates many pathophysiological functions in the central nervous system, such as emotional behavior, stress, depression, anxiety, emesis, vomiting, migraine, alcohol addiction, seizures and neurodegeneration. SP has been also implicated in pain, inflammation, hepatitis, hepatotoxicity, cholestasis, pruritus, myocarditis, bronchiolitis, abortus, bacteria and viral infection (e.g., HIV infection) and it plays an important role in cancer (e.g., tumor cell proliferation, antiapoptotic effects in tumor cells, angiogenesis, migration of tumor cells for invasion, infiltration and metastasis). ...

[PubMed - in process]