Talk:Sulfonamide (medicine)/Hisashi Bob Iwahashi

If the -NH2 group of R1-S(=0)2-NH2 is changed to -OH or -SH the effects may be more desireable as medication. If R1- is NH2- a urea like compound is formed; 2(-NH2)s attached to (S(=O)2). With -OH and -SH the hyrogens would be acidic and alkyl groups would be easily replaced in acid conditoins. -NH-NH2 group might be better. R1 as benzene is popular. Cl-(S(=O)2)-R1 is Tosyl Chloride (used to make tosulates) if -R1 is toluene. R1 as Cl(3)- might work; being able to have inductive effects that "pull" electrons from Sulfur through the sigma bond. 38.184.1.101 (talk) 01:26, 9 October 2009 (UTC) Hisashi Bob Iwahashi