Talk:Sumatriptan

Structure image
The structure image of sumatriptan is as of 2006-07-29 wrong; the sulfonyl group (SO2) and its adjacent methylene group (CH2) should exchange positions. Example here: http://redpoll.pharmacy.ualberta.ca/drugbank/drugBank/PC_IMAGE/APRD00379_ZOOM.gif

Unfortunately, I don't have ChemDraw at hand to fix it.

Your link showing the 'correct' version is expired. The structural image may have been corrected since you posted this as, to me, the wiki article appears to show a correct structure after comparing it with an old research paper. --71.107.78.149 (talk) 22:54, 26 April 2009 (UTC)

actually no, but not for the reason mentioned above. the 3rd structure, which is the product of the hydrazine-imine formation with the 4-carbon cyano aldehyde. note: 4 carbon. the product that is displayed (the hydrazine imine) has 3 total carbons added to the structure (the imine carbon, the cyano-alpha carbon, and the cyano carbon). this implies the loss of carbon atom from the 4-carbon fragment added in this step. it is clear that the NEXT product (the indole) has the correct structure and number of carbons. This was obviously just a mistake, like we all make, and the author forgot to add a methylene. simple. nothing big. but absolutely true, nonetheless.128.111.146.194 (talk) 23:08, 30 March 2011 (UTC)

Side effects list
Do these symptoms arise directly after taking Sumatriptan, or do they develop over time? Blindness, for example is listed as a common side effect. Any drug that commonly causes blindness never would have made it to market! —Preceding unsigned comment added by 24.5.233.58 (talk) 20:13, 19 January 2011 (UTC)

Side Effects
AFAIK there are more known side effects. Among them the fact that frequent intake may cause migraine. —Preceding unsigned comment added by 87.58.145.180 (talk) 07:18, 5 June 2008 (UTC)

Any data on interaction with Alcohol?
Specifically blackouts, or increased susceptibility to Alcohols effects? —Preceding unsigned comment added by 69.227.188.109 (talk) 07:09, 21 July 2008 (UTC)

With reference to taking half a tablet - I am prescribed whole 50mg tablets to take when needed, but have found recently that a quarter of a tablet has an almost equivalent effect. These are miracle tablets - before I had them I was taking handfuls of paracetamol or aspirin to little effect. I've been prescribed them for almost 15 years now and couldn't have functioned without them. Migraines have lessened with age anyway, though, I think.

82.35.102.140 (talk) 12:43, 19 January 2009 (UTC)

Alcohol induced headaches are caused by the expansion of cranial blood vessels so alcohol would, in that sense, work against Sumatriptan, which works by contracting those blood vessels. It's possible that there is some other relationship with alcohol though, as I'm no expert on this drug. --71.107.78.149 (talk) 23:02, 26 April 2009 (UTC)

Cost of Imitrex in America
I saw on here that the cost is very low but I asked about the cost of 12 100mg tablets in Houston at Walmart and it would cost me without insurance $112. That's almost $10 per tablet... still HARDLY economical sense!!!!! There's got to be more economical means for migraines. —Preceding unsigned comment added by 99.148.254.245 (talk) 23:33, 7 April 2010 (UTC)

Merge from Imigran recovery
Is there any reason that imigran recovery shouldn't just be a subsection of sumatriptan? Does it warrant its own article? Ekips (talk) 04:47, 12 May 2010 (UTC)

I see no reason for there to be a separate imigran recovery page. It's the same chemical, same medication. Merge them. Jmcclare (talk) 17:15, 28 June 2010 (UTC)

There is no rational reason for a separate entry for "imigran Recovery". It should undoubtedly be merged into "Sumatriptan". Dai Dant (talk) 17:13, 11 October 2010 (UTC)

Chemistry
Are you sure about the use of Tintetrachloride (SnCl4) in the first step? I'd presume that it's rather SnCl2 that is used, since the Nitrosamine formed with HONO has to be reduced and not oxidized. —Preceding unsigned comment added by 92.206.179.28 (talk) 12:29, 21 November 2010 (UTC)

Approval and availability
Some forms (delivery methods, 4mg and 6mg subcutaneous injections) of sumatriptan succinate are unavailable. I have considered adding this to the "Approval and availability" section, however, the only sources I have on this are the pharmacies and pharmacists who I've tried to refill my prescriptions, I am unsure of how to handle the sourcing. The reason given is that it is on "indefinite backorder" - so far 3 pharmacists have stated it will not be available as an auto-injection (stat-dose pen) or self injection (single dose vials) in either brand name or generic forms. Only current stock would be available if someone has it. —Preceding unsigned comment added by 69.148.147.225 (talk) 17:15, 27 January 2011 (UTC)

Side Effects
I am deleting the list of side effects shown as it does not reflect the main side effects (Table 2. Treatment-Emergent Adverse Events Reported by at Least 2% of Patients in Controlled Migraine Trials) quoted in the reference, but a set of "frequencies of less commonly reported adverse clinical events" also listed in the reference. As such, it gives a totally misleading picture. Table 2 shows the frequency of the most common side effects in patients treated with Imitrex and the frequency of the same side effects in patients taking placebo. The "frequencies of less commonly reported adverse clinical events" data, however, "include events observed in open and uncontrolled studies" and therefore "the role of IMITREX Tablets in their causation cannot be reliably determined". Someone needs to do a proper job with this as the existing job does not even show the most common side effects detected in controlled trials. AussieBoy (talk) 11:35, 6 March 2011 (UTC)
 * I decided to summarise Table 2 from the reference myself. Now at least the article includes a proper summary of the most common side effects seen in controlled trials in comparison with placebo. AussieBoy (talk) 12:22, 6 March 2011 (UTC)

Tightness in the chest?
My regular doctor prescribed Imitrex to address migraines, and subsequently my neurologiest (different doctor) re-issued that prescription. The pharmacist gave me generic sumatriptan. Both doctors told me that the minor, more or less painless but quite noticeable sensation of tightness in my chest and the loss of cardiovascular "energy" when taking sumatriptan is "normal" and "typical" of sumatriptan. I'm not seeking personal help on this topic, but what both doctors independently told me does not line up with what I have read here on the "Side Effects" and I think this particular side effect should be expanded upon. — Preceding unsigned comment added by Stimpy77 (talk • contribs) 02:48, 20 July 2011 (UTC)

Availability without prescription in UK
Article states:
 * However, it can be bought over the counter in the UK in 50mg dosage if already prescribed for the patient

This isn't entirely accurate. I was recently supplied it by a pharmacist without a previous prescription. They have a questionnaire produced by the manufacturer with an overlay containing guidelines for when it should or should not be supplied, or when a referral to a doctor is necessary. I'd add this to the article, but I don't have a source for it. I imagine somebody who knows more than I do about pharmacy regulations in the UK could provide one quite easily though. 212.159.69.4 (talk) 10:09, 4 May 2012 (UTC)

link for footnote 15 is broken
97.86.236.127 (talk) 16:51, 2 September 2013 (UTC)

sc
"Bioavailability: 15% (by mouth) / 96% (sc)" - What does "sc" stand for? This should be explained in the article because it is not a commonly used abbreviation. — Preceding unsigned comment added by 83.30.116.86 (talk) 13:00, 26 May 2022 (UTC)
 * "Subcutaneous". Fixed now. TJRC (talk) 17:59, 26 May 2022 (UTC)

Legal Status - a derivative of DMT?
It says that sumatriptan is regulated as a narcotic in Russia as it is a derivative of DMT. I followed the reference which was in Russian. I translated the page but couldn’t find sumatriptan anywhere on the page linked, let alone DMT. Is anyone able to authenticate this information? Chidedneck (talk) 02:15, 31 May 2022 (UTC)

Drug interactions?
Please list drug interactions 2600:1700:C2C0:2C20:C07B:9F94:CE02:95BF (talk) 04:14, 25 November 2022 (UTC)

Wiki Education assignment: PHMD 2040 Service - Learning Fall 2023
— Assignment last updated by Steph143 (talk) 05:54, 3 May 2024 (UTC)

New Section
I will be adding a new section with information about drug interactions with sumatriptan as a subheading under adverse effects. The sources I used were DailyMed and The Medical Letter. Steph143 (talk) 19:33, 3 May 2024 (UTC)


 * I will also be reformatting the article to have "Pharmacology" as a heading, with "Mechanism of action" and "Pharmacokinetics" as subheadings. Steph143 (talk) 19:39, 3 May 2024 (UTC)