Talk:Synthase

=ATP synthase complex=

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Can anyone help me better understand the ATP synthase complex? I understand this is happening with the carrier protein across the cristea during cellular respiration, but any more details pertaining to the ATP synthase itself would be greatly appreciated. --Enigma 03:24, 2 February 2006 (UTC)

=Synthase vs. Synthetase= The difference between synthase and synthetase should be added; synthetase requires ATP
 * According to IUBMB Commission on enzyme nomenclature, EC 6 constitutes the following:

"Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 'Ligase' is commonly used for the common name, but, in a few cases, 'synthase' or 'carboxylase' is used. 'Synthetase' may be used in place of 'synthase' for enzymes in this class."

Synthases that do not require ATP hydrolysis catalyse the reverse of the lyase reaction, and belong in EC 4 and are not ligases. At one time this was clearly distinguished by the difference in name 'synthase' and 'synthetase', but too many exceptions have crept in to the literature.96.54.32.44 (talk) 19:34, 17 February 2011 (UTC)

"EC 4. Lyases

Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. The systematic name is formed according to 'substrate group-lyase'. In common names, expressions like decarboxylase, aldolase, etc. are used. 'Dehydratase' is used for those enzymes eliminating water. In cases where the reverse reaction is the more important, or the only one to be demonstrated, 'synthase' may be used in the name."96.54.32.44 (talk) 19:39, 17 February 2011 (UTC)

Lyases? Are some transferases?
Article on Fatty-acyl-CoA synthase says it is a transferase. Are some synthases classified then as transferases? This article on synthases implies all synthases are lyases. CrocodilesAreForWimps (talk) 19:16, 1 November 2012 (UTC)

Lyase or Hydrolase?
The statement "they belong to the group of ligases, with lyases catalysing the reverse reaction." seems an over-broad generalization, if not incorrect. The enzymes catalysing the back reactions to DNA and RNA ligases are hydrolases. What examples are there of lyases catalysing back reactions to ligases? Socialambulator (talk) 21:29, 9 May 2016 (UTC)