Talk:TAAR1

December 2011
I created a new, fully updated page for TAAR1 — Preceding unsigned comment added by Stevereichh (talk • contribs) 01:39, 3 December 2011 (UTC)

Firing rate
I recently read this article http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618978/ which talks about the role of TAAR1 in reducing the firing rate of the cell (at least for dopaminergic cells?). I hope someone has the time to give this topic some proper description (oddly the caption on the image near the bottom of the page mentions this briefly). I have my own hypotheses that TAAR1 may be a neuroprotective receptor, reducing the firing rate to stop more calcium from flowing into the cell, and reversing the flow of dopamine through the DAT to reduce oxidative stress in the cytoplasm. But this may be putting the cart before the horse. — Preceding unsigned comment added by 96.21.96.70 (talk) 17:48, 6 March 2014 (UTC)


 * I've updated the page from amphetamine's pharmacodynamics section.  Seppi  333  (Insert 2¢ &#124; Maintained) 01:33, 7 March 2014 (UTC)

Content/Reviews to add

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 Seppi  333  (Insert 2¢ &#124; Maintained) 22:11, 14 March 2014 (UTC)

Updated TAAR1 pharmacology + TAAR1 receptor interactions: DRD2, A2a, NMDAR
Worth adding in Amphetamine/TAAR1 and elsewhere.


 * TAAR1 pharmacology review published last month


 * Should probably add a sentence on TAAR1-adrenoceptor-A2a and TAAR1-DRD2 heteromers and their function/significance in Amphetamine for completeness


 * For TAAR1, PEA+other TAs, and isoprenaline - PEA+Isop pharmacodynamics update

— Seppi  333  (Insert 2¢) 04:58, 13 July 2015 (UTC)

Lots of error messages
I just noticed there's a lot of error messages showing up in the refs section. I noticed you recently adjusted the ref structure on the page, so I wasn't sure how you wanted to handle this, but it appears most of the errors involve the list-defined refs.  Seppi  333  (Insert 2¢) 22:37, 8 October 2015 (UTC)
 * Sorry, I didn't complete the job leaving behind duplicate citation templates. The duplicates have now been been removed. Boghog (talk) 06:18, 9 October 2015 (UTC)
 * No worries. ty.  Seppi  333  (Insert 2¢) 15:17, 9 October 2015 (UTC)

New TAAR1 review by Miller+Grandy


- update for this page, amph, meth, trace amine, addiction.  Seppi  333  (Insert 2¢) 22:28, 28 January 2016 (UTC)

Another new review to add


 Seppi  333  (Insert 2¢) 18:35, 29 January 2017 (UTC)
 * Other papers to consider as citations for new content:
 * (Jan 2017) Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior.
 * (Jan 2017) Thyronamines and Analogues - The Route from Rediscovery to Translational Research on Thyronergic Amines.
 * (Oct 2016) Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies.

Lead
I'm not sure what the issue with the current lead is, but deleting the vast majority of the lead isn't the correct way to address an issue with a statement.  Seppi  333  (Insert 2¢) 22:10, 5 November 2017 (UTC)
 * I'm open to revising the lead of this article; but, if we're going to delete statements that are cited by references, I'd need you to indicate what statements are of concern and why you think they need to be revised.  Seppi  333  (Insert 2¢) 22:50, 5 November 2017 (UTC)