Talk:TDI-11861

S or R configuration?
This article indicates that the stereochemical configuration of TDI-11861 is S. However, in the previous study that describes the medicinal chemistry efforts to develop TDI-11861 (Miller et al. 2022), the configuration is R. Should the structure be corrected? Zwitterion44 (talk) 22:38, 18 February 2023 (UTC)


 * I just copied the structure from Figure 1 of the Nature article, which is free full text. I don't have access to the J Med Chem paper. If there is a conflict between sources then it would be best to contact the authors and confirm which one is correct, obviously we need to get it right on here. edit: I have emailed them on the contact address from the J Med Chem paper and will await a response. Meodipt (talk) 01:23, 20 February 2023 (UTC)


 * They never replied, however I am inclined to agree that the original J Med Chem paper is likely to be the more reliable source in this instance, so I have changed the picture to the R enantiomer. Meodipt (talk) 01:45, 25 February 2023 (UTC)


 * David Huggins from TDI responded via email and confirmed that the correct enantiomer is R as per the J Med Chem paper. They will look at getting the Nat Comm paper corrected. Meodipt (talk) 22:04, 27 February 2023 (UTC)