Talk:Tardive dysphrenia

Dear
Dear colleagues of mine, psychiatrists/neurologists/pharmacologists/psychologists:

Comments, questions, positive criticisms posted here, as on private, will be welcome, for sure.

''Leopoldo Hugo Frota, MD Adjunct Professor of Psychiatry - Federal University of Rio de Janeiro, Brazil. Posted from Rio, May 31, 2006. leopoldo.frota@uol.com.br''

Rio, June the 5th, 2006.

Dear Fellows:

To be more historically accurate and making justice to the relevant role of the psychiatrist/psychoanalyst David V Forrest in the original formulation of the Tardive Dysphrenia construct by Fahn, I would like to call your attention to the inclusion of the name of Dr. Forrest, as well as the institutional afilliation of Dr. Stanley Fahn, on the last reedition, posted by me, OK? Best regards,

Leopoldo Hugo Frota, MD.

Cleanup
The reason I put the cleanup tag on this article was because it doesn't conform to the Manual of Style. Please read that over and then rewrite the article so that it doesn't look like a million monkeys at a million typewriters hammered it out. Thank you. Avalyn 05:38, 7 June 2006 (UTC)

Dear Avalyn (Mr/Mrs):

Thanks for your attention and goodwill. I must confess I am a begginer at Wikipedia and not very much profficient in the language still. My sentences sounds pretty longer, right? Brazilian/Portuguese-style, sorry. As soon as I can I intend to read carefully the manual and next time try to do my best. In the meantime however, I would really appreciate specific suggestions you may have. Here or on private (leopoldo.frota@uol.com.br), OK?

Cheers,

Leopoldo (Leo).

This article needs the addition of an intro paragraph that tells what Tardive dysphrenia is before it tells how it came to be identified. RJFJR 21:03, 9 June 2006 (UTC)

Dear RJFJR:

As an specialist, let me say there is not a general technical agreement about the research construct and clinical diagnosis of Tardive Dysphrenia, till now. On this way, it must be seen as tentative in nature only. We just intend to start an international debate on the potential new psychiatric diagnostic category over here, the Wikipedia. Nevertheless, we thing the diagnostic criteria we posted at the end of the wiki will be of help to the general public and the average reader of the Encyclopedia, at least in part and/or in some ways. I trully hope. I've also suggested a visit the new wiki "Dysphrenia" (link), that we posted alltogether. Hoping to be giving you any usefull additional information here, thanks a lot for your attention and enriching directions, OK?

Cheers,

Leo.

''Leopoldo Hugo Frota, MD Adjunct Professor of Psychiatry - Federal University of Rio de Janeiro

Avalyn & ZZuuzz, buddies of mine :-)

Thanks a lot! Best regards,

Leo.

I made quite a lot of changes with a non-medical audience in mind. The article is pretty good as is, but treatment of the disorder needs to be address. Since it's neuroleptic-induced, I presume the treatment is to take the patient off the medication, but I didn't want to presume. K e rowyn 04:29, 4 July 2006 (UTC)

Dear Kerowyn:

Thanks a lot. There it is. I hope to fulfill your suggestions/expectations.

Cheers,

Leo.

Thanks. I made a few more edits, again for a non-medical audience. The article looks good as it stands, so I'm closing the cleanup taskforce file. K e rowyn 05:55, 20 July 2006 (UTC)

Clozapine is a partial D2- agonist?
I think, that not clozapine, but its active metabolite norclozapine (NCZP, N-desmethylclozapine, 8-chloro-11-piperazin-1-yl-5H-dibenzo(b,e)(1,4)diazepine) is a partial D2- and D3- agonist, which is currently in development as potential antipsychotic (ACP-104 by ACADIA Pharm Inc.). But, in effect it is of little relevance, since NCZP is a major active metabolite of clozapine. Could similar potential benefits be awaited from quetiapine and N-desalkylquetiapine, or is it too early to make such conclusions? Quetiapine seems to be pharmacologically the closest antipsychotic to clozapine, in some regrads. What about aripiprazole?--Spiperon 10:07, 4 May 2007 (UTC)