Talk:Tert-Amyl alcohol

IUPAC name error
I was making a list of solvents, while I notice that here tert-amyl alcohol IUPAC name is reported as 2-Methylbutan-2-ol, while the correct name is 2-Methyl-2-butanol, which is reported as other name. 2-Methyl-2-butanol is the correct name because it reports the longest chain. Does anyone know how to change this in the table? — Preceding unsigned comment added by Faballi (talk • contribs) 09:59, 10 May 2023 (UTC)

Untitled
don't know how to add images but it's here: http://en.wikipedia.org/wiki/Image:Tert-pentyl-alcohol-2D-skeletal.png
 * I've added it in now. -- Ed (Edgar181) 19:02, 21 May 2008 (UTC)

GABAA
can anyone qualify what kind of GABAergics 2M2B is at http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5005 and explain that under #Pharmacology next to GABAergic? --David Hedlund (talk) 01:25, 28 February 2013 (UTC)

Alcohol dehydrogenases (ADH)
Is human alcohol dehydrogenases (ADH) involved in 2M2M metabolization? Humans catalyzes the oxidation of ethanol to acetaldehyde but 2M2B is a teritary alcohol which does not convert to aldehyde metabolites (like acetaldehyde). If 2M2B compete with ethanol, and methanol, then it might be useful for treatment of methanol poisoning. --David Hedlund (talk) 01:35, 28 February 2013 (UTC)

Discussion on a safer 'drinking alcohol' with less toxic side-effects.
Here it is discussed 2-methyl-2-butanol being potentially a more effective alcoholic beverage base than is ethanol for the purposes of inebriation/recreational use of alcohol. Nagelfar (talk) 22:50, 12 August 2010 (UTC)


 * It's use of course made within smaller doses, relatively with ethanol, as should be a heeded condition for safety I must too note. Yet the purpose for its use for interests sake I must stress as being more than a greatly increased efficiency at achieving the intoxicated altered state that drinking ethanol-type alcohols does produce. An example being these ethanol-alternatives' peculiar taste in contrast to ethanol, which may be considered as an innovation to serve the diversity of flavoring at base for alcoholic drinks which ethanol, having of course a standardizing colorization of what palate it maintains (since it being of one formation upon the taste buds), may stretch that what mixes can achieve or accomplish for the olfactory "taste-sense" spectrum by having such another strongly attenuating/overweening a fixed commonality for constituent-ingredient allotted to whichever combinations may be used for a decidedly more pronounced/widened variegation. The universal underpinning of ethanol as a taste to all alcoholic drinks being supplanted. The future of drink mixology, perhaps if evolution and progression as increase & flexibility rather than other factors be deciding/prevailing, is then the bar starting with anhydrous ethanol, andhydrous 2-methyl-2-butanol & et cetra and with a very minute amount then adding the pure grade of each aromatic molecular flavoring as a pure solution extract part to the construction of an end product. This would be integrating the use of scents and flavors, as by addition of molecular constants defining flavor and smell, the latter by aroma compound (the examples therein down below giving the actual molecular via atomic composition at that internal link). This gets to the level of molecular mixology and makes the causal nightclub foray of traditional crude approximation by raw hewn/hewed precursors as bulky composite source substances on hand into a fine science of spliced and highly specific concoctions; from "shaken or stirred?" to "solute or emulsified?" and beyond to a stage of accuracy in patrons consumption) Nagelfar (talk) 08:42, 20 March 2011 (UTC)
 * Apparently one imbibing 2-methyl-2-butanol in favor to ethanol would likely pass a breathalyzer as it is a tertiary alcohol (ethanol being a 1' by comparison) and it neither reduces chromate nor has the same IR signature as ethanol. 216.227.116.61 (talk) 16:50, 15 November 2011 (UTC)

Octonol:Water Partition Constant (log P)
I believe the log P value for 2-Methyl-2-butanol is incorrect in this article: The value reported here is 1.095 although no direct source or reference is given for this particular property.

Several other sources report this value as 0.89,

http://logkow.cisti.nrc.ca/logkow/display?OID=1207

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~O4XY4V:1:owpc

ScottHW (talk) 01:34, 13 July 2012 (UTC)

Not a treatment for methanol poisoning
The article states: "Methanol poisoning treatment TAA may be used instead of ethanol to treat methanol poisoning. Tertiary alcohols like TAA do not metabolise to aldehydes like primary alcohols such as methanol and ethanol.[18]"

Reference 18 says absolutely nothing about this. TAA will not tie up alcohol dehydrogenase and aldehyde oxidase, the two enzymes responsible for methanol's toxicity. Methanol is ultimately metabolized to formate, which causes blindness and in higher amounts, death. The reason for using ethanol in methanol poisoning is that it binds to the aforementioned enzymes more strongly than methanol (ethanol is the "preferred substrate"), slowing down methanol's metabolism and reducing formate levels below the toxic level. The kidneys ultimately excrete the formate.

PaulKrb (talk) 08:04, 15 February 2013 (UTC)
 * Sorry, I hadn't seen this edit note and was selectively restoring most things. Had just got to the note about it not being in the reference. Testem (talk) 22:52, 17 March 2013 (UTC)

Destructive deletion
(talk) you need to make incremental deletions with clear reasons for doing so, as clearly there is a conflict about what belongs on this page. If text is "first evidence on message boards was in 2002" then a link to a message board is entirely appropriate as a reference. It is completely unclear why the case reports have been removed. — Preceding unsigned comment added by Testem (talk • contribs) 23:13, 17 March 2013 (UTC)

TAA ingestion level
The previous entry stated that 2-4g is enough to cause unconsciousness. It is not, this is the [historically used] therapeutic dose. This made me seek out the source, and the source is written as "up to ten drinks, corresponding to an intake of 100 g of ethanol, to put an adult to sleep. But in higher alcohols such as tert-pentyl alcohol (tert-amyl alcohol, amylene hydrate). the hypnotic effect is more pronounced. This compound has therefore been used in doses between 2 and 4 g as a sleep inducing agent. However. the unpleasant odor and the action as local irritant have handicapped its acceptance.".

Ie, 2-4g is sufficient as a sleep aid. It generally requires ~3-4x as much for unconsciousness, but I have no source for that handy so I will not add that. Editable Wolf (talk) 04:20, 19 March 2024 (UTC)