Talk:Tetracyclic antidepressant

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Are tetracyclic antidepressants based on the same tetracycle as tetracycline? Iridium77 23:48, 16 Feb 2004 (UTC)


 * No. A quick glance in the Merck Index shows Maprotiline is structurally unrelated to tetracycline.  Mirtazepine is another tetracyclic antidepressant that is currently used.  ElBenevolente 00:29, 17 Feb 2004 (UTC)
 * As far as I'm aware Mirtazapine isn't a tetracyclic but falls into the 'novel' or 'atypical' group of antidepressants which also include venlafaxine, reboxetine and nefazodone. - Vaughan 09:29, 17 Feb 2004 (UTC)


 * Mirtazepine is a tetracyclic AD that is related to Mianserin. It is even acknowledged in the product labeling:  http://www.fda.gov/cder/foi/label/2002/20415S9lbl.pdf ElBenevolente 16:38, 17 Feb 2004 (UTC)

Regarding mianserin, should we really say "have been reported in the scientific literature but are not publicly available"? Anyone can walk into a respectable science library and read hundreds of peer-reviewed articles about mianserin. ElBenevolente 17:07, 17 Feb 2004 (UTC)


 * My bad wording I'm afraid. I meant the drug has been discussed in the scientific literature but the drug is not publically available for use as a medication. Interesting FDA info by the way. So, this article should mention Mirtazepine and should not suffer from my poor english! - Vaughan 17:26, 17 Feb 2004 (UTC)


 * I recall that mianserin was available in Europe in the past. I didn't look too hard, but I found this reference:  "Mianserin (‘Bolvidon’, ‘Norval’) was withdrawn from the UK market after the introduction of mirtazapine" http://www.rcpsych.ac.uk/publications/gaskell/samplechaps/usedrugs5Chap.pdf  It may still be available in other countries.ElBenevolente 18:12, 17 Feb 2004 (UTC)


 * I added a link to the article on Mirtazapine I wrote. I also deleted the "see also" links, as they were all linked to already in the article. I wasn't sure if I went too far on that one, though, so please add those back if you think they should be there. Defenestration 18:37, 18 Mar 2004 (UTC)

I'm not sure that Trazodone is a tetracyclic antidepressant. I'm not an expert by any means, but RxList, for example, specifically says that it's not: http://www.rxlist.com/cgi/generic/traz.htm. Mrfh2k5 00:15, 6 July 2006 (UTC)

Trazodone and Nefazodone don't belong to the group of tetracyclic antidepressants (http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00533.txt) I can't say exactly what group they belong to, I only got a book (sorry german "Medizinische Chemie", Steinhilber) that says they form a unique group called dual serotonerg antidepressants, but I didn't find any weblinks for this

Trazodone is most definitely NOT a tetracyclic AD according to the FDA: "Trazodone HCl is an antidepressant chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents".

setiptiline availability
According to this old, scanned advert for setiptiline, it seems setiptiline was once available. Archive where it was indicated that it was setipiline depicted in the advert is. Is it still available in Japan? 1992 isn't that long ago. Zaphraud 01:20, 4 August 2007 (UTC)

Amoxapine? Trazodone?
Coudl somebody point out, what portion of their chemical structure allows to classify these as tetracyclics? Amoxapine is tricyclic, trazodone bicyclic.--84.163.110.20 (talk) 16:35, 15 April 2008 (UTC)