Talk:Toll-like receptor 5

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Peer reviewers: Immcarle25.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 10:38, 17 January 2022 (UTC)

Relevant articles for renewing TLR5 information
Bibliography

Castaño-Rodríguez, N., Kaakoush, N.O., and Mitchell, H.M. (2014). Pattern-recognition receptors and gastric cancer. Front Immunol 5, 1–23.

Husseinzadeh, N., and Davenport, S.M. (2014). Gynecologic Oncology. Gynecologic Oncology 135, 359–363.

Kassem, A., Henning, P., Kindlund, B., Lindholm, C., and Lerner, U.H. (2015). TLR5, a novel mediator of innate immunity-induced osteoclastogenesis and bone loss. The FASEB Journal 29, 4449–4460.

Leifer, C.A., McConkey, C., Li, S., Chassaing, B., Gewirtz, A.T., and Ley, R.E. (2014). Immunology Letters. Immunology Letters 162, 3–9.

Lim, J.S., Nguyen, K.C.T., Han, J.M., Jang, I.-S., Fabian, C., and Cho, K.A. (2015). Direct Regulation of TLR5 Expression by Caveolin-1. Mol. Cells 38, 1111–1117.

Miao, E.A., Andersen-Nissen, E., Warren, S.E., and Aderem, A. (2007). TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol 29, 275–288.

Uematsu, S., and Akira, S. (2009). Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection. J. Gastroenterol. 44, 803–811. — Preceding unsigned comment added by Immcarle21 (talk • contribs) 20:21, 2 February 2016 (UTC)

New lead section
Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene.[1] It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria.[2] Recent studies have also shown that functioning of TLR5 is likely related to osteoclastogenesis an bone loss.[3] Abnormal TLR5 functioning is related to the onset of gastric, cervical, endometrial and ovarian cancers.[4][5]

Plans for further changes:

1. Expand on the regulation pathway of TLR5, especially how Cav-1 is shown recently to be directly regulating TLR5 activity

2. Expand on the clinical significance of TLR5. I will focus on the role of TLR5 in multiple types of cancers, including gastric, cervical, endometrial and ovarian cancers.

3. Add in the section discussing possible therapeutics development that targets TLR5 activity in inflammation or cancer

4. Add in the section discussing the interaction between gut microbiome and TLR5

Immcarle21 (talk) 23:41, 9 February 2016 (UTC)

Wiki Education assignment: Immunology
— Assignment last updated by Immune2inaccuracy (talk) 20:27, 21 April 2024 (UTC)