Talk:Transmembrane domain

Untitled
The transmembrane domain article begins right off with the subject "Transmembrane segment." => "Transmembrane segment usually denotes a single transmembrane alpha helix of a transmembrane protein, also known as an integral protein.[1] More broadly, a transmembrane segment is any three-dimensional protein structure which is thermodynamically stable in a membrane. This may be a single alpha helix, a transmembrane beta barrel, a beta-helix of gramicidin A, or any other structure. Transmembrane helices are usually about 20 amino acids in length." ~https://en.wikipedia.org/wiki/Transmembrane_domain

I want to know about the transmembrane domain, not what comprises a transmembrane segment: "...a single transmembrane alpha helix... ." I see the transmembrane domain as the 'space' between the inner and outer cell membrane boundaries of animal cells. Describe its function, the reason for its existence, ... and what it's comprised of. Dcburdi (talk) 21:01, 6 August 2016 (UTC)

Hi, I'm a student working on this article for a class project. I wanted to know is anyone else actively working on/monitoring this page? A few things I'd like to work on are explaining what a transmembrane protein is (starting off the article by practically defining it as a single transmembrane segment of a single alpha helix does not seem like a thorough explanation of the topic) as well as elaborating some of the functions transmembrane domains are thought to play in anchoring and sorting proteins. I'm very new to this so any advice will be appreciated. Dinoboy10 (talk) 04:32, 21 October 2021 (UTC)

I have added some substance to the introduction and created a new section discussing factors needed for transmembrane domain genesis and incorporation into the membrane citing a relatively recent review article. Let me know if there are questions or issues. Is this enough to remove the flag? Thanks!! Db03d (talk) 20:38, 7 December 2021 (UTC)

I added a section on the functions of transmembrane domains, as before there was no mention as to what a transmembrane domain does. I also deleted a sentence about the prevalence and function of integral membrane protein, as that seems like it would go on the page for integral membrane proteins. I think the new lead more explicitly defines what a transmembrane domain is, as well as explaining some of the unique characteristics of TMDs, and does not conflate a TMD with something that it is not. For example, the page used to start out with defining a TMD as a transmembrane segment of an alpha helix. While this is not wrong, the conformation is not what defines a TMD. Rather, it is the fact that it spans the membrane. The intro now better explains this. I added the section on functions so that it is clear what a TMD does. There used to not even be a mention about anchoring. I added a figure showing what anchoring looks like, I think that since anchoring is such a basic and fundamental function of TMDs a figure is nice to illustrate it. I also listed several other functions as well as referenced some articles that expound on additional roles TMDs have apart from anchoring. I also added a reference that more fully explains what TMDs are and do. I think that should be enough to remove the flag? It seems like there are plenty of references. Dinoboy10 (talk) 00:09, 12 December 2021 (UTC)

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 31 August 2021 and 16 December 2021. Further details are available on the course page. Student editor(s): Dinoboy10. Peer reviewers: EAGMIL, J dotter.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 09:36, 18 January 2022 (UTC)

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 24 August 2021 and 10 December 2021. Further details are available on the course page. Student editor(s): Db03d.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 09:36, 18 January 2022 (UTC)