Talk:Trazodone

note
This page is a mess. Information is scattered everywhere and is not grouped together properly. For example, information about interactions is also under the precautions section. Sections 4, 5 and 6 also all belong in one large section with subdivisions. I'll clean it up eventually. Fuzzform 04:43, 11 May 2006 (UTC)

Note that trazodone is not a tetracyclic chemical (four joined rings), rather it has several separate cyclic structures. To quote 'Trazodone is a triazolopyridine derivative, chemically and structurally unrelated to tricyclic and tetracyclic antidepressants' Gribskov 11:54, 14 October 2006 (UTC)

5-HT2C interactions
The article currently states trazodone is a 5-HT2C antagonist, but this source (http://jpet.aspetjournals.org/content/285/3/983.abstract) explicitly says trazadone is a potent 5-HT2C agonist. The current reference on Wikipedia says the opposite. What gives? Can anyone with biomedical training and access to medical databases balance out the hypotheses about 5-HT2C interactions? From what can be gathered from the brazilian and american PI sheets (virtually identical), some people experience a decrease in sex drive (which would be compatible with 5-HT2C agonism, if Wikipedia is to be trusted at all), while other, more rarely, experience an increase (which would be compatible with 5-HT2C antagonism. This needs fixing! --Dnavarro (talk) 13:38, 5 March 2010 (UTC)

Permanent Erection
Apparently this is a rare side effect that requires some sort of operation to correct, but it doesn't seem to be mentioned in this article. --Mista-X 21:30, 9 July 2007 (UTC)

The condition is called Priapism. -- 24.226.115.176 00:43, 9 August 2007 (UTC)


 * Indeed, it's mentioned on the paient information here "Some men have reported long-lasting and painful erections with trazodone hydrochloride. If this happens to you, it is important that you stop taking trazodone hydrochloride and tell your doctor immediately."  from the patient info from a Winthrop packet, ref MPE 67991 --SirXaph 04:53, 3 November 2007 (UTC)

Side Effects
"uncontrollable laughter, sex drive increase. (Trazodone is also known to cause a 'hangover effect' in patients prescribed the drug as a sleep aid: the 'Trazodone hangover' generally ceases with regular use after three or four days.)" What is the source of these side effects? They don't seem to be mentioned in any other list of side effects that I could find. The "hangover effect" is not a common phase found in patient information or medical related publications. "Temporary grogginess" may be a possibly suitable phrase, but I wouldn't suggest adding it without verifying its suitability from authoritative source. 24.226.115.176 00:43, 9 August 2007 (UTC)
 * I would describe it as a suitable phrase and can imagine being referred to as such by patients, however it's not an encyclopedic term. The description I have here says - "drowsiness - this should wear off as you continue to take the tablets," then "headache, dizziness, confusion, feeling less alert.." and also "nausea and vomiting" and "weakness".. (from Winthrop patient information leaflet - MPE 67991) all similar to the symptoms of hangover, but really it's not really appropriate to refer to it in this way.  Perhaps saying this way would be better:"Some of the more common side effects of taking Trazodone have been described by patients as feeling similar to a hangover, though these side effects often cease after regular use continues."
 * SirXaph 05:07, 3 November 2007 (UTC)

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mechanism of action - SRI?
From my psychopharmacology notes I have nefazodone and trazodone listed as SARIs = serotonergic antagonists and reuptake inhibitors. Is there more than that single citation to support the argument that they do not possess SRI activity? ("Trazodone is not a serotonin reuptake inhibitor"). If there is not significant corroboration, I will change this part to reflect controversy rather than simply stating it's not an SRI.--Xris0 (talk) 14:58, 1 May 2008 (UTC)

Trazodone Not an SRI
That a Trazodone metabolite (mCPP at a miniscule percentage) is an SRI doesn't seem to me to qualify Trazodone as an SRI, nor does it to experts in this field. Everyone around here (Wikipedia) likes quoting textbooks and op-ed articles. Search JOURNAL ARTICLES and find out what laboratory studies of these drugs have uncovered. Trazodone is, among other things, a 5HT-2A inhibitor at about 20 nM, making it, quite to the contrary, a good antidote to Serotonin Toxicity. Mirtazapine, its fellow weakling as an anti-depressant, was used in the Netherlands to reverse ST on this very basis. It takes not just run-of-the-mill overdoses, but rather mega doses of Trazodone to induce mild ST in rats (the symptoms in rats vary distinctly and in degree from those in humans). Case studies here and in not-particularly-well-refereed journals keep being cited about drugs including triptans and 1A-mediators causing ST, and everyone keeps accepting these assertions by non-experts (usually ER doctors or non-experts in ST) without batting an eye, and we end up wondering why we get: "Wikipedia entries on the costliest medical conditions contradicted the latest medical research 90% of the time" in a study in 2014. — Preceding unsigned comment added by Constantin Constantius (talk • contribs) 04:44, 25 May 2018 (UTC)

BetacommandBot 08:55, 27 October 2007 (UTC)

-Pharmacy Student: According to page 1128 of our "Pharmacotherapy: A Pathophysiologic Approach" text by DiPiro, trazodone *is* a serotonin reuptake inhibitor, as well as a 5HT2 receptor antagonist, and enhancer of 5-HT1A mediated neurotransmission. I believe the confusion arises due to the fact that the classification "SSRI" is an historical label rather than a serious scientific/pharmacological label. In other words, many other drugs that aren't called SSRIs by the medical community do in fact block SERT. Since nefazodone doesn't ever get called an SSRI in the real world, some may assume that it doesn't block SERT. The DiPiro text references the following when it lists the mechanisms of action for trazadone: Baldessarini RJ. Drugs and the treatment of psychiatric disorders: Depression and anxiety disorders. In: Hardman JG, Limbrid LE, Goodman A, et. al. eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill, 200:447-484". That's the "Goodman and Gilman" text, and both the DiPiro and G&G texts that I've listed here are the two biggie mainstays in pharmacy pedagogy, so I tend to trust them to the word.

-written on Nov 24, 2008

Physicians failing to give oral warnings
"Although such warnings may be included in printed materials supplied with the drug, physicians prescribing Trazodone, particularly those who are not psychiatrists, might not give oral warnings."

This is conjecture and needs to be cited or removed. For consistency, if this sentence is deemed acceptable, then similar phrasing should be added to every article about a prescription drug; surely any physician who is or is not a psychiatrist may make the mistake of not giving oral warnings for any drug. —Preceding unsigned comment added by 76.209.223.215 (talk) 05:33, 11 September 2008 (UTC)

Rare or common?
Nausea/vomiting are listed both as "most common" and under "rare - gastrointestinal." Neither are cited. Which is it? —Preceding unsigned comment added by 76.226.203.88 (talk) 20:38, 20 July 2010 (UTC)

Your patents and golf-playing do not interact with Trazodone. — Preceding unsigned comment added by Constantin Constantius (talk • contribs) 05:08, 29 May 2018 (UTC)

Side effects
How can "Drowsiness, fatigue, lethargy," be side effects of a sleeping pill? Quadzilla99 (talk) 10:21, 11 September 2010 (UTC)

It's an adverse reaction if you aren't taking it for sleep. 24.60.130.191 (talk) 01:35, 31 January 2011 (UTC)


 * And even if you ARE taking it for sleep, those effects last well into the following day, which is highly undesirable. Captain Quirk (talk) 22:01, 27 May 2014 (UTC)

re:how long
how long does trazadone useually stay in your system? — Preceding unsigned comment added by 24.63.38.137 (talk) 18:22, 18 October 2011 (UTC)

Confusing and misleading phrasing
In the section describing half-life: "if trazodone is taken at night..." What precisely constitutes night? 9pm? 3am? And would the described symptoms still be present the following day in both of these cases? — Preceding unsigned comment added by 99.246.101.22 (talk) 02:00, 16 February 2012 (UTC)

Alzheimers
We need reliable secondary sources. The BBC and a primary source are not OK. This is discussed in WP:MEDREV. Jytdog (talk) 17:36, 21 April 2017 (UTC) https://arstechnica.com/science/2017/04/drugs-already-in-medicine-cabinets-may-fight-dementia-early-data-suggests/ — Preceding unsigned comment added by 98.116.126.137 (talk) 23:21, 25 April 2017 (UTC)

Price incorrect / clarification?
The prices for UK and US are listed as e.g. '10 GBP per month'. Obviously it's not 10 pounds per month for the whole NHS, so this should be corrected to 10 GBP per patient, or £10M GBP per month, etc. I can't view the source otherwise would do it. — Preceding unsigned comment added by Mozboz (talk • contribs) 11:03, 12 March 2018 (UTC)

Kinetics
Article statement about elimination half life is contradicted, not supported, by the fact source the article statement cites. Article states "the first phase's half-life is 3 to 6 hours, and the following phase's half-life is 5 to 9 hours", citing Jauch R, Kopitar Z, Prox A, Zimmer A; Kopitar; Prox; Zimmer (1976). "[Pharmacokinetics and metabolism of trazodone in man (author's transl)]" [Pharmacokinetics and metabolism of trazodone in man (author's transl)]. Arzneimittelforschung (in German). 26 (11): 2084–9. PMID 1037253. (url https://www.ncbi.nlm.nih.gov/pubmed/1037253 ) But that source states "... with a half-life of 1 h for the earlier and 13 h for the second phase". Isn't this a contradiction per se? Is the wiki simply wrong?

Why has the half life source failed verification?
"	Trazodone IR: 7 hours[4] Trazodone ER: 10 hours[4]"

"Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013"

https://en.wikipedia.org/wiki/Trazodone#cite_note-DrugPoint-4

I have not been able to access "Truven Health Analytics, Inc. DrugPoint System" via search.--Disoff (talk) 15:13, 21 February 2020 (UTC)

Suggestion : Accentuate Effectiveness for Increasing Sleep and Downplay Effectiveness as Anti-Depressant
Clinical depression encompasses a wide range of different emotional disorders.

I recommend that a note be made that Trazadone only is effective for treating a sub-type of depression in which the patient sleeps less than 8 hours per night, or the patient has recently found themselves sleeping more than two hours less than the patient slept in the last two months, and the patient normally sleeps more than 8 hours.

Trazadone helps emotionally depressed patients only when the sub-type of depression includes sleep-loss or unusually small amounts of sleep, such as less than 8 hours of sleep in a 24-hour period of time. Muldoonsamuel55 (talk) 11:23, 1 February 2024 (UTC)

Wrong person remove me from your list.
Remove me from your list 2600:6C65:7FF0:7570:3DC4:41E0:FBCE:D363 (talk) 17:13, 26 June 2024 (UTC)