Talk:Trimethoprim/sulfamethoxazole

Other uses
I have had this medication prescribed for a parasitic infection (Cyclospora). I've also found it indicated for this purpose in a physician's handbook. Can anyone confirm this? --StarKruzr 17:44, 11 August 2006 (UTC)

Uses
This is a very British-centric article. In the US, IDSA recommends TMP/SMX as the first-line agent in uncomplicated UTI. - Emt147 Burninate!  07:01, 11 October 2006 (UTC)
 * By all means edit the article to reflect that? --Gak 10:50, 21 May 2007 (UTC)

i used to use it for acne
Me too! I've taken it twice a day for 5+ yrs now. I came here because I'm wondering if it's a bad thing for me to do, especially with Gilbert's Disease. If anyone wants to save my life, feel free to message me ;) ClintJCL (talk) 23:47, 28 October 2008 (UTC)

Dosage
How much is a safe dose? What constitutes an overdose? Is it taken once or twice daily? —Preceding unsigned comment added by 65.43.224.247 (talk • contribs) 00:17, 14 May 2007
 * Wikipedia dose not state dosages (see WP:MEDMOS) this being a matter to discuss with ones own physician. Like all drugs, it depends on the condition to be treated, body size, age and often if known liver or kidney disorders. David Ruben Talk 00:23, 14 May 2007 (UTC)

Safe dosages can be found from other sources. I don't see why wikipedia can't list typical mg:kg dosages for adults and children? —Preceding unsigned comment added by 67.171.29.187 (talk) 13:24, 1 June 2010 (UTC)

Bacteriocidal
Whether or not a drug is bacteriocidal or bacteriostatic depends on the organism. It often not possible to make a blanket statement about an antibiotic on this point. I suggest that this statement be removed. --Gak

Better source for information?
I'd like to add in the fact that in Canada co-trimoxazole is considered a first-line agent for skin and wound infections in patients who have a demonstrated true allergy to penicillin, but I can't find an online reference that isn't behind a paywall. Does anyone have one? -- Charlene 14:31, 17 July 2007 (UTC)

Question
When I was a child, my doctor had given me type of this medication, septra, for an ear infection. It resulted in an allergic reaction. Does this mean I have a type of SJS, Steven Johnson Syndrom? —Preceding unsigned comment added by 69.227.69.194 (talk) 06:21, 24 June 2008 (UTC)

I hanked the "weasel words" whining, because I can. Left the "citation needed" part though; should either be cited or taken down. —Preceding unsigned comment added by 70.61.22.110 (talk) 16:46, 11 September 2008 (UTC)

Is there any reason this page is the link being used by a lot of spam bots on forums? —Preceding unsigned comment added by 72.201.23.10 (talk) 18:47, 3 August 2009 (UTC)

Why is this page not called Trimethoprim-sulfa?
This is the term my pharmacopoeia uses and thus move here. Doc James (talk · contribs · email) 10:12, 8 November 2010 (UTC)

In the United States and Canada, the medication is referred to (generically) as an "SMT Combination". In fact, (as a Urologist) when writing a prescription, I usually write "SMT 400/80" for regular strength, or "SMT-DS" for the most often used "double strength" version. In thirty years of doing this, I have yet to receive a pharmacist call-back questioning the identity of the medication requested.

If I were to compose a wish list for this page, I would first address the high rate of allergic reaction to this medication, and the need to consume larger than normal quantities of fluids (preferably water) during the course of treatment. SMT Combinations are also useful in the treatment of sinusitis, acute/susceptible ear infections (not a choice for the initial course of treatment), and bronchitis.75.97.65.10 (talk) 23:35, 20 March 2011 (UTC)

Safe for long-term use?
I notice that erythromycin and teracycline are safe for long-term use in patents not allergic to them, but cephalexin is considered only for short term use. What about TPM-SMZ? -Reticuli 66.178.144.102 (talk) 21:20, 23 April 2011 (UTC)

Ototoxicity
Anyone aware of any research indicated it's ototoxic, like some other antibiotics? -Reticuli 66.178.144.102 (talk) 21:33, 23 April 2011 (UTC)
 * No. Antibiotic-related ototoxicity is mostly restricted to the aminoglycosides and, to a far lesser extent and for different reasons, the macrolides. The diuretic furosemide (a sulfonamide, as is sulfamethoxazole) can be ototoxic, but the effect has nothing to do with the sulfa structure. Fvasconcellos (t·c) 21:58, 23 April 2011 (UTC)

CSM Current Guidelines
The Committee on Safety of Medicines ceased to exist in 2005, so it can't have current guidelines. The Commission on Human Medicines may have the same current guidelines, but I don't know. I hope someone can dig out a relevant citation PRB (talk) 13:06, 17 July 2012 (UTC)

ANCA vasculitis
Co-trimoxazole is recommended for what used to be called Wegener granulomatosis limited to the upper respiratory tract, because of its favorable adverse effect profile compared to the other treatments. http://jama.jamanetwork.com/article.aspx?articleid=208292 JAMA. 2007;298(6):655-669. doi:10.1001/jama.298.6.655 --Nbauman (talk) 04:49, 14 February 2013 (UTC)

Front pic
Hi, people, I'm sorry if me changing the lead pic to two structural images causes any upset but I feel something more informative about the properties of the drug would be more helpful as a lead pic in the drugbox. Fuse809 (talk) 09:11, 7 January 2014 (UTC)

Breastfeeding
This source gives a better overview https://www.drugs.com/pregnancy/sulfamethoxazole-trimethoprim.html Specifically "LactMed: Use is considered acceptable when breastfeeding healthy, full-term infants after the newborn period; alternate agents are recommended in jaundiced, ill, stressed, or premature infants. Use should be avoided while breastfeeding glucose-6-phosphate dehydrogenase (G6PD)-deficient infants." Doc James (talk · contribs · email) 21:15, 21 November 2019 (UTC)


 * So how do you propose summarizing it? Doc James  (talk · contribs · email) 01:07, 22 November 2019 (UTC)

Article title
This article should be named Sulfamethoxazole/trimethoprim to match the order in the drugs.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f59d0c04-9c66-4d53-a0e1-cb55570deb62

https://www.ema.europa.eu/documents/psusa/sulfametrole/trimethoprim-sulfadiazine/trimethoprim-sulfamethoxazole/trimethoprim-co-trimoxazole-list-nationally-authorised-medicinal-products-psusa/00010593/201903_en.pdf

The WHO EML uses sulfamethoxazole + trimethoprim

Whywhenwhohow (talk) 03:36, 15 April 2020 (UTC)