Talk:Trimethylamine N-oxide

Better refs needed
Dear all, If somebody knwoledgeable in this field could find out good reference to replace [^ Hazen, Stanley. "New Research On Red Meat And Heart Disease". The Diane Rehm Show (Transcript). WAMU 88.5 American University Radio. Retrieved 10 April 2013.] that would be great. Without criticizing or challenging the persons participating in this talk themselves, this is "just" a radio interview transcript, and IMHO not of sufficient quality to be used as the single reference to support a complicated, comprehensive and potentially controversial statement such as "TMAO alters cholesterol metabolism in the intestines, in the liver, and in artery wall. In the presence of TMAO, there is increased deposition of cholesterol in, and decreased removal of cholesterol from, peripheral cells such as those in the artery wall." --MarmotteiNoZ 00:52, 15 April 2013 (UTC)
 * And a better source than the New York Times. NYT is a nice newspaper but seems like an weird source to support technical claims.  Folks are keen to edit, often without regard to their access or knowledge of sources.--Smokefoot (talk) 13:02, 25 April 2013 (UTC)
 * NYT's articles are usually based on an underlying journal article. That was true in my recent edits here. However, I did not look up the article in this case. That can be done. There are two journal articles one on red meat the other on eggs. User:Fred Bauder Talk 13:43, 25 April 2013 (UTC)
 * I have added the two underlying journal articles, one from Nature Medicine, the other from The New England Journal of Medicine. User:Fred Bauder Talk 11:39, 26 April 2013 (UTC)

Just a side note: in the health concerns section it lists phosphatidylcholine as present in some meats and eggs. This is misleading as it is one of the primary phospholipids found in the membranes of ALL biological cells. In food products it is most commonly extracted from eggs and soybeans (in the form of soy lecithin). Good source info would be source #1 from the phosphatdylcholine wiki. — Preceding unsigned comment added by 198.37.16.227 (talk) 14:48, 5 September 2013 (UTC)

Also implicated in chronic kidney disease
See http://www.eurekalert.org/pub_releases/2015-01/cc-gb012815.php I can't trace a proper reference to the original study and didn't want to add it without. 87.113.236.218 (talk) 15:27, 1 February 2015 (UTC)

Animal models
Hi, in the controversy section, a mouse study is used as a reference for this point: "The link between cardiovascular diseases and TMAO is disputed.[20]"

WP:MEDANIMAL says "the article text should avoid stating or implying that reported findings hold true in humans.", I believe by saying the link between CVD and TMAO is disputed while using a mouse study, breaks this rule.

It says, "Where in vitro and animal-model data are cited on Wikipedia, it should be clear to the reader that the data are pre-clinical,", so this needs to be reflected. RBut (talk) 08:35, 20 August 2021 (UTC)
 * I agree that animal models should be removed. This topic is a confusing one. There is a strong positive correlation between TMAO and fish intake and also TMAO circulations increasing heart disease risk but we have a lot of health outcome data on the Mediterranean diet high in fish which has shown oily fish decreases heart disease risk.
 * I just found these, which note that plant-based diets like Mediterranean diet and vegetarian are associated with decreased TMAO levels. It is suggested that dietary fibre and phytochemicals decrease TMAO. Psychologist Guy (talk) 00:05, 22 January 2024 (UTC)