Talk:Troparil

I hereby award this page, (-)-2β-Carbomethoxy-3β-phenyltropane, the prestigious Strangest Article Name Ever™ award. Congratulations. Picaroon 02:48, 21 April 2007 (UTC)

Its the name of the compound the page is about. Whats so strange about that? Meodipt 13:46, 24 April 2007 (UTC)

In the section on legality, with regard to how the difference between Cocaine and this compound is the same as the difference between GHB and ethanol: this isn't exactly correct. The point is still somewhat valid though. If you want to avoid a lot of ugly chemistry talk, skip the next paragraph.


 * begin chemistry rant*

Substitutional analogues, which were once the bread and butter of the "designer drug" chemist, now rendered illegal by a certain analogue drug act passed not too long ago, did indeed evade the law by *adding* functional groups, or making subtle alterations to the chemical structure, while maintaining an identical "backbone". This rather difficult to pronounce chemical is *NOT* made by taking cocaine and removing a functional group, at least if those molecule graphics are correct. For that matter, the functional group "removed" (a type of ester linkage) isn't even the same one as the one "removed" from GHB! In the case of GHB, you're removing a carboxilic acid group (which is, admittedly, similar to an ester group) AND youre also removing a carbon! (which would actually be difficult to do, carbon carbon bonds are tough to break) The moral of the story is that these two pairs of molecules have similar but different backbones.


 * end chemistry rant*

The point made that this molecule and cocaine might be too dissimilar to be considered analogues has some merit. It wouldn't hold up in court if it came down to it. In the end, the point is moot, because, too my knowledge the controlled substances analogue act specifically states that the drug must be similar in chemical structure and/or effect to an illegal drug. Its a stupid law though because its so vague. Caffeine has carbon, nitrogen and oxygen atoms too, and its also a stimulant, which could be argued to fit both of the requirements for that law. For more discussion on that law, see PIKHAL and TIHKAL by alexander shulgin. -an interested chemical engineer

Canada has been removed from the analogue*suspect countries as the Controlled Drugs and Substances Act does not mention analogue of cocaine merely :

"Coca (Erythroxylon), its preparations, derivatives, alkaloids and salts, including:

(1) Coca leaves

(2) Cocaine (benzoylmethylecgonine)

(3) Ecgonine (3–hydroxy–2–tropane carboxylic acid) " —Preceding unsigned comment added by JohnStuartMill (talk • contribs) 22:37, 3 February 2009 (UTC)

Capable of metabolism to something similar to ethylphenidate / cocaethylene?
Is there any note, source or study stating the existence or name of such a substance in the conversion of troparil with ethyl alcohol? The "trans-esterification" via carboxylesterase in vivo would presumably, due to the same structural attributes, do as it would to troparil the same as it does to methylphenidate & cocaine (that produces ethylphenidate / cocaethylene respectively) though I would not want to impose original research on to wikipedia of course, but if it is obscure yet attested to I think it would be a worthy addition due to its obscurity. (The same may similarly be true to less widely used cocaine analogues like Tropoxane, but whether they are attested to or not I am unaware, please let me know here.) Nagelfar (talk) 09:40, 16 September 2009 (UTC)

Removed content: methylphenidate overlap to troparil, etc.
The below was removed from a previous edit, though I still found some comparisons / information interesting enough as it stands to add here to the discussion page for reference:

...

Troparil is the only regular phenyltropane having a NET affinity that exceeds the DAT affinity.

Troparil is structurally similar to dexmethylphenidate. Indeed, it is possible to superimpose the structure of both these compounds to get very close overlap of the relevant pharmacophores. The reason why drugs like norcocaine and N-methyl ritalin are both weaker than the drugs from which they are derived still needs clarifying.

...

Nagelfar (talk) 11:55, 17 September 2009 (UTC)

DOI of ref 3 is dead
DOI of ref 3 (10.2165/00129784-200909030-00005) is dead but matches the one posted at Pubmed Bstard12 (talk) 21:46, 23 August 2012 (UTC)

Application
IT IS not soo rare, there are some reseach-chemical vendors who sell it quite cheap. 10g for 150€. So maybe the ethyl-ecgonine is Not that difficult to get. Excuse my poor writing from the Phone. 2A02:3037:418:D9F8:2:1:2998:5135 (talk) 15:28, 30 March 2022 (UTC)