Talk:Trousseau sign of malignancy

Pathophysiology: "incompletely understood" The pathophysiology is fairly well documented in UpToDate

Pathogenesis of the hypercoagulable state associated with malignancy "PATHOGENESIS — The pathogenesis of the hypercoagulable state of malignancy involves the interplay of multiple variables. As an example, intact tumor cells may express procoagulant activity that can directly induce thrombin generation; in addition, normal host tissues may express procoagulant activity in response to the tumor. Comorbid factors such as bed rest, infection, surgery, and drugs, may play a contributory role and may determine whether an asymptomatic increase in coagulability becomes manifest clinically [2] . (See "Drug-induced thrombosis and vascular disease in patients with malignancy" and see "Overview of the causes of venous thrombosis", section on Virchow's triad and section on Malignancy and see "Hypercoagulable disorders associated with malignancy").

Early reports noted that many tumors associated with thrombotic complications were mucin-secreting adenocarcinomas of the gastrointestinal tract [3,4]. However, many nonmucin-producing tumors are also associated with hypercoagulability and it has not been possible to purify a unique procoagulant moiety from mucin. The substances that have been isolated from animal and human tumors with procoagulant activity fall into two major categories: tissue factor-like procoagulant and cancer procoagulant [5]. (See "Hypercoagulable disorders associated with malignancy", section on Mucin)." (Excerpt used under fair use)

I do not personally understand this completely enough (yet) to re-write the section, but the information is definitely there.

Two things: 1. I would suggest to the poster above reading the UpToDate article (as cited) one more time. From my perspective, the article makes many postulations as to the cause of hypercoaguable states in malignancy but does not seem firm in its conjectures.

2. This wiki article suggests that Dr. Trousseau died from Pancreatic cancer and then subsequently says that he died from gastric carcinoma. A small point, but it needs cleared up. 204.152.156.1 (talk) 18:17, 2 February 2013 (UTC)Matt

According to Robbins (Pathologic Basis of Disease 8th Ed. page 903) Armand Trousseau's autopsy revealed pancreatic cancer. 204.152.156.1 (talk) 18:52, 2 February 2013 (UTC)Matt