Talk:Tuberculosis/Archive 2

External links modified
Hello fellow Wikipedians,

I have just modified 2 external links on Tuberculosis. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
 * Added archive https://web.archive.org/web/20100804052035/http://www.australianprescriber.com/magazine/33/1/12/18 to http://www.australianprescriber.com/magazine/33/1/12/18/
 * Added archive https://web.archive.org/web/20111001132818/http://www.microbelibrary.org/component/resource/laboratory-test/2870-acid-fast-stain-protocols to http://www.microbelibrary.org/component/resource/laboratory-test/2870-acid-fast-stain-protocols

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

Cheers.— InternetArchiveBot  (Report bug) 13:27, 2 August 2017 (UTC)

Semi-protected edit request on 1 November 2017
M. tuberculosis complex (MTBC) should be linked to https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_complex

GregMo72 (talk) 18:07, 1 November 2017 (UTC) GregMo72 (talk) 18:07, 1 November 2017 (UTC)
 * Yes check.svg Done Minor edit only, and appropriate. &mdash; KuyaBriBri Talk 18:24, 1 November 2017 (UTC)

Semi-protected edit request on 2 November 2017
On 27 May 2016, a change was made to remove the word 'usually' from the first sentence:"Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB)." This implies that Mycobacterium tuberculosis is the only causative agent which is clearly not the case as pointed out further down in the article. Specifically, under the heading of 'Causes', it is pointed out that M. bovis, M. africanum, M. canetti, and M. microti are also causative agents. This first sentence should be changed back to include 'usually' as it is more correct this way. GregMo72 (talk) 18:49, 2 November 2017 (UTC)
 * Yes check.svg Done as the proposed wording agrees with what is stated in the "Causes" section. &mdash; KuyaBriBri Talk 21:28, 2 November 2017 (UTC)

Semi-protected edit request on 8 December 2017
TB is now the number one infectious disease killer as it surpassed HIV/AIDS. I would like to change the article to reflect this. Asiroka gtb (talk) 16:14, 8 December 2017 (UTC) If you want to suggest a change, please request this in the form "Please replace XXX with YYY" or "Please add ZZZ between PPP and QQQ". Please also cite reliable sources to back up your request, without which no information should be added to, or changed in, any article. - Arjayay (talk) 17:36, 8 December 2017 (UTC)
 * ❌ This is not the right page to request additional user rights.

External links modified
Hello fellow Wikipedians,

I have just modified one external link on Tuberculosis. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
 * Added archive https://web.archive.org/web/20070705100742/http://www.hpa.org.uk/infections/topics_az/tb/menu.htm to http://www.hpa.org.uk/infections/topics_az/tb/menu.htm

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

Cheers.— InternetArchiveBot  (Report bug) 05:45, 22 December 2017 (UTC)

Semi-protected edit request on 25 April 2018
Request: minor change under "Pathogenesis".

Mycobacterium tuberculosis avoids phagocytic destruction not only by mechanical blockage of the reactive oxygen species through the mycolic acid capsule, but also (and most importantly) through inhibition of the formation of viable phagolysosomes. It's able to stop the fusion of a phagosome with a lysosome by several mechanisms, detailed here: https://www.sciencedirect.com/science/article/pii/S1931312808001546. Tuibiel (talk) 23:23, 25 April 2018 (UTC)


 * User:Tuibiel what wording do you propose we add? Doc James  (talk · contribs · email) 01:13, 26 April 2018 (UTC)
 * Red question icon with gradient background.svg Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Waddie96 (talk) 11:17, 26 April 2018 (UTC)

1/3 of population
1/3 of the world population is not infected with TB. They are in infected with latent TB. The cited source clearly says that. The info on the main page is misleading and wrong. The citation is number 1 on the references CarlKingSnake (talk) 03:08, 30 June 2018 (UTC)
 * Latent Tb is Tb... Doc James  (talk · contribs · email) 14:51, 2 July 2018 (UTC)

Cited article is not evidence it was present in the Americas in 100AD
The article cited in the history section references a study of 12 mummies which vary in age across about 1000 years. Only some of the mummies studied showed evidence of TB. This is not conclusive evidence for the claim that TB was in the Americas since a date as specific as 100AD. In fact, the detailed history article provides better evidence that TB arrived in the Americas via animal transmission (seals), and the exact date is not clear. I can't edit the page myself since I'm not confirmed or autoconfirmed yet. — Preceding unsigned comment added by Jegelstaff (talk • contribs) 22:10, 11 July 2018 (UTC)

Semi-Protected Edit Request on 23 July 2018
Request: Clarity Fix Under "Management"

Currently the section starts with a discussion of treatment using antibiotics and when discussing regimens states that "Latent TB treatment may employs one or two antibiotic." and "Active TB disease is best treated with combinations of several antibiotics to reduce the risk of the bacteria developing antibiotic resistance." I request that this is changed to one sentence: "Active and Latent TB are best treated with regimens of multiple antibiotics to reduce the risk of the bacteria developing antibiotic resistance." The three citations across the two sentences can be kept and added to the end of the combined sentence.

This fixes an awkward pair of sentences and fixes the misspellings of the latent TB sentence. Also, while the latent TB sentence suggests "one or two" antibiotics can be used, the Borisov paper cited in the latent sentence section suggests that 3HP (a multiple drug regimen) "is as safe and effective as other recommended LTBI regimens and achieves substantially higher treatment completion rates." so it would be safe to say that both Latent and Active TB are best treated with multiple antibiotics. SWL36 (talk) 18:32, 23 July 2018 (UTC)


 * SWL36, thank you for pointing out the grammatical errors and reminding us of the information in Borisov's paper.


 * Borisov's paper does indeed describe the CDC's increasingly broad range of people who are recommended to receive the 3HP regime. However the CDC is a US organization, and primarily aims to manage the health of US citizens.


 * Here is the WHO's 2018 guideline on latent tuberculosis. Page 23 states that six months of isoniazid continues to remain a recommended treatment. One new recommendation is the alternative use of 3HP in countries with high TB incidence. Axl ¤ [Talk] 13:52, 25 July 2018 (UTC)


 * I have adjusted the text and replaced the old reference with the current WHO 2018 reference. Axl ¤ [Talk] 14:06, 25 July 2018 (UTC)

Unnecessarily outdated reference
I do not have much experience editing Wikipedia, but I noticed that references 1 and 49 are to old, archived versions of the World Health Organization's TB Fact sheet when there is a much more recent (February, 2018) one available, and I am confused why. Is it just because someone has to go through the references and make sure that the current fact sheet still supports the claims that the old versions did? In particular, I noticed that the first sentence of the fourth paragraph of our article states that one in three people have TB, while the updated statement in the WHO fact sheet (third paragraph after the bullet points) is one in four. — TeragR disc./con. 04:58, 13 September 2018 (UTC)
 * Yes requires updating. Have done some. Doc James  (talk · contribs · email) 04:15, 15 September 2018 (UTC)

Vague Line About Consumption In Lead Paragraph

I appear to be blocked from editing on this library computer, but the line at the end of the first paragraph about consumption doesn't directly tell us that TB used to be called consumption. It assumes the reader knows that, which most readers do not. Anybody wanna change it? Tuberculosis specialist respiratory therapist — Preceding unsigned comment added by 64.126.160.178 (talk) 20:36, 10 October 2018 (UTC)
 * Thanks have adjusted Doc James  (talk · contribs · email) 01:12, 11 October 2018 (UTC)

Research: new technique
There seems to be one new technique that hasn't been mentioned at the research section and which could help to hinder development of the biofilm. See here. Perhaps it is interesting enough to add to the research section ? Genetics4good (talk) 08:01, 2 April 2019 (UTC)

merge from Epidemiology of tuberculosis
Epidemiology of tuberculosis has the same content (albeit updated) as in this article. I propose that article is merged with this one. — Preceding unsigned comment added by 88.115.204.102 (talk) 20:51, 28 September 2019 (UTC)

Broncholithiasis
Not currently mentioned, but broncholithiasis is a complication of TB 10.1016/j.chest.2019.05.012 JFW &#124; T@lk  15:15, 16 October 2019 (UTC)

Clunky/vague wording
Hello all, the sentence "Tuberculosis has been present in humans since ancient times.[14]" towards the beginning of the article feels clunky and vague. I believe a transition to a quantitative rather than qualitative fact would allow the reader to get a better understanding of tuberculosis's history and provide smoother reading.

DropBear42 (talk) 19:39, 26 November 2019 (UTC)DropBear42

"world's most deadly"
Does not IMO belong in the first sentence. It is more complicated than that and depends on the year. Pneumonia kills more people but pneumonia is not a single agent. Diarrhea often kills more but is not a single agent easier, though they are infectious diseases. Doc James (talk · contribs · email) 05:28, 27 April 2020 (UTC)



Semi-protected edit request (2020-05-31)
This page contains two inconsistent claims about TB's ranking as a global cause of death among infectious diseases. In the last paragraph of the opening section, the article states, "This makes it the number one cause of death from an infectious disease.[13]" On the other hand, the first sentence of the second paragraph in subsection 'Epidemiology' states, "Tuberculosis is the second-most common cause of death from infectious disease (after those due to HIV/AIDS).[9]" Citation #9 was published in 2010, whereas #13 was published by the WHO in 2017. The WHO currently claims TB is the "leading cause [of death] from a single infectious agent (above HIV/AIDS)".

For this reason, I ask that you please change "Tuberculosis is the second-most common cause of death from infectious disease (after those due to HIV/AIDS).[9]" in subsection 'Epidemiology' to "In 2018, tuberculosis was the leading cause of death worldwide from a single infectious agent. "

Nathanmcnulty (talk) 06:10, 31 May 2020 (UTC)
 * Yes check.svg Done. Thank you  for the clear and valuable request. Adrian J. Hunter(talk•contribs) 09:05, 31 May 2020 (UTC)

Semi-protected edit request on 14 June 2020
Gaey i ded in tb 80.217.18.170 (talk) 16:30, 14 June 2020 (UTC)
 * Red question icon with gradient background.svg Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Pupsterlove02  talk • contribs 16:43, 14 June 2020 (UTC)

Semi-protected edit request on 16 August 2020
Please place after the sentence "By 1918, TB still caused one in six deaths in France." The source doesn't say anything about 1918, and the only reference to France is a passing comment on page 413 about some experts recommending that tuberculosis patients go to Menton and Cannes. 2601:5C6:8081:35C0:3916:B2DD:3460:75B3 (talk) 22:23, 16 August 2020 (UTC)
 * I thought that the requested provided a good description of requested improvement (flagging a missing citation) and page #s so I added the citation needed template. Thanks. JenOttawa (talk) 23:05, 16 August 2020 (UTC)

Updates on the WHO Website
Because the website of the World Health Organization (WHO) updated their Tuberculosis website as of 14 October 2020, one of their updates was the key facts about the deaths dropping from 1.5 million (2018) to 1.4 million (2019).

Can anyone please update the article by adding the new infos, thank you.

Frozenimpact (talk) 20:47, 17 October 2020 (UTC)

The lack of "Extrapulmonary Manifestations of Tuberculosis" as a HUGE section or article is just a shame
I'm not exactly volunteering to write it, and it is alluded to in the lede section and miliary tuberculosis is very briefly covered in the "pathogenesis" section (and possibly a bit misleadingly covered, but it is so brief that I won't complain). The range and fascinatingness of extrapulmonary manifestations of tuberculosis infection is just staggering. The tubercles or lesions or granulomas found outside the lungs are not necessarily small, and they have a wide range of effects. They can also be mistaken for cancer or other problems after medical imaging. Also sadly missing is a mention of WHY antibiotic therapy for tuberculosis needs to be so long: It is because the sheer size of the lesions means that killing the entire thing, all the way to the center, can take multiple months. The antibiotic does not penetrate especially deep, so it rapidly kills the bacteria that are alive and metabolically active and might be expelled in sputum (from the outermost surface), and the person becomes non-contagious, but actually clearing the infection requires continuous antibiotic therapy until you have killed layer after layer of bacteria-laden dead-or-metabolically-inactive lesion center material. That was two topics, both extrapulmonary manifestations of tuberculosis infection and also why tuberculosis therapy takes multiple months, and I don't have readily available citations. I actually didn't read the treatment section, it may already mention the reason for such prolonged courses of antibiotic therapy. But extrapulmonary manifestations are definitely only barely covered, they are also mentioned in one of the images. Those are two suggestions. 209.94.144.13 (talk) 06:00, 29 April 2021 (UTC)


 * Note: the topic is addressed in greater detail in Extrapulmonary tuberculosis, Miliary tuberculosis, and articles covering TB infection in particular organs. It might be wiser to expand these articles instead of adding such details on the Tuberculosis page which offers a general overview of the topic and may become congested.


 * Kind regards, -J Jay Hodec (talk) 22:28, 29 April 2021 (UTC)

Semi-protected edit request on 3 October 2021
I spotted a grammatical error. Here is it: In second paragraph the first sentence states as follows: 'Tuberculosis is spread from one person to the next through the air when people who have active TB in their lungs cough, spit, speak, or sneeze.' But instead of it, the sentence should be 'Tuberculosis spreads from one person to the next through the air when people who have active TB in their lungs cough, spit, speak, or sneeze.' Please Consider this Anan 265 (talk) 09:13, 3 October 2021 (UTC)
 * Red information icon with gradient background.svg Not done: Passive voice is not a grammatical error RandomCanadian (talk / contribs) 02:00, 4 October 2021 (UTC)

Semi-protected edit request on 16 October 2021
Please link Tuberculosis elimination in the opening paragraph of the "Public health" section: "Public health campaigns which have focused on overcrowding, public spitting and regular sanitation (including hand washing) during the 1800s helped to either interrupt or slow spread which when combined with contact tracing, isolation and treatment helped to dramatically curb the transmission of both tuberculosis and other airborne diseases which led to the elimination of tuberculosis as a major public health issue in most developed economies."

Thanks, 2A01:4C8:58:C7F5:35E6:7AAC:98C4:6551 (talk) 06:20, 16 October 2021 (UTC)
 * ✅ Thanks IP! (t · c)  buidhe  06:54, 16 October 2021 (UTC)

Should the lead mention poverty?
Both historically and present the disease is associated with poverty and poor living conditions (and now) ability to treat it in wealthy countries. This seems more important than exact percentages for various countries and regions in 2018. (t · c)  buidhe  22:59, 16 October 2021 (UTC)

Ujk
Yuu7 103.166.244.220 (talk) 09:36, 11 February 2022 (UTC)

Semi-protected edit request on 2 August 2022
change "eight countries" to "seven countries" in the fourth paragraph of the introduction, as only 7 countries are listed: India, China, Indonesia, the Phillipines, Pakistan, Nigeria & Bangladesh. Emadkhan713 (talk) 04:45, 2 August 2022 (UTC)
 * ✅ PlanetJuice (talk • contribs) 19:07, 2 August 2022 (UTC)

Link this page with Polish "gruźlica człowieka" equivalent
A Wikipedia page exists for the same term "tuberculosis" in Polish language already as "gruźlica człowieka", but the link to it in the language tab is missing. Please, connect them, if you know how to do so. 2A04:4A43:55CF:CEEF:0:0:9C3:3917 (talk) 21:52, 26 September 2022 (UTC)

Semi-protected edit request: Cultural references
Add a brief sentence about the videogame Red Dead Redemption 2, where the main character contracts the disease and this event plays a major role in the development of the game. Example (from its corresponding Wikipedia article):

Tuberculosis plays a major role in the 2018 western video game Red Dead Redemption 2. In the game, protagonist Arthur Morgan contracts the disease after an altercation with a diseased farmer, giving him only a short time to live following his diagnosis, changing his view of the world and making him reflect on what he wants to do with the time he has left. 79.116.183.145 (talk) 07:47, 29 May 2023 (UTC)

Semi-protected edit request on 20 September 2023
116.204.230.25 (talk) 13:32, 20 September 2023 (UTC)
 * Red question icon with gradient background.svg Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate.  ULPS ( talk •  contribs ) 14:37, 20 September 2023 (UTC)

Semi-protected edit request on 13 January 2024
change "second leading" to "second-leading" (compound adjective describing cause of death should be hyphenated) HyperCube03 (talk) 11:19, 13 January 2024 (UTC)
 * While I can't actually point to any kind of grammatical rule stating otherwise, this seems intuitively wrong to me. I am also entirely unable to find even a single instance of "second-leading" in any source at all. I'll leave this open so that there are more eyes here but this seems a bizarre hyphenation at first glance. I would completely agree for "second-biggest pencil in the box", "second-most watched movie of all time", etc., so I'm not sure why "second-leading cause of death" looks so wrong, though. Tollens (talk) 11:56, 13 January 2024 (UTC)
 * Not an expert in grammar, but I suspect the apparent "wrongness" of this hyphenation might stem from the common usage of "leading cause of death", which makes it seem like a permanent noun phrase. Perhaps using something like "second-most common" would sound more natural. Liu1126 (talk) 15:29, 13 January 2024 (UTC)
 * Red information icon with gradient background.svg Not done for now: please establish a consensus for this alteration before using the template. M.Bitton (talk) 19:23, 14 January 2024 (UTC)

Semi-protected edit request: Adding new information on Bedaquiline
Right now the article says this on the use of Bedaquiline to tread MRD TB:


 * A number of medications are being studied as of 2012 for multidrug-resistant tuberculosis, including bedaquiline and delamanid. Bedaquiline received U.S. Food and Drug Administration (FDA) approval in late 2012. The safety and effectiveness of these new agents are uncertain as of 2012, because they are based on the results of relatively small studies. However, existing data suggest that patients taking bedaquiline in addition to standard TB therapy are five times more likely to die than those without the new drug, which has resulted in medical journal articles raising health policy questions about why the FDA approved the drug and whether financial ties to the company making bedaquiline influenced physicians' support for its use.

The information about the risks comes from 2012, and if thus very old. I request this be updated using the source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478224, which is an analysis of larger groups from 5 countries which shows that bedaquiline significantly improves health outcomes. Perhaps the paragraph could be reshaped to this:


 * In 2012 a new medication regimen was approved in the US for multidrug-resistant tuberculosis, using bedaquiline as well as existing drugs. There were initial concerns about the safety of this drug (put the sources currently used here), but later research on larger groups found that this regimen improved health outcomes (source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478224). By 2017 the drug was used in at least 89 countries (source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529252/).
 * Another new drug is delamanid, which was first approved by the European Medicines Agency in 2013 to be used in multidrug-resistant tuberculosis patients(source: https://web.archive.org/web/20131203022613/http://www.ema.europa.eu/ema/index.jsp?curl=pages%2Fnews_and_events%2Fnews%2F2013%2F11%2Fnews_detail_001972.jsp&mid=WC0b01ac058004d5c1), and by 2017 was used in at least 54 countries (source:source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529252/).

(I'm sorry I don't know how to format the sources on the talk page to make it easy to copy paste them into the real article)

I think this change will help the article fit a more up to date view on tuberculosis treatment Superstrijder (talk) 11:45, 20 March 2024 (UTC)


 * ✅  Antrotherkus 19:40, 9 April 2024 (UTC)

Semi-protected edit request: Misplaced comma
In the section "Treatment," under the subheading "New onset," there is a misplaced comma in one sentence. It reads "However recently, results from an international, randomized, controlled clinical trial indicate that [...]." Please change this to, "However, recently results from [...]," or, if consensus favors it, "However, recently, results from [...]," or even, "Recently, however, [...]." Chwijwi (talk) 01:44, 5 June 2024 (UTC)
 * ✅ Removed "recently" as outdated. Hyphenation Expert (talk) 09:53, 5 June 2024 (UTC)