Talk:V(D)J recombination

Number of VH genes
This article claims 39 functional VH genes, and a total of 123 VH genes. However, claims 51 functional VH genes.
 * Immunology is a new field and new genes are being discovered all the time. So you should generally go with the most recent article. Both these numbers are probably outdated by now, seeing as they are from 1995 and 1998. Elbonia (talk) 20:27, 8 September 2010 (UTC)

This history might also be interesting for this article. WhatamIdoing (talk) 02:49, 4 May 2008 (UTC)

The antibody repertoire is definitely much larger than 10530, you don't multiply them together, combinations are made from them and as a consequence 10^8 combinations are made, at least. —Preceding unsigned comment added by Rambatino (talk • contribs) 20:42, 29 April 2011 (UTC)

"Nearly Randomly"
In the intro:

V(D)J recombination nearly randomly combines Variable, Diverse, and Joining gene segments...

Sounds strange. Is this process really random? 184.153.187.119 (talk) 00:52, 7 February 2013 (UTC)

Assessment comment
Substituted at 09:45, 30 April 2016 (UTC)

Careful use of terms
The Background section contains this sentence: "The light chains also possess 2 Constant (Cμ and Cδ) gene segments and numerous V and J gene segments..."

Should this not read "The light chain LOCI..." or perhaps "The genes for the light chains..."? I would think that not only would the LC's not "have numerous V gene segments", but would not have ANY 'gene segments', only sequences encoded by the genes.

It may be obvious to the author, but I'm here because I'm completely naïve and would like to understand it.Captain Puget (talk) 19:40, 23 May 2016 (UTC)