Talk:Vincristine

Heading
Some issues you may want to expand on. Vincristine is a vinca alkaloid, of which other related agents include vinblastine and vinorelbin Vincristine is a neurotoxin. This is the main reason for the peripheral neuropathy (of which symptoms may included parathesia and altered motor skills). Constipation is a result of autonomic nervous system dysfunction as a result of the neurotoxic effect of vincristine. Most cancer therapies that include vincristine as an antineoplastic agent are generally limited to 2mg in a single IV dose, due to vincristine's neurotoxic properties. Vincristine is a vesicant. Care must be taken to avoid contact with the skin and tissues due to the burn and necrosis associated with contact in this manner. Care must be taken during the administration of vincristine to avoid extravasation. - Pharmer


 * sofixit. You're the pharmacist! JFW | T@lk  21:33, 11 October 2005 (UTC)


 * Actually, I'm just a pharmacy student. With the study load and exams, I don't really have the time to learn wiki markup let alone update this wiki in the kind of detail that I would like. I just thought that by commenting, it would be a quick way of raising some points that I felt were relevent to the topic, and which should be included and expanded upon in some form (possibly by someone with more time!). - Pharmer

C'mon, Wikimarkup is not hard! Just enclose a link with two brackets. That's it! JFW | T@lk  08:52, 14 October 2005 (UTC)

Chuck Schuldiner's resulting death
Don't you think that something should be included on how it poisoned and killer Chuck Schuldiner? Maybe it was the glioma not the chemo?

Structure is incorrect
The structure of this molecule is incorrect as shown. The molecule displayed in the PubChem link is correct. I would be happy to provide an updated image file, but am not sure how... any help?

C. Goodman

Contamination scandal in China
JFW, I favor reincluding the contamination scandal, as this did receive a fair amount of publicity and other people may come to this article in search of this story or at least for context. Andrew73 (talk) 14:37, 1 February 2008 (UTC)


 * OK, I have moved it to the relevant section and rephrased it slightly, also mentioning the production company's name. JFW | T@lk  15:03, 1 February 2008 (UTC)
 * Ah, I didn't see that section. Andrew73 (talk) 15:15, 1 February 2008 (UTC)

Not just childhood leukemia
My son was just diagnosed with Juvenile pilocytic astrocytoma in his Hypothalamus. He will begin Chemotherapy with carboplatin and vincristine through a Central Line. His oncologist, Dr. Lamkin of OHSU, suggested this treatment. I haven't done much Wikipedia editing, so I didn't want to change the main page.

--- August 8th, 2009 Elizabeth —Preceding undated comment added 20:26, 1 August 2009 (UTC).

minor edit and question
March 2, 2010 I suspect "action" in second paragraph should be "actin". Will change on confirmation if someone doesn't change it first. Will update external link to http://www.macmillan.org.uk/Cancerinformation/Cancertreatment/Treatmenttypes/Chemotherapy/Individualdrugs/Vincristine.aspx. —Preceding unsigned comment added by Twbeals31 (talk • contribs) 20:44, 2 March 2010 (UTC)

DrugBox cosmetic edit
I made cosmetic changed to the drugbox, as it was taking up the entire screen to display (my resolution is at 1280 x 1024). As I haven't edited drug boxes before, I didn't change the chemical forumla or change any of the text, only added line breaks to move the drug box down in size. Let me know if it's not right, also feel free to change it. KoshVorlon Naluboutes ''AeriaGloris 20:11, 30 May 2011 (UTC)

Vincristine isolation- suggested minor edits
I suspect that the aluminum oxide was the stationery phase for chromatography, and that trichloromethane and benzdichlormethane were the solvents (mobile phase) for eluting the vincristine from the column. If true (I do not have access to the original reference (#4)), a rewording would be "This fraction was further separated by chromatography on aluminum oxide, using trichloromethane and benzdichloromethane as eluents, and separation by pH to yield vincristine." Drbillellis 13:55, 4 July 2011 (UTC) — Preceding unsigned comment added by Drbillellis (talk • contribs)

Pronunciation of Oncovin - strange transcription
The current phonemic transcription  looks wrong (~ anchor?) (and doesnt match the ref) - surely it should be   (like (b)onk) to match  ? - Rod57 (talk) 13:27, 17 November 2015 (UTC)

Should the article mention a current shortage?
I've added a very short section on the impending shortage of this drug, mentioned in today's NYTimes. It seems (to me) very important for readers to know about this, in case they are reading the article because of a relative who needs it for childhood cancer, which I'm guessing probably motivates a lot of readers to read this Wikipedia entry. Does this violate WP:Notnews? I'm seeing "...including information on recent developments is sometimes appropriate,...", so maybe it's OK to include this. But if I'm wrong, by all means feel free to smack me down on this. Maybe rephrase in very-recent-history form? HandsomeMrToad (talk) 08:33, 15 October 2019 (UTC)

Baby versus fetus
Using "baby" is fine in this context as the medication causes birth defects in newborns. Doc James (talk · contribs · email) 07:32, 12 May 2020 (UTC)