Talk:Werner syndrome helicase

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Some text in this article was taken from http://ghr.nlm.nih.gov/gene=wrn (public domain)

Someone should render PDBID 3AAF (RQC domain of WRN protein bound to DNA) rather than this rather uninformative structure that was uploaded by its own creator.

150.212.110.182 (talk) 20:29, 15 March 2010 (UTC)

Comments from Iamwillthinnes
I think that it would be helpful to have a link to the WRN gene on the main page of Werner syndrome. — Preceding unsigned comment added by Iamwillthinnes (talk • contribs) 15:28, 20 March 2014 (UTC)
 * Added link, thanks! RegOH (talk) 00:43, 16 April 2014 (UTC)

I think that the opening paragraph, in which you describe a helicase and its function, may be better used as a first paragraph in the body of the article. Iamwillthinnes (talk) 15:31, 20 March 2014 (UTC)

The second sentence of the first body paragraph has awkward wording, I think that it could be phrased better. Iamwillthinnes (talk) 15:35, 20 March 2014 (UTC)
 * reworded, hopefully more clear now. RegOH (talk) 00:43, 16 April 2014 (UTC)

Comments from Akhan50699

 * It might be helpful to expand the "interactions" section if possible-- How do the interactions take place? What are the effects of these interactions?
 * left "interactions" at the end as a list for readers to observe at a glance, but added more detailed information about more important interactions in "Structure and Function" section. RegOH (talk) 00:46, 16 April 2014 (UTC)

Akhan50699 (talk) 03:33, 25 March 2014 (UTC)
 * The formatting of the references at the end is odd--Is there a problem with the formatting that you can fix?
 * I think the references look normal now, it's possible that there was an issue earlier with formatting that someone else fixed. RegOH (talk) 00:46, 16 April 2014 (UTC)

Structure and Function

 * The third sentence is awkward, consider revising it, moving it elsewhere, or removing it (it seems redundant considering the sentences following — perhaps combine it with the previous sentence?).
 * It was awkward. I removed it. Thanks. RegOH (talk) 15:07, 10 May 2014 (UTC)

Clinical Significance

 * Consider moving the sentence talking about the normal function of the Werner protein to the beginning of the paragraph. I think this would help people better understand the effects of mutations in this gene if they know what the normal function of the non-mutated protein is.
 * Thank you for the input. RegOH (talk) 15:10, 10 May 2014 (UTC)

Comments from Mjurgens369

 * You might want to consider adding links to areas like base-excision repair or nonhomologous end joining in the function section.
 * added the links, thanks. RegOH (talk) 15:17, 10 May 2014 (UTC)


 * I made some minor grammatical changes, and if any of the changes seem wrong to you, you can just change them back.
 * thank you. RegOH (talk) 15:17, 10 May 2014 (UTC)


 * It almost seems like the post-translational modifications section could fit under structure and function.
 * made post-translational modifications a subsection of structure and function. RegOH (talk) 15:17, 10 May 2014 (UTC)


 * I know other articles don't always do this, but if you want, you can expand the interactions section to include more specifics on each interaction. — Preceding unsigned comment added by Mjurgens369 (talk • contribs) 22:51, 26 April 2014 (UTC)
 * Other articles about enzymes, genes, etc, have a similar interaction section. Leaving it as is for now. Thank you. RegOH (talk) 15:17, 10 May 2014 (UTC)

Comments from Rraju2 for Final contribution

 * I think you may benefit from adding a few more wikilinks. Such as tetrameric, hexameric, catalytic. There may not be articles with those titles, but you can link it to something that explains it a little more.
 * You can also change the class of your article to a C on the quality scale since you added more information. You would just have to go the the template on top and change to Class=C. Im sure you can do something to fill in the  genetics template as well.Rraju2 (talk) 16:49, 10 May 2014 (UTC)