Talk:Wortmannin

MAPK and wortmannin
Not sure if this is true. Is MAPK inhibited by Wortmannin? It's not a commonly described target of wortmannin. What concentration is required to inhibit MAPK? Jagowins 17:47, 19 January 2006 (UTC)

Why not? read this: Adv Exp Med Biol. 1996;416:321-6. PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. Ferby I, Waga I, Kume K, Sakanaka C, Shimizu T.

AbuAmir 12:25, 30 April 2006 (UTC)

Maybe it would be a good idea for *someone* to put that reference in the article where the claim is made... Aaadddaaammm 09:12, 4 September 2006 (UTC)

I'm almost positive that Wortmannin has a longer half-life than 10 minutes. In the lab I work for, we use it in cell culture for 48-hour treatments and still see its effect as an inhibitor. Someone might want to reevaluate that tid-bit on the page describing Wortmannin.

10 minutes or more, it is enough to disqualify it as a drug, but if you can find a stable derivate, you have done it ! and, there already are stable semisynthetics of that ! AbuAmir (talk) 20:07, 19 November 2008 (UTC)

Specific Inhibitor
I would argue that since Wortmannin inhibits : "mTOR, DNA-PK, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations as well as members of the polo-like kinase family with IC50 in the same range as for PI3K." I will change this in a couple of days if no-one has any objections. ImmunolPhD 08:19, 26 July 2007 (UTC)

Someone with more experience than I have adding references please add the following abstract as a citation confirming the 8-13 minute half-life. http://www.ncbi.nlm.nih.gov/pubmed/14622954 — Preceding unsigned comment added by 138.16.64.88 (talk) 00:14, 26 June 2013 (UTC)

Wortmannin derivates going preclinicals
Please comrades, add a section about that. AbuAmir (talk) 12:10, 15 April 2008 (UTC)

Wortmannin has also been isolated from Fusarium oxysporum. Isolation and purification of a hemorrhagic factor (wortmannin) from Fusarium oxysporum (N17B) Abbas, H.K., Mirocha, C.J. 1988 Applied and Environmental Microbiology 54 (5), pp. 1268-1274  —Preceding unsigned comment added by 195.134.80.139 (talk) 15:18, 14 March 2011 (UTC)