Talk:X-linked severe combined immunodeficiency

Refs
This article could easily make C-class status with the addition of a very few inline refs. WhatamIdoing (talk) 21:18, 13 March 2009 (UTC)

added in a sentance about gene therapy being linked to leukimia a few years after treatment, but am unsure how to insert references properly so just left the link there. Philman132 (talk) 14:43, 27 April 2009 (UTC)

Before X-SCID was moved here
I just moved X-SCID and its talk page to here, and am preserving the original talk page text below. --David Iberri (talk) 23:03, 8 May 2009 (UTC)

Some text in this article was originally taken from http://ghr.nlm.nih.gov/condition=xlinkedseverecombinedimmunodeficiency (public domain)

Merged into Severe combined immunodeficiency and redirected. The description of the disease was better in the other article, and the reference to IL-2RG was so dumbed down (taken directly from the NIH website) as to be meaningless. I kept the information about inheritance patterns and created an X-linked SCID section in the other article. Thatcher131 03:21, 13 February 2006 (UTC)

Molecular Biology
Edited this section as it only talked about the IL-2 receptor and ignored the other Interleukin receptors that the common gamma chain is involved in, and help contribute to the disease.Philman132 (talk) 14:02, 20 May 2009 (UTC)

Treatment
I changed "acydovir" to "acyclovir" because I assumed it was a typo.

I changed "Although over 10 children have now been cured almost completely of X-SCID, four of the children have gone on to develop leukemia probably as a direct result of the therapy." to "In one particular trial, 10 children were treated at infancy for X-SCID. Nine of the 10 were cured of X-SCID. However, within two years of treatment, two of the children developed T-cell leukemia due to insertion of the IL2RG-containing virus near LMO2 (a known oncogene). A third child of the 10 developed leukemia within two years of that study being published, probably as a direct result of the therapy." I went ahead and referenced the scholarly article that the news article referred to. There were only 3 children who had developed cancer. I'm not sure why the previous editor wrote four.

Hopefully my English was alright throughout all of that. — Preceding unsigned comment added by Sakdsfhsl (talk • contribs) 09:36, 27 March 2012 (UTC)


 * I remember there being a British trial and a French trial which caused Leukaemia. In one trial one child developed cancer and in the other three children did, if I remember correctly. That's where the confusion probably came from. However, I don't have the references to hand at the moment to add them in. 94.12.82.85 (talk) 15:50, 16 April 2012 (UTC)

Gene therapy available?
"Gene therapy is also available to replace the mutant allele." It's been tested, but it's not exactly routine. Perhaps rewording would be a good idea? 128.243.253.101 (talk) 17:03, 29 February 2012 (UTC) There have only been a few human trials that I know of involving IL2RG insertion. The ones I've seen have had fairly high rates of leukemia (20-25%). The link below is to an article detailing the treatment of 10 infants with IL2RG insertion. http://angt.austrianova.com/angt/Brevia.pdf The link below is to an article pertaining to the development of leukemia after use of lentiretroviruses or gammaretroviruses. http://jvi.asm.org/content/83/1/283.full I added those in case someone more qualified would want to summarize some of the info within them and might be able to make a valuable contribution.

xq13.1 gene?
xq13.1 is the location of the gene. The gene itself is IL2RG. 94.14.166.194 (talk) 17:14, 9 March 2012 (UTC)

Someone has changed the name of the gene back but left the reference I added to back up my correction. I'm not going to start an 'edit war' but this is clearly wrong. For example, it's listed as IL2RG on Pubmed and in other literature. 128.243.253.102 (talk) 16:42, 13 March 2012 (UTC)

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