Talk:Xanthohumol

error in biosynthesis figure
Hi. I was looking at the entry on "Xanthohumol" (https://en.wikipedia.org/wiki/Xanthohumol) and noted that there was an error in the figure. The compound annotated as L-phenylalanine is incorrectly drawn. I cannot change it because it is a jpg. If the original chemdraw file was available I could fix it but I would need to have the original file. Otherwise I have to draw the whole figure from scratch.

Removed statement
The sourced statement quoted below was removed by someone. It is recorded here for posterity.

--IO Device (talk) 15:46, 24 September 2014 (UTC)

Wishful thinking (scant literature)
List of potentially useful references. However, Ferk 2016 appears to be the only published clinical trial related to a health function! David notMD (talk) 10:15, 23 March 2017 (UTC)

Ferk F, Mišík M, et al. Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters: Results of human intervention trials. Mol Nutr Food Res. 2016;60(4):773-786.

Liu M, Hansen PE, et al. Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). Molecules. 2015;20(1):754-779.

Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C. The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels. Front Physiol. 2015;6:140.

Chen X, Mukwaya E, Wong MS, Zhang Y. A systematic review on biological activities of prenylated flavonoids. Pharm Biol. 2014;52(5):655-60.

van Breemen RB, Yuan Y, et al. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops. Mol Nutr Food Res. 2014;58(10):1962-69.

Bolca S, Li J, et al. Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res. 2010;54(Suppl 2):S284-94.

Magalhães PJ, Carvalho DO, et al. Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer. Nat Prod Commun. 2009;4(5):591-610.

Possemiers S, Bolca S, et al. The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J Nutr. 2006;136(7):1862-7.

Legette L, Karnpracha C, et al. Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops. Mol Nutr Food Res. 2014;58(2):248-255.

Pichler C, Ferk F, et al. Xanthohumol prevents DNA damage by dietary carcinogens: results of a human intervention trial. Cancer Prev Res. 2017;10(2):153-160.

Abdi F, Mobedi H, Roozbeh N. Hops for menopausal vasomotor symptoms: mechanisms of action. J Menopausal Med. 2016;22(2):62-64.


 * Shown here among NIH-registered studies, two by Oregon State University are completed (but no published reports, possibly indicating no or low-interest results), with one ongoing Phase I study for safety in women. JF Stevens, Oregon State, (PI lead for 2 of the NIH-registered studies) has been tracking toward clinical trials since the late 1990s. --Zefr (talk) 16:20, 23 March 2017 (UTC)