Talk:Zinc deficiency

leukonychia
I've removed the paragraph below, as it's lacking a citation. The article on leukonychia which it links to appears well referenced, and states that it is not caused by any vitamin deficiency.

One easily recognized sign which may be caused by zinc deficiency is white spots, bands, or lines on fingernails (leukonychia). An occasional white spot is usually evidence that the immune system overcame a bacterial or some other systemic infection, and is a positive, not negative sign. Some women may have multiple parallel white bands or lines on the fingernails marking menstrual cycles when marginal zinc deficiency was present.

PiFanatic (talk) 01:07, 30 December 2011 (UTC)

food rich in zinc
A list with food items rich in zinc would be welcome. Presumably one of them is oyster. --Werfur (talk) 21:46, 30 January 2012 (UTC)

I replaced the old table (with dubious references to local and organic foods being higher in zinc) with data from the NIH. I was not sure about representing fractions in wiki markup, so I left them as UTF-8 chars. The table may be too long, but I was not sure how much data to include. I will leave it up to others to decide how much is appropriate. Pkrecker (talk) 18:00, 22 October 2014 (UTC)

leptin
I think leptin section should be removed, or documented appopriatly. —Preceding unsigned comment added by Inductionheating (talk • contribs) 01:02, 17 November 2008 (UTC)

REWRITE
I will rewrite this entire article for organization, clarity, and to bring it up to date.

IiKkEe (talk)
 * Please read WP:MEDMOS and WP:MEDRS. References are required. All the bolding is inappropriate. Thus reverted. Doc James  (talk · contribs · email) (if I write on your page reply on mine) 05:39, 23 August 2014 (UTC)
 * Thank you for your interest in improving this article. I am very familiar WP:MEDMOS and WP:MEDRS. As I understand WP these are guidelines, not rules or laws, and common sense can trump these guidelines on occasion. Heavy referencing of scientific articles is encouraged, not required. When a statement is made in an article that a reader feels should be referenced, that reader is to add "citation needed", notify the editor who authored the statement based on the Editing History section, and provide that person ample opportunity to reference the statement, or object on this Talk page. Only if the author fails to respond should the statement be deleted.

So you deleted everything I added to this article, with the justification that I used bolding, and I had not added references. I used no bolding, and I assure you references are forthcoming after I have reorganized and clarified, and deleted inaccurate and irrelevant information for the entire article. You might look at the articles Platelet, Ghrelin, and Leptin, all of which I completely rewrote, and also look at the discussions that were provoked on the Talk Page of those articles during the rewrite. As I understand, edit warring occurs when someone reverts something a second time after it has been restored once. I will restore what I have written section by section beginning now, and I invite you to state any objections, with reasons, here on this talk Page to anything I write so we can discuss your objections and perhaps reach some compromise, rather than deleting without discussion. Also if you believe anything I have said here is incorrect, I hope you will point it out to me.

IiKkEe (talk) 07:53, 28 August 2014 (UTC)
 * While WP:MEDMOS is a guideline making a new change against it often requires consensus. Doc James  (talk · contribs · email) (if I write on your page reply on mine) 07:55, 28 August 2014 (UTC)

I have restored some of the article to adhere to the Manual of style. The reason we use it this is so that articles can be navigated sensibly, even if you aren't the one to have written them. See the headers section of the manual of style.

Since you say the references are coming I will not delete any content - but remember if they aren't there the content may be deleted entirely - and they must adhere to what are defined as reliable sources for medical content. -- CFCF  🍌 (email) 11:31, 28 August 2014 (UTC)

I have moved your draft to Talk:Zinc deficiency/sandbox please finish adding any references and make sure it adheres to the style guide and reference guides before taking it live. -- CFCF  🍌 (email) 11:49, 28 August 2014 (UTC)
 * These changes are poor. A case report in medical hypothesis is not a suitable source and yet this one was used. Many of the other refs were primary sources when we have a lot of good secondary sources available. Doc James  (talk · contribs · email) (if I write on your page reply on mine) 12:05, 28 August 2014 (UTC)

Short section on oral manifestations of zinc deficiency has been added
...although I added this as a separate section, I feel the whole signs and symptoms section could be made more cohesive, perhaps into a long list divided according to body site. Matthew Ferguson 57 (talk) 00:27, 31 August 2014 (UTC)
 * We try to write in prose rather than in lists. Doc James  (talk · contribs · email) (if I write on your page reply on mine) 04:08, 31 August 2014 (UTC)
 * Very well, but still I feel subsections would be appropriate. Also, why is diarrhea discussed in the signs and symptoms section? Is it not a cause of zinc deficiency rather than a sign/symptom? Matthew Ferguson 57 (talk) 07:02, 31 August 2014 (UTC)


 * Zinc deficiency can be either a cause or an effect of diarrhea, or both. IiKkEe (talk) 05:02, 5 September 2014 (UTC)

Edit conflict
I was redrafting the signs and symptoms section when there has been a conflict. I will come back later. Pasted the content here for now. Matthew Ferguson 57 (talk) 07:28, 31 August 2014 (UTC)

Zinc is a cofactor for many enzymes and transcription factors. It is involved in nucleic acid (ribonucleic acid and deoxyribonucleic acid), protein, lipid and carbohydrate metabolism. Severe zinc deficiency therefore causes disruption to many different metabolic pathways and tissues, causing impaired growth and development, and disruption of reproduction and immune function.

Skin, nails and hair
Zinc deficiency may manifest as acne, eczema, xerosis (dry, scaling skin), seborrheic dermatitis, or alopecia (thin and sparse hair.

Mouth
In the mouth, zinc deficiency can manifest as non-specific oral ulceration and stomatitis, and there may be white tongue coating. Rarely it can cause angular cheilitis (sores at the corners of the mouth). Zinc deficiency may also contribute to hypogeusia (decreased ability to taste) or dysgeusia (taste disturbance),     and possibly burning mouth syndrome.

Eyes
Night blindness may be a feature of severe zinc deficiency. However, most reports of night blindness and abnormal dark adaptation in humans with zinc deficiency have occurred in combination with other nutritional deficiencies (e.g. vitamin A).

Growth and development
Zinc deficiency in children can cause delayed growth and delayed puberty.

Immune system
Impaired immune function in children with zinc deficiency can lead to the development of conditions such as pneumonia.

Useful source
User:idknow
 * http://www.who.int/publications/cra/chapters/volume1/0257-0280.pdf — Preceding unsigned comment added Matthew Ferguson 57 (talk • contribs) 08:06, 31 August 2014 (UTC)
 * I'm a totally disgusted with the use of the word "human"; I am not human and I am not an animal. I am Man!  That is my family-name!!

Split article up?
Should the article be split into 3: humans/animals, plants and soil?

They seem too different topics to me... Matthew Ferguson 57 (talk) 20:52, 1 September 2014 (UTC)
 * My vote would be to not split since the major cause of human deficiency is soil/plant deficiency. It would be difficult to discuss the one without involving the others.IiKkEe (talk) 14:13, 4 September 2014 (UTC)
 * Per WP:MEDMOS we have human info first. Than at the end we have a section "other animals" "plants" etc. If these section get to large they can than be split off as subpages. Doc James  (talk · contribs · email) (if I write on your page reply on mine) 14:48, 4 September 2014 (UTC)
 * Is there any way to make it more clear which parts of the article refer to humans, and which to animals, plants and soils? Matthew Ferguson (talk) 11:19, 7 September 2014 (UTC)

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Dietary deficiency
The sub-section on Dietary deficiency says: "n the U.S., the Recommended Dietary Allowance (RDA) is 8 mg/day for women and 11 mg/day for men." But the table that follows uses 15 mg/day as it's "Percentage of recommended daily intake" comparison. Pick one. -- PaulxSA (talk) 11:21, 4 October 2018 (UTC)
 * Percent Daily Values, used on labels to convey percent of daily intake per serving, updated to 11 mg. So now in accord with RDA. See the Zinc article for more details. David notMD (talk) 21:29, 21 January 2019 (UTC)

Quality of references
Some of the references are to individual clinical trials, hence not to MEDRS. A conservative approach will be to search for higher quality references as replacements rather than wholesale deletion of content. David notMD (talk) 15:29, 1 February 2019 (UTC)

Contradiction; can the body store zinc, or not?
The article states, without any source: "As biosystems are unable to store zinc"

The article also states, with a source: "History In 1929 Lutz measured zinc in numerous human tissues using the dithizone technique and estimated total body zinc in a 70 kg man to be 2.2 grams."

Given the average intake of zinc from 8-10mg, the 2200mg would represent a store of zinc of how many days? 2200mg/10mg = 220 days. Is that a store of zinc, or not? It appears obvious that it is. Would someone else please follow up and make the appropriate correction, if needed?

BMS
Hello David - your reasoning for the removal of the material is not clear - the reference is used on the page Burning mouth syndrome - again states clearly it is a rare cause and since so little is really known about this debilitating condition can see no reason for not including it.--Iztwoz (talk) 15:38, 1 February 2019 (UTC)

Possible copyright problem
This article has been revised as part of a large-scale clean-up project of multiple article copyright infringement. (See the investigation subpage) Earlier text must not be restored, unless it can be verified to be free of infringement. For legal reasons, Wikipedia cannot accept copyrighted text or images borrowed from other web sites or printed material; such additions must be deleted. Contributors may use sources as a source of information, but not as a source of sentences or phrases. Accordingly, the material may be rewritten, but only if it does not infringe on the copyright of the original or plagiarize from that source. Please see our guideline on non-free text for how to properly implement limited quotations of copyrighted text. Wikipedia takes copyright violations very seriously. Moneytrees🌴Talk🌲Help out at CCI! 01:21, 25 May 2020 (UTC)

"hyperzincuria"
This term is missing from Wikipedia altogether. Wiktionary has a definition : https://en.wiktionary.org/wiki/hyperzincuria. &mdash;Jerome Potts (talk) 17:12, 6 August 2020 (UTC)