Talk:Zonisamide

I am not quite sure not being a pharmacist myself, but the following sentence seems to contain an error:"...increasing the levels of the glutamate transport protein in the brain while decreasing the amount of GABA transport protein, in other words, inhibiting the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate."

AEDs usually enhance GABA activiy or release and inhibit Glutamate (not the other way round) in order to depotentiate the neuron and thus preventing or lowering voltage below the seizure threshold.

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I'm pretty sure some doctors are also experimenting with using this as a migraine preventative, as with many other anticonvulsants. Blahity 04:13, 26 October 2006 (UTC) My clever reasoning above is that I'm on it for that. My neurologist supposedly specializes in headaches (Dr. Schulman at Lankenau Hospital near Philadelphia) and he's trying it in a manner similar to the use of Topamax for the purpose. It's a fairly new medication and I don't know if theres any literature on the subject of the use, just thought I'd write it here, and clarify my reasoning. 71.224.32.208 07:12, 17 November 2006 (UTC)

I had this drug in my system along with 2.5mg coumadin and 200 mg. celebrex to offset my antiphospholipid syndrom. My blood became anemic almost overnight, I started to notice my hearing becoming incredibly sharper than it had ever been-too sharp in fact! I have had to go back to my lab for blood tests weekly due to the fact that this drug messed up my system so much. Then the halucinations started. I called my neurologist as soon as it became clear to myself and the people who care about me that my proublems all seemed to start as soon as I began taking this drug. It changed the way I percieved sounds as well as sights. I've never been so afraid before. Thank God I have people that care enough to tell me I was becomming illogical. The episodes became overwhelming. I've been off zonisamide for four days now and I feel like a new woman. Please be aware of this potential side effect! I had the horror of hallucinations, both visual and audial. This drug harmed me as I never expected. —Preceding unsigned comment added by 72.92.228.229 (talk) 20:26, August 30, 2007 (UTC)

Advise the FDA for adverse drug reactions
This reply is to the previous comment about adverse reactions to medication. Please see http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053074.htm and consult with your doctor. Best regards. I am reviewing this medication for off label treatment of stiff person syndrome. See also http://synapticmhz.blogspot.com/2015/03/sps-awareness-day-3-18-2015.html 75.142.138.213 (talk) 08:55, 14 March 2015 (UTC)