Template talk:Relative affinities of levonorgestrel and metabolites

Affinity baselines (100%)
The "baseline" affinities to which the affinities of levonorgestrel and its metabolites are being compared too seem a bit strange for me. Usually the "baseline/100%" affinity is that of an endogenous hormone, such as progesterone at the PR and testosterone at the AR. This template uses metribolone at the AR and promegastone at the PR. The main concern I have is that this makes it confusing, since the templates can't be directly compared (since they are all relative to a different baseline) and since the endogenous hormones are what are generally used, users will have to compare the relative affinity in the template to the relative affinity of the baseline to the endogenous drug; for example levonorgestrel has 45% androgen receptor affinity with metribolone being the 100% baseline, which in turn has a 204% affinity to the AR compared to testosterone according to its own Wikipedia article. This would give levonorgestrel a 91.8% relative affinity compared to testosterone, which is what AR affinity is generally compared to.

I understand this is because the source data uses those chemicals as the baseline. Would it be possible to change this template and have the baselines be set as the endogenous hormones by doing the calculations ourselves? I think this would make it less confusing for the average reader.

Maddtroller (talk) 19:10, 4 May 2021 (UTC)